Colonoscopy Prevents Colorectal Cancer



A large new public health study shows that colonoscopy remains the single most effective tool for the prevention of colorectal cancer.


 

COLONOSCOPY PREVENTS COLORECTAL CANCER

As I discuss in my book, A Cancer Prevention Guide for the Human Race, colorectal cancer remains the third most common type of cancer in both men and women, and the third most common cause of cancer death among both men and women.

In A Cancer Prevention Guide for the Human Race, I discuss the known lifestyle and dietary factors associated with colorectal cancer risk, as well as evidence-based strategies to reduce your risk of developing this form of cancer.  One of the most important of these colorectal prevention strategies is screening colonoscopy.  Since the vast majority of colon and rectal cancers first begin as benign polyps, the identification and removal of these premalignant polyps (“adenomas”) can actually prevent the future development of this potentially deadly form of cancer.

Now, a new clinical research study, which appears in the current issue of the New England Journal of Medicine, reveals just how important, and how effective, screening colonoscopy is in preventing colon and rectal cancer.

The Nurses’ Health Study and the Health Professionals Follow-up Study are two very large ongoing prospective public health studies.  In this case, 88,902 volunteers from these two studies were followed for an average of 22 years.  During this time, 1,815 study volunteers were diagnosed with colorectal cancer and 474 volunteers died of colorectal cancer.

Among the volunteers who underwent screening colonoscopy, there was a 43 percent reduction in the risk of developing colorectal cancer if they had undergone polyp removal during colonoscopy, compared to study volunteers who did not undergo colonoscopy.  Among the study participants who underwent colonoscopy, and who had no polyps detected, their risk of developing colorectal cancer was 56 percent lower when compared to the volunteers who did not undergo colonoscopy.  The authors of this study also noted that screening colonoscopy was associated with a 68 percent reduction in the risk of dying from colorectal cancer, based upon the results of this very large prospective public health study.

The findings of this very important public health study show that screening colonoscopy remains the single most effective method of preventing colorectal cancer, and preventing death due to colorectal cancer.  At the present time, the American Cancer Society recommends that people with an average risk of developing colorectal cancer should undergo their first colonoscopy at age 50.  If this initial screening colonoscopy is normal, then patients should undergo routine screening colonoscopy every 10 years thereafter, as long as each subsequent colonoscopy remains normal.

Although many people shy away from colonoscopy due to concerns about discomfort, or due to modesty concerns, colonoscopy remains one of the most effective cancer screening and cancer prevention tools available.  Therefore, if you are due (or overdue) for screening colonoscopy, please do not delay in having this potentially lifesaving test performed.


For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my bestselling book, “A Cancer Prevention Guide for the Human Race,” from AmazonBarnes & NobleBooks-A-MillionVroman’s Bookstore, and other fine bookstores!

Within one week of publication, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books. Within three months of publication, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.com Top 100 New Book Releases in Cancer” list.


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CNN Story on CTCA’s Organic Farm in the Phoenix Area

Dr. Wascher Discusses Signs & Symptoms of Skin Cancer

Profile of Dr. Wascher by Oncology Times

Bio of Dr. Wascher at Cancer Treatment Centers of America

Dr. Wascher Discusses Predictions of Decreased Cancer Risk on azfamily.com

Dr. Wascher Discusses Environmental Risk Factors for Breast Cancer on Sharecare

Dr. Wascher Answers Questions About Cancer on talkabouthealth.com

Dr. Wascher Discusses Cancer Prevention Strategies on LIVESTRONG

Dr. Wascher Discusses Cancer Prevention on Newsmax

Dr. Wascher Answers Questions About Cancer Risk & Cancer Prevention on The Doctors Radio Show

Dr. Wascher Discusses Lymphedema After Breast Surgery on cancerlynx.com

Dr. Wascher Discusses Hormone Replacement Therapy & Breast Cancer Risk on cancerlynx.com

Dr. Wascher Discusses Chronic Pain After Mastectomy for Breast Cancer on cancerlynx.com

Dr. Wascher Discusses Sentinel Lymph Node Biopsy for Cancer on cancersupportivecare.com

Dr. Wascher Discusses the Role of Exercise in Cancer Prevention on Open Salon

Dr. Wascher Discusses Aspirin as a Potential Preventive Agent for Pancreatic Cancer on eHealth Forum

Dr. Wascher Discusses Obesity & Cancer Risk on eHealth Forum

Dr. Wascher Discusses the Role of Radiation Therapy in the Treatment of Breast Cancer on Sharecare

Dr. Wascher Discusses the Treatment of Stomach Cancer on Sharecare

Dr. Wascher Discusses the Management of Metastatic Cancer of the Liver on Sharecare

Dr. Wascher Discusses Obesity & Cancer Risk on hopenavigators.com

Dr. Wascher Discusses Hormone Replacement Therapy & Breast Cancer Risk on interactmd.com

Dr. Wascher Discusses Thyroid Cancer on health2fit.com

 

 

Links to Other Breaking Health News

Parasite in Cat Feces May Affect Brain Function

Lung Diseases Cause 1 in 10 Deaths

Music May Heal The Heart

Poor Oral Hygiene Increases Cancer Risk

Autism May Affect Female Brains Differently than Male Brains

Child Obesity Rates Fall for the First Time

New Teeth Grown from Urine

HPV Virus Newly Linked to One-Third of All Oral Cancer Cases

FDA Approves New Brain Scan to Assess for ADHD in Kids

Epidemic of Drug Overdose Deaths Among Middle-Aged Women

Man Loses 155 Pounds

Naked Mole Rat May Provide Important Cancer Prevention Clue

The Effects of Poverty on the Brain

Half of Us Will Develop Cancer in Our Lifetimes

Protein Critical for Long-Term Memory Identified

HPV Virus and Cancer Risk

Probiotics May Decrease Antibiotic-Associated Diarrhea caused by C. difficile

3-D Printer Helps to Save Baby’s Life

Experimental Drug May Reduce Heart Damage after Heart Attack

Vitamin D May Improve Asthma Symptoms

Doctor Provides Patients with Own Feces for Fecal Transplants

Rising Arsenic Levels in Chicken

Dramatic Increase in Suicide Rate Among Middle Aged Americans Over the Past Decade

Cutting Umbilical Cord Too Soon May Cause Anemia in Newborns

Spiny New Bandage May Speed Healing of Skin Wounds

Study Confirms that Men Really Do Have Trouble Reading the Thoughts of Women

Deadly new Bird Flu Strain Cases Continue to Rise

Abdominal Fat Increases Kidney Disease Risk

Increasing Dietary Potassium & Decreasing Salt Intake Reduces Stroke Risk

A New Explanation for the Link Between Red Meat & Cardiovascular Disease

Deadly New Bird Flu Identified in China

Infection Risk: Keeping an Eye on Your Dentist

Couple Loses 500 Pounds in Two Years

Coffee May Reduce Crash Risk for Long-Distance Drivers

Tiny Implant Tells Your Smart Phone When You Are Having A Heart Attack

Transplanted Kidney Causes Death Due to Rabies

Eating While Distracted Increases Calorie Intake

Resistant Bacteria are on the Rise

High Levels of Stress Linked to an Increase in Heart Disease Risk

Small Snacks Cut Hunger as Well as Big Snacks

Poor Sleep May Increase the Risk of Heart Failure

Ancient Mummies Found to Have Heart Disease by CT Scan

Physically Fit Kids Do Better on Math & Reading Tests

How Melanoma Skin Cancer Evades the Immune System

Possible Link Between BPA and Asthma

Baby Boomers Appear Less Healthy Than Their Parents

The Biology of Love in the Brain

Millennials May be the Most Stressed-Out Generation

Even Modest Alcohol Intake Raises Cancer Risk

Why Do Boys Receive Lower Grades than Girls?

Negative Emotions and Feelings Can Damage Your Health

Canker Sore Drug Cures Obesity (At Least in Mice…)

How Technology is Changing the Practice of Medicine

New Salt Intake Guidelines for Children

High Levels of Distress in Childhood May Increase Risk of Heart Disease in Adulthood

Quitting Tobacco by Age 40 Restores a Normal Lifespan in Smokers

Cancer Death Rates Continue to Fall

Self-Help Books Improve Depression

Marines Try Mindfulness and Meditation to Reduce PTSD

Dying Nurse Volunteers Herself to Teach Nursing Students about the Dying

Regular Walks Cut Stroke Risk

Falling Asleep While Driving More Common than Previously Thought

Celebrity Health Fads Debunked

Obesity Among Young Children May Be Declining

Fresh Fruits & Vegetables May Reduce Breast Cancer Risk

Satisfaction with Life May Actually Increase with Age

Brain Changes in the Elderly May Increase Susceptibility to Being Scammed


Dr. Wascher’s Home Page



According to recent Bureau of Labor Statistics, the unemployment rate for veterans who served on active duty between September 2001 and December 2011 is more than 12 percent.  A new website, Veterans in Healthcare, seeks to connect veterans with potential employers.  If you are a veteran who works in the healthcare field, or if you are an employer who is looking for physicians, advanced practice professionals, nurses, corpsmen/medics, or other healthcare professionals, then please take a look at Veterans in Healthcare. As a retired veteran of the U.S. Army, I would also like to personally urge you to hire a veteran whenever possible.


Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


 

I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people from around the world who visit this premier global health information website every month.  Over the past 12 months, more than 3.5 million pages of high-quality medical research findings were served to the worldwide audience of health-conscious readers.  As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.


 


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Women in their 40s May Benefit from Annual Mammograms



A new study finds that women in their 40s with dense breasts benefit from annual mammograms.


 

WOMEN IN THEIR 40s MAY BENEFIT FROM ANNUAL MAMMOGRAMS

The U.S. Preventive Services Task Force (USPSTF) ignited a firestorm of controversy in 2009 when the government agency recommended that most women between the ages of 50 and 74 should undergo screening mammograms every other year,instead of every year. Even more controversial was the USPSTF’s recommendation that most healthy women between the ages and 40 and 49 should no longer undergo routine screening mammograms. Numerous cancer advocacy groups, including the American Cancer Society, subsequently recommended that the USPSTF’s revised guidelines for screening mammograms should, essentially, be ignored, and that women with an average risk of developing breast cancer should continue to undergo annual screening mammograms starting at age 40.

In 2010, following the USPSTF’s controversial recommendations, a significant drop in the number of annual screening mammograms performed on women in their 40s was observed, leading to concern among some breast cancer experts that many cases of breast cancer might go undiagnosed among 40 to 49 year-old women.

Now, a newly published study, which appears in the online edition of JAMA Internal Medicine, provides important new data regarding the potential impact of switching from annual screening mammograms to every-other-year (biennial) mammograms.

In this very large study, researchers analyzed prospectively collected data from mammography facilities throughout the United States that participated in the Breast Cancer Surveillance Consortium. Data was prospectively collected on 11,474 women who had been diagnosed with breast cancer and 922,624 women without breast cancer.

The findings of this enormous public health study strongly suggest that the USPSTF’s recommendations that women between the ages of 50 and 74 undergo every-other-year mammograms may actually be reasonable and safe. When compared to women in this age range who underwent screening mammograms every year, the women who underwent biennial mammograms did not have a higher incidence of advanced-stage breast cancers. An additional important finding was that even women aged 50 or older with very dense breast tissue, or women above 50 who had taken hormone replacement therapy, appeared not to experience any harm by undergoing biennial mammograms instead of annual mammograms. As both of these factors increase a woman’s lifetime risk of developing breast cancer, the finding of this study that women between 50 and 74 years of age can safely undergo screening mammograms every other year (instead of every year) is of particular significance.

In contrast to women between the ages of 50 and 74, this research study’s findings regarding women between the ages of 40 and 49 call into question the USPSTF’s recommendation that women in this age range need not undergo regular screening mammograms. Among the women in this study between the ages of 40 and 49, every-other-year screening mammograms (rather than every year) resulted in a significant increase in the incidence of more advanced-stage breast cancers. In fact, women in this age range, who often have very dense breast tissue, were 89 percent more likely to be diagnosed with advanced-stage breast cancers if they underwent every-other-year mammograms when compared to comparably aged women with dense breast tissue who underwent annual screening mammograms.

I consider this to be a very important clinical research study, and its findings may well lead to changes in the current recommendations regarding screening mammograms. At the same time, it will be important to follow the nearly one million women who participated in this public health study, to see if breast long-term cancer survival rates are impacted by the timing of screening mammograms (i.e., annual versus biennial mammograms).

It is critically important to avoid the multiple lifestyle and dietary factors known to increase the risk of breast cancer. For more research-based information on this important topic, please read the extended chapter on breast cancer in my bestselling book, A Cancer Prevention Guide for the Human Race.

 

For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my bestselling book, “A Cancer Prevention Guide for the Human Race,” from AmazonBarnes & Noble, Books-A-Million, Vroman’s Bookstore, and other fine bookstores!


Within one week of publication, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books. Within three months of publication, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.com Top 100 New Book Releases in Cancer” list.


Join Dr. Wascher on Facebook


Additional Links for Robert A. Wascher, MD, FACS

Profile of Dr. Wascher by Oncology Times

Bio of Dr. Wascher at Cancer Treatment Centers of America

Dr. Wascher Discusses Predictions of Decreased Cancer Risk on azfamily.com

Dr. Wascher Discusses Environmental Risk Factors for Breast Cancer on Sharecare

Dr. Wascher Answers Questions About Cancer on talkabouthealth.com

Dr. Wascher Discusses Cancer Prevention Strategies on LIVESTRONG

Dr. Wascher Discusses Cancer Prevention on Newsmax

Dr. Wascher Answers Questions About Cancer Risk & Cancer Prevention on The Doctors Radio Show

Dr. Wascher Discusses Lymphedema After Breast Surgery on cancerlynx.com

Dr. Wascher Discusses Hormone Replacement Therapy & Breast Cancer Risk on cancerlynx.com

Dr. Wascher Discusses Chronic Pain After Mastectomy for Breast Cancer on cancerlynx.com

Dr. Wascher Discusses Sentinel Lymph Node Biopsy for Cancer on cancersupportivecare.com

Dr. Wascher Discusses the Role of Exercise in Cancer Prevention on Open Salon

Dr. Wascher Discusses Aspirin as a Potential Preventive Agent for Pancreatic Cancer on eHealth Forum

Dr. Wascher Discusses Obesity & Cancer Risk on eHealth Forum

Dr. Wascher Discusses the Role of Radiation Therapy in the Treatment of Breast Cancer on Sharecare

Dr. Wascher Discusses the Treatment of Stomach Cancer on Sharecare

Dr. Wascher Discusses the Management of Metastatic Cancer of the Liver on Sharecare

Dr. Wascher Discusses Obesity & Cancer Risk on hopenavigators.com

Dr. Wascher Discusses Hormone Replacement Therapy & Breast Cancer Risk on interactmd.com

Dr. Wascher Discusses Thyroid Cancer on health2fit.com

 

Links to Other Breaking Health News

Vitamin D May Improve Asthma Symptoms

Doctor Provides Patients with Own Feces for Fecal Transplants

Rising Arsenic Levels in Chicken

Dramatic Increase in Suicide Rate Among Middle Aged Americans Over the Past Decade

Woman with Transplanted Uterus Becomes Pregnant

Cutting Umbilical Cord Too Soon May Cause Anemia in Newborns

Recent Advances in Prosthetic Limbs to Help Boston Marathon Bombing Victims

Spiny New Bandage May Speed Healing of Skin Wounds

Study Confirms that Men Really Do Have Trouble Reading the Thoughts of Women

Deadly new Bird Flu Strain Cases Continue to Rise

Abdominal Fat Increases Kidney Disease Risk

Increasing Dietary Potassium & Decreasing Salt Intake Reduces Stroke Risk

A New Explanation for the Link Between Red Meat & Cardiovascular Disease

Deadly New Bird Flu Identified in China

Infection Risk: Keeping an Eye on Your Dentist

Couple Loses 500 Pounds in Two Years

Coffee May Reduce Crash Risk for Long-Distance Drivers

Tiny Implant Tells Your Smart Phone When You Are Having A Heart Attack

Transplanted Kidney Causes Death Due to Rabies

Eating While Distracted Increases Calorie Intake

Resistant Bacteria are on the Rise

High Levels of Stress Linked to an Increase in Heart Disease Risk

Small Snacks Cut Hunger as Well as Big Snacks

Poor Sleep May Increase the Risk of Heart Failure

Ancient Mummies Found to Have Heart Disease by CT Scan

Physically Fit Kids Do Better on Math & Reading Tests

How Melanoma Skin Cancer Evades the Immune System

Possible Link Between BPA and Asthma

Baby Boomers Appear Less Healthy Than Their Parents

The Biology of Love in the Brain

Millennials May be the Most Stressed-Out Generation

Even Modest Alcohol Intake Raises Cancer Risk

Why Do Boys Receive Lower Grades than Girls?

Negative Emotions and Feelings Can Damage Your Health

Canker Sore Drug Cures Obesity (At Least in Mice…)

How Technology is Changing the Practice of Medicine

New Salt Intake Guidelines for Children

High Levels of Distress in Childhood May Increase Risk of Heart Disease in Adulthood

Quitting Tobacco by Age 40 Restores a Normal Lifespan in Smokers

Cancer Death Rates Continue to Fall

Self-Help Books Improve Depression

Marines Try Mindfulness and Meditation to Reduce PTSD

Dying Nurse Volunteers Herself to Teach Nursing Students about the Dying

Regular Walks Cut Stroke Risk

Falling Asleep While Driving More Common than Previously Thought

Celebrity Health Fads Debunked

Obesity Among Young Children May Be Declining

Fresh Fruits & Vegetables May Reduce Breast Cancer Risk

Satisfaction with Life May Actually Increase with Age

Brain Changes in the Elderly May Increase Susceptibility to Being Scammed

 



Dr. Wascher’s Home Page



According to recent Bureau of Labor Statistics, the unemployment rate for veterans who served on active duty between September 2001 and December 2011 is more than 12 percent.  A new website, Veterans in Healthcare, seeks to connect veterans with potential employers.  If you are a veteran who works in the healthcare field, or if you are an employer who is looking for physicians, advanced practice professionals, nurses, corpsmen/medics, or other healthcare professionals, then please take a look at Veterans in Healthcare. As a retired veteran of the U.S. Army, I would also like to personally urge you to hire a veteran whenever possible.


Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


 

I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people from around the world who visit this premier global health information website every month.  Over the past 12 months, more than 3.1 million pages of high-quality medical research findings were served to the worldwide audience of health-conscious readers.  As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.


 


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Addition of MRI to Mammogram and Ultrasound Increases Breast Cancer Detection






 

New research shows that adding MRI to mammogram and ultrasound increases breast cancer detection rate, but with a high rate of false positive results.


 

 

ADDITION OF MRI TO MAMMOGRAM AND ULTRASOUND INCREASES BREAST CANCER DETECTION

Currently, women who are at an average risk of developing breast cancer are advised to undergo annual screening mammograms beginning at 40 to 45 years of age.  Mammography, like any medical test, is not perfect (at least 10 to 20 percent of breast cancers will not show up on a mammogram among women who are at average risk for this type of cancer).  Moreover, mammography, which relies upon low-powered x-rays to form images of the breasts, is especially challenged by women with dense breast tissue, which is, by itself, a known risk factor for breast cancer.

In many cases, the addition of ultrasound to mammography can help to form more accurate images of dense breast tissue, and is also useful for further evaluation of indeterminate breast abnormalities identified by mammography.  (Also, both the lobular sub-type of breast cancer and small “low-grade” breast cancers tend to show up better on ultrasound than they do on mammograms.)  Together, the combination of mammography and ultrasound can accurately detect approximately 85 to 90 percent of breast cancers in women with normal-density breast tissue; but, once again, in women with dense breast tissue (including most women under the age of 40), the sensitivity and overall accuracy of mammography plus ultrasound is often considerably decreased.

Magnetic resonance imaging, or MRI, has become a popular tool for breast imaging, although, like mammography and ultrasound, MRI of the breast has its downsides as well.  MRI is known to be much more sensitive than either mammography or ultrasound in identifying breast cancers, with most studies showing a 95 percent or greater sensitivity associated with MRI.  However, this exquisite sensitivity of breast MRI, as I discuss in my bestselling book, A Cancer Prevention Guide for the Human Race, is also associated with poor specificity (i.e., a high false-positive rate).  Because of its poor specificity, MRI scans of the breast will be wrong, or falsely-positive, in 15 to 35 percent of cases where an abnormality is detected.  Although there are other reasons as well, this high false-positive rate is the primary reason that MRI scans are not routinely used to screen for breast cancer.

As I have noted, none of these three common breast cancer screening tests are perfect, and each of them will miss some cancers that the other types of scans might pick up. With this information in mind, a newly published study, which appears in the current issue of the Journal of the American Medical Association, examines the potential role of ultrasound and MRI scans as supplements to screening mammograms in women who are at an increased risk for developing breast cancer.

In this prospective clinical research study, 612 women deemed to be at increased risk for breast cancer underwent three years of annual breast cancer screening exams with mammography and ultrasound.  After completing these three years of annual screening with mammography and ultrasound, these women additionally underwent MRI scans of their breasts.  Abnormalities suspicious for cancer, based upon any of these three diagnostic tests, were further evaluated by biopsy.  This cohort of women volunteers was then followed for an additional 12 months, to monitor them for any signs of interval development of breast cancer.

The 612 women who underwent mammography, ultrasound and MRI screening were also part of a larger group of 2,662 high-risk women (54 percent of whom had a personal history of a prior breast cancer) who enrolled in this study, and who underwent annual breast cancer screening with both mammography and ultrasound.  Altogether, 110 of these 2,662 women were diagnosed with a new breast cancer during the course of this prospective clinical research study.

The results of this study clearly illustrate the limitations of currently available breast cancer screening tests, particularly among high-risk women.  Following three years of annual screening, only 52 percent of the breast cancers that arose were detected by mammography alone in these high-risk women, although the false-positive rate of mammography was very low, at 9 percent.  The addition of ultrasound to mammography improved the sensitivity, or detection rate, to 76 percent, with a false-positive rate of 16 percent.  When MRI was added to mammography and ultrasound, the detection rate (sensitivity) for breast cancer improved, significantly, to 100 percent, although the false-positive rate increased greatly due to the poor specificity of MRI and, to a lesser extent, ultrasound.  When these three breast imaging modalities were combined, 35 percent of the abnormalities identified turned out to be benign lesions, and not cancer, following biopsy or other confirmatory diagnostic procedures.

This study confirms that essentially 100 percent of detectable breast cancers can be identified using a combination of mammography, ultrasound and MRI.  However, this high level of sensitivity comes at a significant cost in that more than one-third of the abnormalities identified by the combined use of these three breast imaging modalities will, upon further testing, including biopsy, turn out to be completely benign.  Therefore, this high false-positive rate, particularly associated with breast MRI, is the Achilles heel of this combined imaging approach to breast cancer screening.

Fortunately, there are emerging new breast imaging technologies that appear to have the same very high sensitivity rate as MRI, while maintaining the high specificity (i.e., low false-positive) rate of mammography.  Among these promising technologies are Breast-Specific Gamma Imaging and Positron Emission (PET) Mammography (also known as “PEM”).  Ultimately, these newer technologies, as well as even newer technologies, will most likely someday replace the use MRI to screen for breast cancer.



For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my bestselling book, “A Cancer Prevention Guide for the Human Race,” from AmazonBarnes & NobleBooks-A-MillionVroman’s Bookstore, and other fine bookstores!

Within one week of publication, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books. Within three months of publication, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list.



Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people from around the world who visit this premier global health information website every month.  (More than 1.3 million pages of high-quality medical research findings were served to the worldwide audience of health-conscious people who visited Weekly Health Update in 2011!)  As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.


 






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Breast Cancer Cells in the Blood Predict High Risk of Recurrence

Welcome to Weekly Health Update


“A critical weekly review of important new research findings for health-conscious readers”



 

BREAST CANCER CELLS IN THE BLOOD PREDICT HIGH RISK OF RECURRENCE

During my time in the lab, as a research fellow at the John Wayne Cancer Institute, I completed several research studies that revealed a powerful link between the presence of tiny numbers of cancer cells floating in the blood and overall survival in patients without any evidence of recurrent cancer by standard laboratory and radiographic tests.  In these research studies, we used a powerful test, reverse transcriptase-polymerase chain reaction (RT-PCR) to detect fragments of genetic material from otherwise undetectable cancer cells in the blood of patients with a prior history of cancer.  (RT-PCR, which can detect the presence of a single tumor cell floating amongst more than a million normal blood cells, is a powerful tool for detecting trace numbers of cancer cells present in the blood, bone marrow, lymph nodes, and other tissues of the body.)

A newly published RT-PCR research study appears in the current issue of the British Journal of Cancer. In this study, the blood of 82 early-stage breast cancer patients was tested for occult breast cancer cells using RT-PCR. Additionally, 16 patients with advanced breast cancer and 45 patient volunteers without breast cancer were used as “control groups.” All of these patient volunteers were then followed for an average of 51 months.

Among the women with very early breast cancer, 20 percent were found to have occult breast cancer cells lurking in their blood. By comparison, 81 percent of the women with late-stage breast cancer were found to have breast cancer cells circulating in their blood. (None of the healthy volunteers were found to have genetic evidence of circulating breast cancer cells in their blood.)

In this study, as with the findings of my own research in this area, the presence of rare circulating cancer cells in the blood of even patients with early-stage breast cancer was a powerful predictor of future breast cancer recurrence. Among these early-stage breast cancer patients, a positive RT-PCR test of the blood was associated with more than 5 times the risk of breast cancer recurrence (a more than 500 percent increase in recurrence risk) when compared to the early-stage breast cancer patients who did not have any detectable tumor cells circulating in their blood.

As with my own research, and the research of other cancer scientists, this newly published breast cancer research study confirms that the presence of trace numbers of cancer cells in the blood, even in patients with very early breast cancer, is highly predictive of future breast cancer recurrence. This is an important finding, and for several reasons. First of all, the detection of even tiny numbers of circulating tumor cells in the blood of early-stage breast cancer patients indicates a much worse prognosis for such patients, even when all of our standard laboratory and x-ray tests do not reveal any evidence of persistent or recurrent cancer in these same patients. Secondly, “ultra-staging” cancer patients with RT-PCR may be able to help us to identify early-stage cancer patients who might benefit from more aggressive treatment than patients who have no detectable tumor cells circulating in their blood.

Based upon the findings of this study, and those of other similar research studies (including my own), RT-PCR has the potential to become a very powerful clinical tool to help us to more accurately stage patients with early-stage cancers, and to individualize and personalize cancer treatment based upon this so-called “molecular” approach to cancer diagnosis and treatment.




For a comprehensive guide to living an evidence-based cancer prevention lifestyle, order your copy of my new book, A Cancer Prevention Guide for the Human Race.  For the price of a cheeseburger, fries, and a shake, you can purchase this landmark new book, in both paperback and e-book formats, and begin living an evidence-based cancer prevention lifestyle today!

For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, A Cancer Prevention Guide for the Human Race,” from Amazon, Barnes & Noble, Books-A-Million,Vroman’s Bookstore, and other fine bookstores!

On Thanksgiving Day, 2010, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books! On Christmas Day, 2010, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list!


Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity



Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author



For a different perspective on Dr. Wascher, please click on the following YouTube link:

Texas Blues Jam



I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month. (More than 1.2 million health-conscious people visited Weekly Health Update in 2010!) As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.





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Cancer-Sniffing Dogs

Welcome to Weekly Health Update


“A critical weekly review of important new research findings for health-conscious readers”



Cancer-Sniffing Dogs

The earlier that cancer is detected, the greater the likelihood of cure. Therefore, cancer researchers are always looking for more sensitive tests that can detect cancer at the earliest possible stage. When I was a cancer research fellow working in the lab, I used an exquisitely sensitive chemical test to identify trace amounts of genetic material from otherwise invisible tumor cells floating in the blood or bone marrow of patients who had previously been diagnosed with cancer, and who were thought to have been cured of their disease. (This test, reverse transcriptase-polymerase chain reaction, or RT-PCR, works by “amplifying” trace amounts of genetic material using a powerful chemical reaction.)

There have been many novel strategies proposed to improve our ability to detect cancer at the earliest possible stages, but few have been more novel than the proposed use of domesticated animals to sniff-out chemicals secreted by cancerous tumors in humans. In an extremely novel cancer detection research study, which appears in the current issue of the journalGut, a specially trained Labrador retriever was employed to sniff the exhaled breath and stool samples of humans. In this innovative pilot study, this specially trained dog was directed to sniff the exhaled breath and stool samples from patient volunteers with colorectal cancer, and patient volunteers without colorectal cancer (all of these patient volunteers subsequently underwent colonoscopy to confirm the presence or absence of colorectal cancer). The results of this preliminary study are, quite simply, amazing.

When compared to the findings at colonoscopy, the “scent detection” dog was able to correctly identify colorectal cancer patients simply by smelling their breath in more than 90 percent of cases! Even more astonishing, this dog was able to accurately identify patients with colorectal cancer 98 percent of the time by sniffing their stool specimens!

Anyone who has undergone colonoscopy knows that the bowel-purging “prep” on the day before is quite unpleasant. (Colonoscopy, itself, can be rather unpleasant, although most patients are moderately sedated, and many patients will have no subsequent recollection of this scope procedure.) Moreover, colonoscopy is an expensive screening test for colorectal cancer, and like all invasive procedures, colonoscopy is associated with a small risk of complications, including bleeding and bowel perforation. Therefore, it is mind-boggling to me that, based upon the results of this very small clinical research study, a specially-trained dog proved to be virtually as accurate in diagnosing both early and advanced colorectal cancers as the “gold standard” colorectal cancer screening test, colonoscopy, merely by sniffing the breath and stool of human volunteers! (As an aside, it has been estimated that dogs have a sense of smell that is hundreds-of-thousand to millions of times more sensitive than humans.)

Of course, the dramatic findings of this intriguing pilot study will have to be validated by larger studies. That being said, the findings of this study are very exciting, and could revolutionize screening for colorectal cancer, and perhaps other types of cancers as well.

Once again, it appears that dogs have truly earned the title of “Man’s Best Friend!”

 

For a comprehensive guide to living an evidence-based cancer prevention lifestyle, order your copy of my new book, A Cancer Prevention Guide for the Human Race.  For the price of a cheeseburger, fries, and a shake, you can purchase this landmark new book, in both paperback and e-book formats, and begin living an evidence-based cancer prevention lifestyle today!

For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, A Cancer Prevention Guide for the Human Race,” from Amazon, Barnes & Noble, Books-A-Million,Vroman’s Bookstore, and other fine bookstores!

On Thanksgiving Day, 2010, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books! On Christmas Day, 2010, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list!


Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


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