Every Other Day Aspirin Reduces Colorectal Cancer Risk
July 21, 2013 by Robert Wascher
Filed under A Cancer Prevention Guide for the Human Race, Breast Cancer, Cancer, Cancer Prevention, Colon Cancer Risk, Colorectal Cancer, Colorectal Cancer Risk, NSAIDs, Weekly Health Update, aspirin, breast cancer prevention, breast cancer risk, cancer risk, colon cancer, colorectal cancer prevention, health, prevention, rectal cancer
A large new prospective study finds that every-other-day low-dose aspirin significantly reduces colorectal cancer risk.
EVERY OTHER DAY ASPIRIN REDUCES COLORECTAL CANCER RISK
As I discuss in my bestselling book, A Cancer Prevention Guide for the Human Race, aspirin has been shown, by numerous studies, to reduce the risk of colorectal cancer. However, daily aspirin use is not without its risks, including GI tract ulceration and bleeding. Now, a newly published study suggests that low-dose aspirin, when taken every other day, may still significantly reduce colorectal cancer risk. This new study appears in the current issue of the Annals of Internal Medicine.
This study is part of the prospective Women’s Health Study, and included 33,682 adult female health professionals who volunteered to participate in this large and ongoing prospective randomized clinical trial. Study participants were secretly randomized to receive either 100 mg of aspirin every other day or an identical-appearing placebo pill in this double-blinded placebo-controlled trial. Follow-up in this very large prospective study averaged nearly 10 years.
During the decade-long course of this clinical study, 5,071 participants were diagnosed with cancer, and 1,391 of the study volunteers died of cancer.
The use of every-other-day aspirin had no apparent impact on the risk of cancers of the breast or lung. However, every-other-day low-dose aspirin use was associated with a rather dramatic 42 percent reduction in colorectal cancer risk among the women who were followed for the longest duration in this study.
This high-powered prospective, randomized, blinded, placebo-controlled clinical trial adds to an already large body of evidence showing that the daily use of low-dose aspirin can significantly reduce colorectal cancer use. In the case of this study, however, taking low-dose aspirin every other day still yielded a very impressive reduction in colorectal cancer risk. At the same time, even every-other-day dosing of aspirin was still associated with a measurable increase in the risk of aspirin’s known side effects, including a 14 percent increase in the risk of GI tract bleeding and a 17 percent increase in the risk of GI tract ulcers.
The findings of this important prospective, randomized, controlled clinical trial suggest that low-dose aspirin does not have to be taken every single day to provide significant colorectal prevention benefits. However, in view of the aspirin-associated GI tract side effects noted in this study, even with every-other-day use, it is important that you consult your personal physician before you start taking aspirin.
For more information on this and other evidence-based approaches to cancer prevention, obtain your copy of A Cancer Prevention Guide for the Human Race.
For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my bestselling book, “A Cancer Prevention Guide for the Human Race,” from Amazon, Barnes & Noble, Books-A-Million, Vroman’s Bookstore, and other fine bookstores!
Within one week of publication, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books. Within three months of publication, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.com “Top 100 New Book Releases in Cancer” list.
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Disclaimer: As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity
Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author
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