High Fat Diet Decreases Metabolism and Increases Anger and Hostility



A new study finds that saturated fat decreases metabolism and physical activity, and increases anger and hostility.


 

HIGH FAT DIET DECREASES METABOLISM AND INCREASES ANGER AND HOSTILITY

As I have written about extensively in my bestselling book, A Cancer Prevention Guide for the Human Race, a diet low in saturated fat and meat products, such as the Mediterranean diet, has been linked to a decreased risk of cancer (and cardiovascular disease) when compared to the traditional Western diet, which is rich in saturated fat and meat. Now, a new study has linked a Mediterranean-type diet, low in saturated fat, to other potential health benefits, including greater levels of physical activity, a higher metabolic rate, and, somewhat surprisingly, less angry and hostile moods. This study appears in the current issue of the American Journal of Clinical Nutrition.

In this prospective randomized clinical study, 32 young adults were separated into two groups. The first group used cooking oils high in saturated fat, while the second group used cooking oils low in saturated fat and high in monounsaturated fat. After three weeks, both groups were “crossed over,” and had their cooking oils switched for an additional three weeks. (This clinical study’s “crossover” design is a powerful means of eliminating potential biases that can lead to false conclusions.) Another important aspect of this study was that all food consumed by the study’s volunteer research subjects was provided (and controlled) by the researchers. Moreover, the food provided to both groups of study volunteers was the same, and only the cooking oil differed between the two study groups.

All research volunteers were continuously assessed with regards to physical activity levels and resting metabolic rates (“resting energy expenditure”). Due to the observed differences in physical activity levels between the two groups of volunteers, the researchers also subjected study volunteers to a validated mood assessment questionnaire, to see if differences in mood might account for the significantly different levels of physical activity between the two groups of research volunteers.

The results of this intriguing prospective randomized clinical study were quite interesting. Firstly, continuous measurements of physical activity showed that the monounsaturated oil (Mediterranean-like diet) group was 12 percent more active, physically, than the saturated fat group (Western-type diet). Secondly, the resting metabolic rate of the monounsaturated oil group was almost 5 percent higher than that of the saturated fat cooking oil group, suggesting that the young adults who were consuming primarily monounsaturated fat were burning more calories at rest than the group that was using saturated fat. Finally, the monounsaturated fat group scored significantly lower on the anger-hostility scale of the mood assessment questionnaire than the volunteers who were using cooking oil containing saturated fat.

To summarize, this innovative prospective clinical research study found that a Mediterranean-like diet, low in saturated fat, was associated with increased levels of physical activity, a higher resting metabolism rate, and less anger and hostility, when compared to a Western-like diet that was rich in saturated fat. These findings add further evidence to the data that I extensively discuss in A Cancer Prevention Guide for the Human Race, showing that a Mediterranean diet low in saturated fat and meat products, and high in unsaturated oils, whole grains, fresh fruit and vegetable, fish, and poultry, is an important strategy for good health.

For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my bestselling book, “A Cancer Prevention Guide for the Human Race,” from AmazonBarnes & Noble, Books-A-Million, Vroman’s Bookstore, and other fine bookstores!

Within one week of publication, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books. Within three months of publication, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.com Top 100 New Book Releases in Cancer” list.

Join Dr. Wascher on Facebook

Additional Links for Robert A. Wascher, MD, FACS

Profile of Dr. Wascher by Oncology Times

Bio of Dr. Wascher at Cancer Treatment Centers of America

Dr. Wascher Discusses Predictions of Decreased Cancer Risk on azfamily.com

Dr. Wascher Discusses Environmental Risk Factors for Breast Cancer on Sharecare

Dr. Wascher Answers Questions About Cancer on talkabouthealth.com

Dr. Wascher Discusses Cancer Prevention Strategies on LIVESTRONG

Dr. Wascher Discusses Cancer Prevention on Newsmax

Dr. Wascher Answers Questions About Cancer Risk & Cancer Prevention on The Doctors Radio Show

Dr. Wascher Discusses Lymphedema After Breast Surgery on cancerlynx.com

Dr. Wascher Discusses Hormone Replacement Therapy & Breast Cancer Risk on cancerlynx.com

Dr. Wascher Discusses Chronic Pain After Mastectomy for Breast Cancer on cancerlynx.com

Dr. Wascher Discusses Sentinel Lymph Node Biopsy for Cancer on cancersupportivecare.com

Dr. Wascher Discusses the Role of Exercise in Cancer Prevention on Open Salon

Dr. Wascher Discusses Aspirin as a Potential Preventive Agent for Pancreatic Cancer on eHealth Forum

Dr. Wascher Discusses Obesity & Cancer Risk on eHealth Forum

Dr. Wascher Discusses the Role of Radiation Therapy in the Treatment of Breast Cancer on Sharecare

Dr. Wascher Discusses the Treatment of Stomach Cancer on Sharecare

Dr. Wascher Discusses the Management of Metastatic Cancer of the Liver on Sharecare

Dr. Wascher Discusses Obesity & Cancer Risk on hopenavigators.com

Dr. Wascher Discusses Hormone Replacement Therapy & Breast Cancer Risk on interactmd.com

Dr. Wascher Discusses Thyroid Cancer on health2fit.com

Links to Other Breaking Health News

Deadly New Bird Flu Identified in China

Infection Risk: Keeping an Eye on Your Dentist

Couple Loses 500 Pounds in Two Years

Coffee May Reduce Crash Risk for Long-Distance Drivers

Tiny Implant Tells Your Smart Phone When You Are Having A Heart Attack

Transplanted Kidney Causes Death Due to Rabies

Eating While Distracted Increases Calorie Intake

Resistant Bacteria are on the Rise

High Levels of Stress Linked to an Increase in Heart Disease Risk

Small Snacks Cut Hunger as Well as Big Snacks

Poor Sleep May Increase the Risk of Heart Failure

Deep Brain Stimulation May Help Patients with Anorexia Nervosa

Ancient Mummies Found to Have Heart Disease by CT Scan

Physically Fit Kids Do Better on Math & Reading Tests

How Melanoma Skin Cancer Evades the Immune System

Possible Link Between BPA and Asthma

Toddler May Have Been Cured of HIV (AIDS) Virus

Baby Boomers Appear Less Healthy Than Their Parents

The Biology of Love in the Brain

Millennials May be the Most Stressed-Out Generation

Even Modest Alcohol Intake Raises Cancer Risk

Why Do Boys Receive Lower Grades than Girls?

Negative Emotions and Feelings Can Damage Your Health

Canker Sore Drug Cures Obesity (At Least in Mice…)

How Technology is Changing the Practice of Medicine

New Salt Intake Guidelines for Children

High Levels of Distress in Childhood May Increase Risk of Heart Disease in Adulthood

Quitting Tobacco by Age 40 Restores a Normal Lifespan in Smokers

Cancer Death Rates Continue to Fall

Self-Help Books Improve Depression

Marines Try Mindfulness and Meditation to Reduce PTSD

Dying Nurse Volunteers Herself to Teach Nursing Students about the Dying

Regular Walks Cut Stroke Risk

Falling Asleep While Driving More Common than Previously Thought

Growing Immune Cells to Fight Cancer

Celebrity Health Fads Debunked

Thousands of Surgery Mistakes Are Still Happening Each Year

Kids with Food Allergies May Become Targets of Bullies

Obesity Among Young Children May Be Declining

Tamoxifen for 10 Years (Instead of 5 Years) Significantly Improves Breast Cancer Survival Rate

Fresh Fruits & Vegetables May Reduce Breast Cancer Risk

Satisfaction with Life May Actually Increase with Age

Brain Changes in the Elderly May Increase Susceptibility to Being Scammed

“Talking” Therapy May Help Depression When Antidepressant Medications Fail

New Egg-Free Flu Vaccine

Predicting Childhood Obesity at Birth

Inexpensive Power Foods

 


 


Dr. Wascher’s latest video:

Dark as Night, Part 1

Dark as Night, Part 1

Dark as Night, Part 1

At this time, more than 8 percent of Americans are unemployed.  According to the Bureau of Labor Statistics, however, the unemployment rate for veterans who served on active duty between September 2001 and December 2011 is more than 12 percent.  A new website, Veterans in Healthcare, seeks to connect veterans with potential employers.  If you are a veteran who works in the healthcare field, or if you are an employer who is looking for physicians, advanced practice professionals, nurses, corpsmen/medics, or other healthcare professionals, then please take a look at Veterans in Healthcare. As a retired veteran of the U.S. Army, I would also like to personally urge you to hire a veteran whenever possible.


Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


 

I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people from around the world who visit this premier global health information website every month.  Over the past 12 months, more than 2.8 million pages of high-quality medical research findings were served to the worldwide audience of health-conscious readers.  As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.


 


Bookmark and Share






































Post to Twitter

Fish Oil Improves Memory, Reduces Diabetes and Heart Disease Risk Factors



Fish Oil Improves Memory, Reduces Diabetes and Heart Disease Risk Factors


 

 

 

FISH OIL IMPROVES MEMORY, REDUCES DIABETES AND HEART DISEASE RISK FACTORS

Fish oil, which is rich in anti-inflammatory omega-3 polyunsaturated fatty acids, can play an important role in maintaining cardiovascular health.  There is also research data available to suggest that regular supplements of fish oil may improve brain function, including memory, in older patients.  Now, a recently published research paper, which appears in the Nutrition Journal, provides strong evidence that fish oil supplements can indeed improve cognitive function, while simultaneously reducing risk factors for cardiovascular disease.

In this study, 40 healthy middle-aged and elderly research volunteers underwent initial evaluation, including blood tests and cognitive function testing.  In this “placebo-controlled crossover” study, the volunteers were randomly divided into two groups.  One group received 3 grams of fish oil per day, while the other group received a placebo (sugar) pill.  After 5 weeks, the two groups of research volunteers were retested, and were then switched, or “crossed over,” with respect to the fish oil supplements and placebo pills.  After 5 additional weeks, the research volunteers were all once again retested.

Retesting of these research volunteers showed a significant improvement in memory function after taking fish oil for 5 weeks (when compared to the volunteers who were taking placebo pills).  Moreover, fish oil supplementation was also associated with a lower level of fat (triglycerides) in the blood, lower blood pressure, lower blood sugar levels, and a decrease in the level of the inflammatory protein TNF-alpha (tumor necrosis factor-alpha).

Taken together, the findings of this clinical study identified several apparent health benefits associated with daily fish oil supplements in middle-aged and elderly research volunteers, including improved memory function and improvements in multiple known risk factors for cardiovascular disease and diabetes.

 

Links to Other Breaking Health News

Flu Now in All 50 States, but New Cases Are Leveling Off

Quitting Tobacco by Age 40 Restores a Normal Lifespan in Smokers

Cancer Death Rates Continue to Fall

Self-Help Books Improve Depression

Marines Try Mindfulness and Meditation to Reduce PTSD

Dying Nurse Volunteers Herself to Teach Nursing Students about the Dying

Regular Walks Cut Stroke Risk

Falling Asleep While Driving More Common than Previously Thought

Growing Immune Cells to Fight Cancer

Celebrity Health Fads Debunked

Thousands of Surgery Mistakes Are Still Happening Each Year

New Graphic Antismoking Ads Debut in England

Kids with Food Allergies May Become Targets of Bullies

Obesity Among Young Children May Be Declining

Fresh Fruits & Vegetables May Reduce Breast Cancer Risk

Satisfaction with Life May Actually Increase with Age

Brain Changes in the Elderly May Increase Susceptibility to Being Scammed

“Talking” Therapy May Help Depression When Antidepressant Medications Fail

New Egg-Free Flu Vaccine

Graphic Cigarette Labels in Australia

Predicting Childhood Obesity at Birth

Inexpensive Power Foods


Dr. Wascher’s latest video:

Dark as Night, Part 1


Dark as Night, Part 1

Dark as Night, Part 1


At this time, more than 8 percent of Americans are unemployed.  According to the Bureau of Labor Statistics, however, the unemployment rate for veterans who served on active duty between September 2001 and December 2011 is now more than 12 percent.  A new website, Veterans in Healthcare, seeks to connect veterans with potential employers.  If you are a veteran who works in the healthcare field, or if you are an employer who is looking for physicians, advanced practice professionals, nurses, corpsmen/medics, or other healthcare professionals, then please take a look at Veterans in Healthcare. As a retired veteran of the U.S. Army, I would also like to personally urge you to hire a veteran whenever possible.

For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my bestselling book, “A Cancer Prevention Guide for the Human Race,” from AmazonBarnes & NobleBooks-A-MillionVroman’s Bookstore, and other fine bookstores!

Within one week of publication, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books. Within three months of publication, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list.




Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


 

Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


 

I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people from around the world who visit this premier global health information website every month.  Over the past 12 months, more than 2.4 million pages of high-quality medical research findings were served to the worldwide audience of health-conscious readers.  As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.


 


Bookmark and Share





































Post to Twitter

Statin Drugs May Reduce the Risk of Death Due to Cancer





 

A new study suggests that cholesterol lowering statin drugs may reduce the risk of dying of cancer.


 

 

STATIN DRUGS MAY REDUCE THE RISK OF DEATH DUE TO CANCER

As I discuss in my bestselling book, A Cancer Prevention Guide for the Human Race, cholesterol-reducing statin drugs can significantly reduce the risk of death due to cardiovascular disease in people with high cholesterol levels, and may also reduce the risk of cancer-related death.  However, the potential role of statins in preventing cancer, and cancer-associated death, remains unclear at this time, as much of the research evidence in this area, to date, has been contradictory.  At the same time, some of the known biological actions of statin drugs could conceivably play a role in reducing the risk of cancer, and reducing death rates due to cancer, through their anti-inflammatory and cholesterol reducing effects.

Now, a newly published Danish public health study, which appears in the current issue of the prestigious New England Journal of Medicine, strongly suggests that the use of statin drugs may significantly decrease the risk of death due to cancer.  In this study, the medical records of all Danish citizens diagnosed with cancer between 1995 and 2007 were reviewed.  Altogether, clinical data was available for a whopping 295,025 patients diagnosed with cancer over this 12-year period.

When the authors of this study looked at death rates due to all causes, the use of varying daily doses of statin drugs reduced the risk of death from any cause by 13 to 18 percent, when compared to death rates among patients who did not take statins.  At the same time, varying daily statin doses were also observed to reduce cancer-associated death rates by 13 to 17 percent, when compared to patients who did not take statin drugs.

In summary, the findings of this enormous public health study suggest that statin drugs may significantly decrease not only the risk of death from cardiovascular disease, but also the risk of dying from cancer as well.  Fortunately, there are more than a dozen randomized prospective clinical research trials underway at this time that are evaluating the appropriate role of statin drugs in the management of multiple types of cancer.


 

A Cancer Prevention Guide for the Human Race is now available in both printed and digital formats from all major bookstores.  Get your copy now, and begin living an evidence-based cancer prevention lifestyle!


Dr. Wascher’s latest video:

Dark as Night, Part 1

Dark as Night, Part 1

Dark as Night, Part 1


At this time, more than 8 percent of Americans are unemployed.  According to the Bureau of Labor Statistics, however, the unemployment rate for veterans who served on active duty between September 2001 and December 2011 is now more than 12 percent.  A new website, Veterans in Healthcare, seeks to connect veterans with potential employers.  If you are a veteran who works in the healthcare field, or if you are an employer who is looking for physicians, advanced practice professionals, nurses, corpsmen/medics, or other healthcare professionals, then please take a look at Veterans in Healthcare. As a retired veteran of the U.S. Army, I would also like to personally urge you to hire a veteran whenever possible.


For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my bestselling book, “A Cancer Prevention Guide for the Human Race,” from AmazonBarnes & NobleBooks-A-MillionVroman’s Bookstore, and other fine bookstores!

Within one week of publication, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books. Within three months of publication, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list.




Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


 

Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


 

I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people from around the world who visit this premier global health information website every month.  (More than 1.3 million pages of high-quality medical research findings were served to the worldwide audience of health-conscious people who visited Weekly Health Update in 2011!)  As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.


 



Bookmark and Share





































Post to Twitter

New Link to Diabetes, Cardiovascular Disease, Breast Cancer and Obesity in Women





 

A new study finds that high levels of the hormone neurotensin increase a woman’s risk of diabetes, cardiovascular disease, breast cancer, and possibly obesity as well.


 

NEW LINK TO DIABETES, CARDIOVASCULAR DISEASE, BREAST CANCER AND OBESITY IN WOMEN

As I discuss in my book, A Cancer Prevention Guide for the Human Race, both obesity and diabetes are associated with an increased risk of cancer.  Obesity, in particular, is a potent risk factor for breast cancer, and for recurrence of previously diagnosed breast cancer.  As I have noted recently, diabetes is also a known risk factor for breast cancer (Diabetes Significantly Increases Breast Cancer Risk).  Additionally, obesity is the single greatest risk factor for diabetes.

In view of the known associations between obesity, diabetes cardiovascular disease and cancer risk, a newly published prospective clinical research study from Sweden provides tantalizing evidence of at least one possible explanation for these associations.  In this study, 4,632 participants in the Malmö Diet and Cancer Study were followed between 1991 and 2009.  Upon entry into this prospective public health study, all participants underwent blood testing for proneurotensin, a precursor of the hormone neurotensin.  Neurotensin is most commonly found in the brain and the gastrointestinal tract, and its secretion is stimulated by food intake, and particularly by fat intake.  Neurotensin has many known physiological effects, including a reduction in appetite and food intake after meals.  Interestingly, neurotensin levels normally rise after consumption of a fatty meal, which is thought to result in a decreased appetite for more food, and reduced food intake.  However, in obese patients, neurotensin levels appear to actually decrease after consumption of a fatty meal, which suggests that an abnormal neurotensin response to food intake may play an important role in obesity.  Moreover, following obesity surgery, neurotensin levels have been observed to rise, in a normal fashion, following fatty meals.  Additionally, neurotensin has been observed to stimulate the growth of breast cancer tumors, while blocking neurotensin appears to reduce breast cancer tumor growth.  Finally, certain inherited variations of one of the receptors for neurotensin is known to increase the risk of cardiovascular disease, primarily by increasing levels of LDL cholesterol (the “bad” form of cholesterol).

The findings of this study were very intriguing.  Among patients with elevated levels of proneurotensin, diabetes was 28 percent more common, cardiovascular disease was 17 percent more common, and death due to cardiovascular disease was 29 percent more common.  Interestingly, the adverse health impact of high proneurotensin levels was significant only in women. Among women only, high levels of proneurotensin were associated with a 41 percent increase in the risk of diabetes, a 33 percent increase in the risk of cardiovascular disease, a 50 percent increase in the risk of death due to cardiovascular disease, a 44 percent increase in the risk of breast cancer, and a 13 percent overall increase in the risk of death due to any cause.

This study was published in the Journal of the American Medical Association.

While this study cannot explain the actual mechanism(s) whereby increased levels of proneurotensin and neurotensin may lead to an increased risk of diabetes, cardiovascular disease, and breast cancer in women, it nonetheless suggests that these hormones, when elevated, should be considered as markers for an increased risk of these serious illnesses, at least in women.  Moreover, based upon our knowledge of the physiological effects of neurotensin on digestion and appetite control, and its abnormal secretion in obese women, it is possible that stimulating an increase in neurotensin levels may help to restore more normal appetite levels, decrease caloric intake, and improve weight loss in obese patients.

More research needs to be done in order to understand how proneurotensin and neurotensin play a role in the development of obesity, diabetes, cardiovascular disease, and cancer.  In doing so, we may be able to open up exciting new opportunities to reduce the incidence and impact of these common causes of premature death, particularly among women.

 

A Cancer Prevention Guide for the Human Race is now available in both printed and digital formats from all major bookstores.  Get your copy now, and begin living an evidence-based cancer prevention lifestyle now!

 

Dr. Wascher’s latest video:

Dark as Night, Part 1


Dark as Night, Part 1

Dark as Night, Part 1



At this time, more than 8 percent of Americans are unemployed.  According to the Bureau of Labor Statistics, however, the unemployment rate for veterans who served on active duty between September 2001 and December 2011 is now more than 12 percent.  A new website, Veterans in Healthcare, seeks to connect veterans with potential employers.  If you are a veteran who works in the healthcare field, or if you are an employer who is looking for physicians, advanced practice professionals, nurses, corpsmen/medics, or other healthcare professionals, then please take a look at Veterans in Healthcare. As a retired veteran of the U.S. Army, I would also like to personally urge you to hire a veteran whenever possible.


For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my bestselling book, “A Cancer Prevention Guide for the Human Race,” from AmazonBarnes & NobleBooks-A-MillionVroman’s Bookstore, and other fine bookstores!

Within one week of publication, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books. Within three months of publication, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list.




Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


 

Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


 

I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people from around the world who visit this premier global health information website every month.  (More than 1.3 million pages of high-quality medical research findings were served to the worldwide audience of health-conscious people who visited Weekly Health Update in 2011!)  As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.


 



Bookmark and Share





































Post to Twitter

Common Household Chemical May Double Heart Disease Risk





 

A new clinical study finds that a common household chemical (perfluorooctanoic acid) may double the risk of heart disease.


 

 

COMMON HOUSEHOLD CHEMICAL MAY DOUBLE HEART DISEASE RISK

Cardiovascular disease continues to be one of the most common causes of disability and death, accounting for one out of every four deaths in the United States.  The most common risk factors for cardiovascular disease are well known, and include lack of physical activity, obesity, high blood pressure, smoking, elevated cholesterol, and diabetes.  Additionally, a strong family history of cardiovascular disease, particularly at an early age, also increases one’s risk of cardiovascular disease.  Now, a newly published research study raises the possibility that a manmade chemical commonly found in household products may also significantly increase the risk of cardiovascular disease.  This new study appears in the current issue of the Archives of Internal Medicine.

Perfluorooctanoic acid (PFOA) appears in numerous household products, including carpet-care products, clothing, floor-care products, non-stick surfaces in cookware and paper food-wrapping products, polishes, dental floss, and implantable medical devices, among others.  In fact, PFOA is so ubiquitous in the United States that it is detectable in the blood of 98 percent of the population.  Moreover, once ingested, PFOA remains in the human body for many years, and can therefore accumulate at increasingly higher levels over time.

In addition to being a known carcinogen, PFOA has been previously linked with cardiovascular disease in animal studies.  Therefore, this new clinical study was designed to assess the association between cardiovascular disease and blood levels of PFOA in humans.  In this clinical study, 1,216 volunteers were recruited from the ongoing National Health and Nutritional Examination Survey (NHANES) prospective public health study, and were tested for the level of PFOA in their blood.  They also underwent both extensive surveys regarding their health and physical examinations for signs of peripheral arterial disease.  Importantly, known risk factors for cardiovascular and peripheral artery disease were assessed in each of these volunteers, and this information was used to improve the accuracy of the study’s conclusions regarding PFOA and the risk of cardiovascular and peripheral arterial disease.

Even after correcting for preexisting risk factors for cardiovascular and peripheral arterial disease, this study found a significant association between PFOA levels in the blood and the incidence of cardiovascular disease and peripheral arterial disease.  When comparing volunteers with the lowest and highest levels of PFOA, patients with the highest levels of POFA were found to have two times the risk of developing cardiovascular disease and almost twice the risk of developing peripheral arterial disease.  Once again, the association between PFOA levels in the blood and the risk of cardiovascular and peripheral arterial disease remained even after correcting for gender, age, race/ethnicity, smoking status, obesity, diabetes, high blood pressure and elevated cholesterol levels.

While the findings of this study will have to be verified by additional and larger prospective clinical studies, these findings do nonetheless raise concerns that PFOA may, itself, be an independent cause of cardiovascular and peripheral vascular disease.  Given that almost every adult in the United States has at least some measurable concentration of PFOA in their blood, even a small associated increase in the risk of cardiovascular and peripheral vascular disease could have a significant impact on the overall incidence of these diseases within the larger population.  According to the Centers for Disease Control (CDC), approximately 40 percent of adult Americans already have at least two conventional cardiovascular disease risk factors.  However, given that PFOA is present in virtually everyone’s body, our risk of cardiovascular and peripheral artery disease may actually be significantly higher than previously appreciated, based upon the findings of this important new clinical study.

 

At this time, more than 8 percent of Americans are unemployed.  According to the Bureau of Labor Statistics, however, the unemployment rate for veterans who served on active duty between September 2001 and December 2011 is now more than 12 percent.  A new website, Veterans in Healthcare, seeks to connect veterans with potential employers.  If you are a veteran who works in the healthcare field, or if you are an employer who is looking for physicians, advanced practice professionals, nurses, corpsmen/medics, or other healthcare professionals, then please take a look at Veterans in Healthcare. As a retired veteran of the U.S. Army, I would also like to personally urge you to hire a veteran whenever possible.


For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my bestselling book, “A Cancer Prevention Guide for the Human Race,” from AmazonBarnes & NobleBooks-A-MillionVroman’s Bookstore, and other fine bookstores!

Within one week of publication, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books. Within three months of publication, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list.




Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


 

Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


 

I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people from around the world who visit this premier global health information website every month.  (More than 1.3 million pages of high-quality medical research findings were served to the worldwide audience of health-conscious people who visited Weekly Health Update in 2011!)  As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.


 






Bookmark and Share





































Post to Twitter

Statin Drugs Reduce Heart Attacks and Strokes Even in Low-Risk Patients





 

 

A pivotal new study concludes that statin drugs sharply reduce the risk of heart attack and stroke even in patients who are at low risk for cardiovascular disease.




 

 

STATIN DRUGS REDUCE HEART ATTACKS AND STROKES EVEN IN LOW-RISK PATIENTS

The cholesterol-lowering drugs known as “statins” are among the most commonly prescribed medications in the world, and they have been credited with sharply reducing the risk of death due to cardiovascular disease, including coronary artery disease, peripheral vascular disease, and stroke.  The statin drugs work primarily by lowering blood levels of LDL cholesterol (the “bad” cholesterol), thus reducing the risk of developing the arterial plaques that cause cardiovascular disease.

There is a huge body of research data showing that statin drugs reduce death rates due to cardiovascular disease in patients with elevated levels of LDL cholesterol, including patients with only mildly-to-moderately elevated LDL cholesterol levels. However, there have also been several intriguing public health studies that have suggested a potential benefit associated with statin drugs even in patients with normal LDL cholesterol levels.  Despite these research findings, however, there has been a general reluctance to prescribe statin drugs to patients with normal LDL levels, or to patients with mildly elevated LDL levels, particularly as statin drugs, like all medications, are associated with known side effects, including potential injury to the muscles, liver and kidneys, as well as a possible increase in the risk of diabetes.  Now a massive new research study, which appears in an early-release edition of the journal Lancet, may lead to a wholesale change in the way that physicians prescribe statin drugs.

This newly published study, a meta-analysis study, combined and analyzed the data from 27 different statin research studies, which included nearly 175,000 adult research participants, making this an enormously powerful research study.  In this study LDL cholesterol levels were measured, and the impact of statin drugs on the incidence of heart attacks (myocardial infarction) and stroke, and death due to cardiovascular disease, was observed.  Study participants were grouped into five different categories, based upon their estimated 5-year “cardiovascular event” risk, ranging from less than 5 percent to greater than 30 percent 5-year risk.  This risk assessment was, in turn, calculated using LDL cholesterol levels, age, gender, blood pressure, and lifestyle factors such as tobacco use and physical activity levels.

Not surprisingly, the use of statins decreased the risk of cardiovascular events, on average, by about 21 percent for every 1 mmol/liter reduction in LDL cholesterol among the entire volunteer group of nearly 175,000 study participants.  What is particularly important about this study’s findings, however, is that the study participants in the two lowest risk groups experienced at least as much (if not more) benefit, in terms of reducing the risk of heart attack and stroke, as did the participants in the higher risk groups.  For example, patients with a calculated 5-year risk of heart attack or stroke of less than 5 percent experienced a 38 percent reduction in the risk (for every1 mmol/liter reduction in LDL cholesterol) of either of these cardiovascular events, while patients with a calculated 5-year risk of 30 percent or higher experienced a 21 percent reduction (for every1 mmol/liter reduction in LDL cholesterol) in the risk of a major cardiovascular event.

When looking at heart attack or death due to heart attack, specifically, the study participants with a 5-year predicted risk of heart attack or stroke of less than 5 percent experienced an enormous reduction in the risk of heart attack or death due to heart attack (43 percent for every1 mmol/liter reduction in LDL cholesterol) while taking statin drugs.  This same low-risk group, when taking statins, also had a 48 percent reduction (for every1 mmol/liter reduction in LDL cholesterol) in the likelihood that they would have to undergo surgical procedures to stent or bypass blocked coronary arteries.

The risk of stroke was also significantly reduced in both low-risk and high-risk study participants.  For example, patients with a calculated 5-year risk of major cardiovascular events of less than 10 percent were 24 percent less likely to have a stroke (for every1 mmol/liter reduction in LDL cholesterol) if they were taking a statin drug, which was similar to the reduction in stroke risk that was observed in the higher risk patients.

The public health implications of this very large study’s findings are highly significant.  For the first time, this study provides extremely compelling data that even patients who are at low risk of suffering a heart attack or stroke may derive as much, or perhaps even more, benefit from taking a statin drug when compared to patients who are high or very high risk of experiencing these major cardiovascular events.  When measured against the known risks of the adverse side effects of statin drugs, this study still showed an overwhelming health benefit associated with statin drugs in both patients at low-risk for cardiovascular disease and in high-risk patients.  It will now fall to public health experts, internists, cardiologists and family practice physicians to incorporate the findings of this exceptionally compelling, and powerful, meta-analysis study into their management of adult patients, and particularly those over the age of 50, even if these patients are predicted to be at low risk for heart attack and stroke.  I see this research study as a health care game changer, and I predict that it will, eventually, dramatically alter the current prescribing patterns for statin drugs.  (As always, I recommend that you consult your physician before starting any new medication or dietary supplement, including statin drugs.)


 

For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my bestselling book, “A Cancer Prevention Guide for the Human Race,” from AmazonBarnes & NobleBooks-A-MillionVroman’s Bookstore, and other fine bookstores!

Within one week of publication, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books. Within three months of publication, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list.



Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people from around the world who visit this premier global health information website every month.  (More than 1.3 million pages of high-quality medical research findings were served to the worldwide audience of health-conscious people who visited Weekly Health Update in 2011!)  As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.


 





Bookmark and Share





































Post to Twitter

New Vaccine and Antibodies May Prevent Heart Disease





 

New studies suggest that heart disease may someday become preventable with vaccine and antibody therapy.


 

 

NEW VACCINE AND ANTIBODIES MAY PREVENT HEART DISEASE

As I discuss in my bestselling book, A Cancer Prevention Guide for the Human Race, cancer has recently surpassed cardiovascular disease to become the #1 cause of death in many areas of the world.  However, coronary artery disease, peripheral vascular disease and stroke continue to kill millions of people around the world every year.

In general, atherosclerotic artery disease arises when thick “plaques” develop on the inner walls of arteries.  These plaques can rupture, thus exposing their inner surfaces, which can then activate the components of the blood responsible for forming blood clots.  The progression of blood clots on the surface “atheromatous” plaques within the arteries of the heart and brain can directly cause blockage of affected arteries, leading to a heart attack or stroke, respectively.  Even more commonly, however, clumps of clot and atheromatous plaque can break off and travel downstream, where they block coronary artery and brain artery branches, causing heart attacks (myocardial infarction) and strokes, respectively.  As inflammation, caused by our bodies’ white blood cells and antibodies, plays an important role in the development of atherosclerosis, scientists have been testing both vaccines and blocking antibodies in laboratory animals in an effort to prevent (or even reverse) the development of atherosclerosis, in the hope that heart attacks and strokes (and limb loss, in the case of peripheral vascular disease) can be prevented.

Two experimental new approaches to preventing and treating cardiovascular disease were unveiled at the Frontiers in Cardiovascular Biology conference this past week in London, and they have generated a great deal of interest among cardiovascular disease experts around the world.

In one recent study, which was performed using laboratory mice, an experimental vaccine (“CVX-210”) that reprograms inflammatory white bloods cells into inflammation-fighting white blood cells was evaluated.  In this mouse study, the CVX-210 vaccine was able to reduce the extent of arterial atherosclerosis by 60 to 70 percent!  While treatments that are effective in laboratory mice do not always work in humans, the manufacturer of the CVX-210 vaccine, CardioVax, is currently awaiting FDA approval to begin preliminary human clinical trials.

A second immunological approach to the prevention and treatment of arterial atherosclerosis involves the use of blocking antibodies that are designed to target oxidized LDL cholesterol (the “bad cholesterol,” which is a major component of atherosclerotic plaques, and which also participates in the inflammatory cascade that leads directly to plaque formation.)  When injected into a patient, these antibodies attack oxidized LDL particles and, theoretically, block the formation of atherosclerotic plaques.  At this time, there is an ongoing human clinical trial that is evaluating this “BI-204” human monoclonal antibody.  (In preclinical studies, BI-204 has already been shown to decrease the extent of existing arterial atherosclerotic plaques in laboratory animals by as much as 50 percent!)

In addition to the potential of the CVX-210 vaccine and the BI-204 human monoclonal antibody to significantly reduce, and possibly prevent, arterial atherosclerosis, these two still experimental therapies, if proven to be safe and effective in humans, would also be available for use in combination with current cardiovascular disease prevention therapies, including the cholesterol blocking statin drugs, high blood pressure medications, and diabetes medications.  (When considered together, these three current, conventional treatments for the most common risk factors for cardiovascular disease are estimated to reduce the risk of heart attack by about 40 percent.)  Because all of these therapies target different risk factors for cardiovascular disease, combining CVX-210 and/or BI-204 with current conventional cardiovascular disease prevention therapies could dramatically further reduce our risk of cardiovascular disease and significantly prolong our lives in the future.

As a disease prevention expert, I consider these two new developments to be of potentially enormous importance in the area of cardiovascular disease prevention and treatment.  Given that inflammation is known to play an important role in the development of both cardiovascular disease and cancer, I will be very interested to see if these two new experimental approaches to cardiovascular disease prevention and treatment also have a beneficial risk on cancer risk as well!



For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my bestselling book, “A Cancer Prevention Guide for the Human Race,” from AmazonBarnes & NobleBooks-A-MillionVroman’s Bookstore, and other fine bookstores!

Within one week of publication, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books. Within three months of publication, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list.


Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


For a lighthearted perspective on Dr. Wascher, please click on the following YouTube link:

Texas Blues Jam


I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people from around the world who visit this premier global health information website every month.  (More than 1.3 million pages of high-quality medical research findings were served to the worldwide audience of health-conscious people who visited Weekly Health Update in 2011!)  As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.


 





Bookmark and Share





































Post to Twitter

The Four Critical Cardiovascular Disease Risks That You Can Change

Welcome to Weekly Health Update



New research shows that high blood pressure, high cholesterol, diabetes, and smoking account for the vast majority of all deaths caused by cardiovascular disease.


 

THE FOUR CRITICAL CARDIOVASCULAR DISEASE RISKS THAT YOU CAN CHANGE

As I mention in my recent bestselling book, A Cancer Prevention Guide for the Human Race, many of the very same lifestyle and dietary habits that increase our risk of developing cancer also increase our risk of developing cardiovascular disease, including coronary artery disease, heart attacks (myocardial infarction), peripheral vascular disease, and stroke.  Likewise, adopting an evidence-based cancer prevention lifestyle can not only cut your cancer risk in half, but can also significantly reduce your risk of developing life-threatening cardiovascular disease as well.

A newly published research study, which was funded by the National Institutes of Health, provides, for the first time, a comprehensive assessment of the lifetime risks of developing cardiovascular disease based upon the following four health-related factors: blood pressure, cholesterol (lipid) levels in the blood, smoking status, and diabetes status.  Importantly, this huge meta-analysis study, which appears in the current issue of the New England Journal of Medicine, comprehensively analyzes the data from 18 different prior clinical research studies, which included 257,384 adult black and white men and women.  These research volunteers were assessed for these four critical cardiovascular risk factors every 10 years, beginning at age 45 and ending at age 75.  This enormous group of research volunteers was then closely followed, and the incidence of cardiovascular disease and death rates due to cardiovascular disease were then carefully evaluated and analyzed.

When looking at cardiovascular risks factors at age 55 as predictors of future cardiovascular disease risk, and the risk of death due to cardiovascular disease, the findings of this extremely large clinical study were striking.  In this study, a low-risk profile for cardiovascular disease was defined as total blood cholesterol less than 180 milligrams per deciliter (4.7 mmol per liter), average blood pressure less than 120/80 millimeters of mercury (mm Hg), nonsmoker status, and nondiabetic status.

Among the 55 year-old men and women who met all of the criteria for a low-risk profile for cardiovascular disease, their lifetime incidence of cardiovascular disease, through age 80, was remarkably lower than for the 55 year-olds who failed to meet two or more of the four low-risk criteria.  In fact, the risk of death due to cardiovascular disease, through age 80, was only 5 percent among the men who met all four low-risk criteria at age 55, while the men who met only two or fewer low-risk criteria faced a dramatic six-fold increase in the risk (30 percent) of dying of cardiovascular disease by age 80.  Among the women volunteers, only 6 percent of the women who met all four low-risk criteria went on to die of cardiovascular disease by age 80, while 21 percent of the women who failed to meet two or more of the four low-risk criteria died of cardiovascular disease between age 55 and age 80 (for a nearly four-fold increase in the risk of death).

Fatal and nonfatal coronary artery disease occurred in only 4 percent of the men who met all four low-risk criteria, but occurred in nearly 10 times as many of the men (38 percent) who failed to meet two or more of these four criteria.  The women who met all four low-risk criteria faced a less than 1 percent risk of fatal and nonfatal coronary artery disease, while the women who met two or fewer low-risk criteria experienced an 18 percent incidence of fatal and nonfatal coronary artery disease (for a more than 18-fold increase in risk).

The risk of fatal and nonfatal stroke was also significantly lower among men and women who met all four low-risk criteria for cardiovascular disease.  Among the men who met all four low-risk criteria, the incidence of stroke through age 80 was only about 2 percent, but quadrupled, to more than 8 percent, among the men who failed to meet two or more of the four low-risk criteria.  Among the women who met all four low-risk criteria, the incidence of stroke was about 5 percent, but more than doubled, to nearly 11 percent, among the women who failed to meet at least two of the low-risk criteria.

The findings of this very large study cannot be overstated in terms of its public health importance, as this is the only study that has prospectively assessed very large numbers of men and women, including both black and white adults, over long periods of time, and that has analyzed the long-term impact of the four most common risk factors for cardiovascular disease on incidence and death rates associated with cardiovascular disease.  As with the studies that I discuss in A Cancer Prevention Guide for the Human Race, the impact of lifestyle, diet, and other modifiable health-related factors on both cardiovascular disease risk and cancer risk is enormous, particularly when measured over the lifespan of the average adult.

The findings of this epic public health research study also add further weight to my strong belief, based upon my review of thousands of research studies, that we, as individuals, hold the key to improving our health, and to significantly reducing our risk of serious illness and premature death, by living evidence-based healthy lifestyles.  If your blood pressure is high, change your diet and increase your level of exercise, with the support of your doctor.  If diet and physical activity interventions alone do not correct your hypertension, then ask your doctor about medications for high blood pressure.  If you have diabetes, you also need to change your diet, increase your levels of physical activity, and safely lose any excess weight.  If these lifestyle changes do not completely resolve your high blood sugars, then you may also need to ask your doctor about medications for diabetes.  If you smoke, or use smokeless tobacco, stop immediately.  Finally, if your LDL and total cholesterol levels are high, then, once again, you need to be more careful about what you eat.  (The cancer-preventing foods and diets that I discuss in my book have also been linked to lower levels of blood cholesterol, as well as a much lower risk of cardiovascular disease.)  You may also need to increase your physical activity levels, and get your weight down to a healthy level, to improve your LDL and total cholesterol levels.  Once again, if these prudent lifestyle measures are not enough, by themselves, to bring your cholesterol levels down into the normal range, then your doctor may need to add a cholesterol-lowering medication as well.

The striking results of this important cardiovascular disease prevention study provide all of us with the key to maximally reducing our risk of developing—and dying from—largely preventable cardiovascular diseases, including heart disease and stroke.  Better long-term health (and a longer and more vigorous life) is within your grasp, and this study, in addition to my book, can show you the way forward.


For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, “A Cancer Prevention Guide for the Human Race,” from AmazonBarnes & NobleBooks-A-MillionVroman’s Bookstore, and other fine bookstores!

On Thanksgiving Day, 2010, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books! On Christmas Day, 2010, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list!



Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


For a different perspective on Dr. Wascher, please click on the following YouTube link:

Texas Blues Jam


I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people from around the world who visit this premier global health information website every month.  (More than 1.3 million pages of high-quality medical research findings were served to the worldwide audience of health-conscious people who visited Weekly Health Update in 2011!)  As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.


 








Bookmark and Share



Post to Twitter

Enter Google AdSense Code Here

Comments

Better Tag Cloud