Every Other Day Aspirin Reduces Colorectal Cancer Risk



A large new prospective study finds that every-other-day low-dose aspirin significantly reduces colorectal cancer risk.


 

EVERY OTHER DAY ASPIRIN REDUCES COLORECTAL CANCER RISK

As I discuss in my bestselling book, A Cancer Prevention Guide for the Human Race, aspirin has been shown, by numerous studies, to reduce the risk of colorectal cancer.  However, daily aspirin use is not without its risks, including GI tract ulceration and bleeding.  Now, a newly published study suggests that low-dose aspirin, when taken every other day, may still significantly reduce colorectal cancer risk.  This new study appears in the current issue of the Annals of Internal Medicine.

This study is part of the prospective Women’s Health Study, and included 33,682 adult female health professionals who volunteered to participate in this large and ongoing prospective randomized clinical trial.  Study participants were secretly randomized to receive either 100 mg of aspirin every other day or an identical-appearing placebo pill in this double-blinded placebo-controlled trial.  Follow-up in this very large prospective study averaged nearly 10 years.

During the decade-long course of this clinical study, 5,071 participants were diagnosed with cancer, and 1,391 of the study volunteers died of cancer.

The use of every-other-day aspirin had no apparent impact on the risk of cancers of the breast or lung.  However, every-other-day low-dose aspirin use was associated with a rather dramatic 42 percent reduction in colorectal cancer risk among the women who were followed for the longest duration in this study.

This high-powered prospective, randomized, blinded, placebo-controlled clinical trial adds to an already large body of evidence showing that the daily use of low-dose aspirin can significantly reduce colorectal cancer use.  In the case of this study, however, taking low-dose aspirin every other day still yielded a very impressive reduction in colorectal cancer risk.  At the same time, even every-other-day dosing of aspirin was still associated with a measurable increase in the risk of aspirin’s known side effects, including a 14 percent increase in the risk of GI tract bleeding and a 17 percent increase in the risk of GI tract ulcers.

The findings of this important prospective, randomized, controlled clinical trial suggest that low-dose aspirin does not have to be taken every single day to provide significant colorectal prevention benefits.  However, in view of the aspirin-associated GI tract side effects noted in this study, even with every-other-day use, it is important that you consult your personal physician before you start taking aspirin.

For more information on this and other evidence-based approaches to cancer prevention, obtain your copy of A Cancer Prevention Guide for the Human Race.

 

For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my bestselling book, “A Cancer Prevention Guide for the Human Race,” from AmazonBarnes & Noble, Books-A-Million, Vroman’s Bookstore, and other fine bookstores!

Within one week of publication, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books. Within three months of publication, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.com Top 100 New Book Releases in Cancer” list.

 

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CNN Story on CTCA’s Organic Farm in the Phoenix Area

Dr. Wascher Discusses Signs & Symptoms of Skin Cancer

Profile of Dr. Wascher by Oncology Times

Bio of Dr. Wascher at Cancer Treatment Centers of America

Dr. Wascher Discusses Predictions of Decreased Cancer Risk on azfamily.com

Dr. Wascher Discusses Environmental Risk Factors for Breast Cancer on Sharecare

Dr. Wascher Answers Questions About Cancer on talkabouthealth.com

Dr. Wascher Discusses Cancer Prevention Strategies on LIVESTRONG

Dr. Wascher Discusses Cancer Prevention on Newsmax

Dr. Wascher Answers Questions About Cancer Risk & Cancer Prevention on The Doctors Radio Show

Dr. Wascher Discusses Lymphedema After Breast Surgery on cancerlynx.com

Dr. Wascher Discusses Hormone Replacement Therapy & Breast Cancer Risk on cancerlynx.com

Dr. Wascher Discusses Chronic Pain After Mastectomy for Breast Cancer on cancerlynx.com

Dr. Wascher Discusses Sentinel Lymph Node Biopsy for Cancer on cancersupportivecare.com

Dr. Wascher Discusses the Role of Exercise in Cancer Prevention on Open Salon

Dr. Wascher Discusses Aspirin as a Potential Preventive Agent for Pancreatic Cancer on eHealth Forum

Dr. Wascher Discusses Obesity & Cancer Risk on eHealth Forum

Dr. Wascher Discusses the Role of Radiation Therapy in the Treatment of Breast Cancer on Sharecare

Dr. Wascher Discusses the Treatment of Stomach Cancer on Sharecare

Dr. Wascher Discusses the Management of Metastatic Cancer of the Liver on Sharecare

Dr. Wascher Discusses Obesity & Cancer Risk on hopenavigators.com

Dr. Wascher Discusses Hormone Replacement Therapy & Breast Cancer Risk on interactmd.com

Dr. Wascher Discusses Thyroid Cancer on health2fit.com

 

Links to Other Breaking Health News

HPV Virus Newly Linked to One-Third of All Oral Cancer Cases

FDA Approves New Brain Scan to Assess for ADHD in Kids

Epidemic of Drug Overdose Deaths Among Middle-Aged Women

Man Loses 155 Pounds

Naked Mole Rat May Provide Important Cancer Prevention Clue

The Effects of Poverty on the Brain

Half of Us Will Develop Cancer in Our Lifetimes

Protein Critical for Long-Term Memory Identified

HPV Virus and Cancer Risk

Probiotics May Decrease Antibiotic-Associated Diarrhea caused by C. difficile

3-D Printer Helps to Save Baby’s Life

Experimental Drug May Reduce Heart Damage after Heart Attack

Vitamin D May Improve Asthma Symptoms

Doctor Provides Patients with Own Feces for Fecal Transplants

Rising Arsenic Levels in Chicken

Dramatic Increase in Suicide Rate Among Middle Aged Americans Over the Past Decade

Cutting Umbilical Cord Too Soon May Cause Anemia in Newborns

Spiny New Bandage May Speed Healing of Skin Wounds

Study Confirms that Men Really Do Have Trouble Reading the Thoughts of Women

Deadly new Bird Flu Strain Cases Continue to Rise

Abdominal Fat Increases Kidney Disease Risk

Increasing Dietary Potassium & Decreasing Salt Intake Reduces Stroke Risk

A New Explanation for the Link Between Red Meat & Cardiovascular Disease

Deadly New Bird Flu Identified in China

Infection Risk: Keeping an Eye on Your Dentist

Couple Loses 500 Pounds in Two Years

Coffee May Reduce Crash Risk for Long-Distance Drivers

Tiny Implant Tells Your Smart Phone When You Are Having A Heart Attack

Transplanted Kidney Causes Death Due to Rabies

Eating While Distracted Increases Calorie Intake

Resistant Bacteria are on the Rise

High Levels of Stress Linked to an Increase in Heart Disease Risk

Small Snacks Cut Hunger as Well as Big Snacks

Poor Sleep May Increase the Risk of Heart Failure

Ancient Mummies Found to Have Heart Disease by CT Scan

Physically Fit Kids Do Better on Math & Reading Tests

How Melanoma Skin Cancer Evades the Immune System

Possible Link Between BPA and Asthma

Baby Boomers Appear Less Healthy Than Their Parents

The Biology of Love in the Brain

Millennials May be the Most Stressed-Out Generation

Even Modest Alcohol Intake Raises Cancer Risk

Why Do Boys Receive Lower Grades than Girls?

Negative Emotions and Feelings Can Damage Your Health

Canker Sore Drug Cures Obesity (At Least in Mice…)

How Technology is Changing the Practice of Medicine

New Salt Intake Guidelines for Children

High Levels of Distress in Childhood May Increase Risk of Heart Disease in Adulthood

Quitting Tobacco by Age 40 Restores a Normal Lifespan in Smokers

Cancer Death Rates Continue to Fall

Self-Help Books Improve Depression

Marines Try Mindfulness and Meditation to Reduce PTSD

Dying Nurse Volunteers Herself to Teach Nursing Students about the Dying

Regular Walks Cut Stroke Risk

Falling Asleep While Driving More Common than Previously Thought

Celebrity Health Fads Debunked

Obesity Among Young Children May Be Declining

Fresh Fruits & Vegetables May Reduce Breast Cancer Risk

Satisfaction with Life May Actually Increase with Age

Brain Changes in the Elderly May Increase Susceptibility to Being Scammed


 


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According to recent Bureau of Labor Statistics, the unemployment rate for veterans who served on active duty between September 2001 and December 2011 is more than 12 percent. Veterans in Healthcare seeks to connect veterans with potential employers.  If you are a veteran who works in the healthcare field, or if you are an employer who is looking for physicians, advanced practice professionals, nurses, corpsmen/medics, or other healthcare professionals, then please take a look at Veterans in Healthcare. As a retired veteran of the U.S. Army, I would also like to personally urge you to hire a veteran whenever possible.


Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


 

I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people from around the world who visit this premier global health information website every month.  Over the past 12 months, 3.5 million pages of high-quality medical research findings were served to the worldwide audience of health-conscious readers.  As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.


 


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Aspirin Dramatically Reduces Prostate Cancer Death Rate






 

A new study shows that aspirin reduces the risk of death from prostate cancer by 60 to 80%.


 

ASPIRIN DRAMATICALLY REDUCES PROSTATE CANCER DEATH RATE

 

Prostate cancer is the most common of all major cancers in men, and the second most common cause of cancer-associated death in men.  Based upon data from the American Cancer Society, 242,000 men will be diagnosed with prostate cancer in the United States in 2012, and more than 28,000 American men will die of this disease this year.

 

As I discuss in my bestselling book, A Cancer Prevention Guide for the Human Race, there are multiple evidence-based strategies available for men to decrease their risk of developing prostate cancer.  However, one area where prostate cancer prevention research in humans has been lacking is in the assessment of non-steroidal anti-inflammatory (NSAID) medications for the prevention and treatment of prostate cancer.  There is abundant scientific evidence that this class of medications (which includes aspirin, ibuprofen, naproxen, and other common anti-inflammatory drugs) can significantly reduce the risk of other types of cancer, including, notably, colon and rectal cancer.  Now, a new study involving nearly 6,000 men with prostate cancer indicates that the humble aspirin tablet appears to dramatically reduce the risk of cancer-associated death in men diagnosed with prostate cancer.

 

The prospective Cancer of the Prostate Strategic Urologic Research Endeavor (CaPSURE) Study enrolled 5,955 men with early-stage prostate cancer.  All of these men underwent either surgery (prostatectomy) or radiation therapy as primary treatment for their prostate cancer.  Among these nearly 6,000 patient volunteers, 2,175 were taking one or more blood thinning medications for other illnesses, including aspirin, Coumadin (warfarin), Plavix (clopidogrel), or Lovenox (enoxaprin).  The outcomes of these nearly 6,000 prostate cancer patients were carefully monitored over an average follow-up period of 70 months.  Importantly, throughout the course of this large prospective clinical study, patients were required to provide updated health information on a quarterly basis.  Moreover, their Urologists also separately provided ongoing clinical updates on these patients.  This unique study design, along with its prospective nature and its large cohort of patient volunteers, provides a very high level of clinical evidence for this study’s findings.

 

The results of this study were striking.  While the non-aspirin blood thinners appeared to have minimal impact on the death rate due to prostate cancer, the regular use of aspirin was associated with a whopping and highly significant 57 percent reductionin the risk of death due to prostate cancer among these nearly 6,000 patient volunteers.  Even more impressive was the finding that men with high-risk forms of prostate cancer were almost 5 times less likely to die of prostate cancer if they took aspirin (i.e., 4 percent risk of death versus 19 percent risk of death at 10 years, respectively), which equates to a nearly 80 percent reduction in the risk of dying from prostate cancer.

 

The findings of this study have significant public health implications.  For men already diagnosed with prostate cancer, and especially men who have prostate cancer with high-risk features, aspirin appears to dramatically reduce the risk of cancer-associated death for a period of at least 10 years, based upon the findings of this ongoing study.  Additionally, this finding that aspirin dramatically reduces the risk of cancer-associated death in men diagnosed with prostate cancer also strongly suggests that there may also be a role for aspirin as a prevention agent for prostate cancer, much as it is currently used to prevent colorectal cancer in high-risk patients.  I consider the findings of this clinical study to be of very high significance, and it should, in my opinion, compel a new randomized, placebo-controlled, double-blinded prospective study to validate these extremely impressive and encouraging findings.

 

Although favorable data supporting aspirin as a powerful cancer prevention agent continues to accumulate, the regular use of aspirin can be associated with serious, and even life-threatening, side effects, including ulcers of the GI tract, GI tract bleeding, kidney injury, and allergic reactions, among others.  Therefore, if you are thinking of adding aspirin to your list of medications, then I urge you to first discuss this with your doctor!

 

A Cancer Prevention Guide for the Human Race is now available in both printed and digital formats from all major bookstores.  Get your copy now, and begin living an evidence-based cancer prevention lifestyle now!

 

Please be sure to check out Dr. Wascher’s latest music video:

Dark as Night, Part 1

 


Dark as Night, Part 1

Dark as Night, Part 1


At this time, more than 8 percent of Americans are unemployed.  According to the Bureau of Labor Statistics, however, the unemployment rate for veterans who served on active duty between September 2001 and December 2011 is now more than 12 percent.  A new website, Veterans in Healthcare, seeks to connect veterans with potential employers.  If you are a veteran who works in the healthcare field, or if you are an employer who is looking for physicians, advanced practice professionals, nurses, corpsmen/medics, or other healthcare professionals, then please take a look at Veterans in Healthcare. As a retired veteran of the U.S. Army, I would also like to personally urge you to hire a veteran whenever possible.


For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my bestselling book, “A Cancer Prevention Guide for the Human Race,” from AmazonBarnes & NobleBooks-A-MillionVroman’s Bookstore, and other fine bookstores!

Within one week of publication, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books. Within three months of publication, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list.




Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


 

Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


 

I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people from around the world who visit this premier global health information website every month.  (More than 1.3 million pages of high-quality medical research findings were served to the worldwide audience of health-conscious people who visited Weekly Health Update in 2011!)  As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.


 






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Aspirin Cuts Cancer Risk and Cancer Death Rates





A new study shows that aspirin not only reduces the risk of getting cancer, but may also reduce death rates in patients with cancer.


 

ASPIRIN CUTS CANCER RISK AND CANCER DEATH RATES

As I discuss in my bestselling book, A Cancer Prevention Guide for the Human Race, aspirin may be able to do much more than just relieve a headache, or reduce the risk of heart disease.  Indeed, a growing body of scientific evidence strongly suggests that aspirin may also significantly reduce the risk of developing cancer.  Now, a newly published research study, which appears in the current issue of the Lancet Oncology journal, suggests that aspirin may not only reduce the risk of developing certain cancers, but may also reduce the risk of cancer spread in patients who have already been diagnosed with cancer, as well.

An important and unique aspect of this particular study is that it reviewed the results from numerous previous aspirin studies, including both highly powered prospective randomized clinical research studies and lower powered public health studies.

Based upon this massive review study, the regular use of aspirin was associated with a 38 percent reduction in the risk of developing colorectal cancer, and a 42 percent reduction in the risk of death due to colorectal cancer.  Similar reductions in the risk of other major cancer killers were also observed with regular aspirin use, including cancers of the esophagus, stomach, bile ducts, liver and breast.

Among patients already diagnosed with cancer, regular aspirin use was associated with a 31 percent decrease in the incidence of distant spread of cancer.  (This is an important finding, as most patients who die from cancer do so due to the distant spread, or metastasis, of their cancer rather than due to the presence of their original, or primary, tumor alone.)

The findings of this important study are highly significant, as they lend further important evidence that the humble aspirin tablet can significantly reduce our risk of developing many of the most prolific cancer killers of mankind.  Moreover, regular aspirin use may also reduce the risk of distant spread (metastasis) for many types of cancer, which may, in turn, reduce the risk of death associated with these cancers.

As aspirin use can be associated with serious side effects, including GI tract ulcers, bleeding, kidney injury, and other potentially serious health complications, I recommend that patients first talk with their doctor before starting daily aspirin therapy.


For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my bestselling book, “A Cancer Prevention Guide for the Human Race,” from AmazonBarnes & NobleBooks-A-MillionVroman’s Bookstore, and other fine bookstores!

Within one week of publication, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books. Within three months of publication, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list.


Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


For a lighthearted perspective on Dr. Wascher, please click on the following YouTube link:

Texas Blues Jam


I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people from around the world who visit this premier global health information website every month.  (More than 1.3 million pages of high-quality medical research findings were served to the worldwide audience of health-conscious people who visited Weekly Health Update in 2011!)  As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.


 



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Aspirin May Help to Prevent Breast Cancer

Welcome to Weekly Health Update



A large meta-analysis suggests that aspirin may lower a woman’s risk of developing breast cancer.



ASPIRIN MAY HELP TO PREVENT BREAST CANCER

As I have discussed in my bestselling book, A Cancer Prevention Guide for the Human Race, aspirin may have an important potential role in the prevention of certain types of cancer, including colorectal cancer and pancreatic cancer.  However, the available research data on aspirin as a breast cancer prevention medication has been rather mixed, to date.

A new meta-analysis study, which appears in the current issue of the journal Breast Cancer Research & Treatment, adds weight to previous studies suggesting a potential role for aspirin in the prevention of breast cancer.  In this meta-analysis, the results of 33 different clinical research studies were analyzed.  Altogether, nearly two million research volunteers participated in these 33 studies.  When considering the results of these 33 different research studies, the authors of this meta-analysis determined that the regular use of aspirin was associated with an average 14 percent reduction in the risk of developing breast cancer.

While this meta-analysis study showed an overall trend towards a decreased risk of developing breast cancer in women who regularly took aspirin, there is one very important caveat that I must emphasize.  Only one of the 33 research studies that were analyzed in this meta-analysis was a prospective, randomized, placebo-controlled study (i.e., the type of clinical research study that provides the highest level of scientific and clinical findings), and it was this study, alone among the 33 different clinical studies, that did not find any breast cancer prevention benefit associated with regular aspirin use.

While all but one of the 33 clinical research studies in this meta-analysis identified a significant reduction in breast cancer risk in women who regularly took aspirin, the failure of the lone prospective, randomized, placebo-controlled clinical research trial to confirm this finding means that additional prospective, randomized, placebo-controlled research studies will need to be performed before aspirin can be definitively recommended as a breast cancer prevention medication.

As I have stressed before, all medications, including aspirin, can be associated with potentially serious side effects.  Therefore, if you are considering aspirin therapy, for the prevention of heart disease or cancer, then it is very important for you to check with your doctor before you begin taking aspirin.

 

For a comprehensive guide to living an evidence-based cancer prevention lifestyle, order your copy of my new book, A Cancer Prevention Guide for the Human Race.  For the price of a cheeseburger, fries, and a shake, you can purchase this landmark new book, in both paperback and e-book formats, and begin living an evidence-based cancer prevention lifestyle today!


For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, “A Cancer Prevention Guide for the Human Race,” from AmazonBarnes & NobleBooks-A-Million,Vroman’s Bookstore, and other fine bookstores!

On Thanksgiving Day, 2010, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books! On Christmas Day, 2010, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list!


Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


For a different perspective on Dr. Wascher, please click on the following YouTube link:

Texas Blues Jam


I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month. (More than 1.2 million health-conscious people visited Weekly Health Update in 2010!) As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.


 



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Aspirin May Reduce the Risk of Deadly Pancreatic Cancer

Welcome to Weekly Health Update



New research shows that aspirin may significantly reduce the risk of pancreatic cancer, one of the deadliest of all cancers.



 

ASPIRIN MAY REDUCE THE RISK OF DEADLY PANCREATIC CANCER

The recent tragic death of Steve Jobs, of Apple fame, due to a rare form of pancreatic cancer has once again focused public attention on one of the deadliest forms of cancer. The more common form of pancreatic cancer, pancreatic ductal cancer, is only the tenth most common form of cancer, but because it is such a lethal disease, pancreatic cancer is actually the fourth most common cause of cancer-related death. Sadly, only about 5 percent of people diagnosed with pancreatic cancer will still be alive 5 years later.

In my book, A Cancer Prevention Guide for the Human Race, I extensively discuss the available research findings that can help to lower your risk of pancreatic cancer, and other deadly forms of cancer. (Also, please see my recent report on pancreatic cancer prevention on Newsmax.) Now, a newly published clinical research study suggests that aspirin, which has also been shown to reduce the risk of colorectal cancer, may also significantly reduce the risk of developing pancreatic cancer.

This new research study appears in the journal Cancer Prevention Research. This clinical research study was performed at the Mayo Clinic, and included 904 patients recently diagnosed with pancreatic cancer and 1,224 healthy age-matched and gender-matched “control” patients. In this case-control study, the impact of aspirin intake was analyzed in both groups of patients.

In this study, the use of aspirin at least one day per month was associated with a very significant 26 percent reduction in the risk of developing pancreatic cancer. Among patients who took low-dose aspirin (81 mg per day) every day for heart disease prevention, the risk of pancreatic cancer was reduced by 33 percent.

The findings of this important study suggest that the humble aspirin tablet may significantly reduce the risk of developing what is arguably the most lethal of all cancers (in addition to reducing the risk of colorectal cancer and, potentially, other cancers as well). As I discuss in A Cancer Prevention Guide for the Human Race, even a relatively modest reduction in the risk of the deadliest types of cancer can be an important achievement, because our therapies for these kinds of cancer, including pancreatic cancer, so rarely result in a cure. While this case-control study is not as statistically powerful as a prospective, randomized, placebo-controlled clinical research study, prior laboratory and clinical research studies have also shown that aspirin can reduce pancreatic cancer cell growth. The findings of these previous studies, therefore, generally support the findings of this new Mayo Clinic study suggesting that aspirin may, indeed, reduce the risk of developing pancreatic cancer.

I must caution readers that aspirin, like all medications, can be associated with significant side effects. In the case of aspirin, specifically, GI tract irritation can cause abdominal pain, nausea, vomiting, and even GI tract bleeding. Aspirin can also increase the risk of bleeding in other areas of the body, and can be toxic to the kidneys in some patients as well. Therefore, if you are considering the addition of low-dose aspirin to your cancer prevention lifestyle, you should first check with your personal physician to ensure that it is safe for you to do so.



For a comprehensive guide to living an evidence-based cancer prevention lifestyle, order your copy of my new book, A Cancer Prevention Guide for the Human Race.  For the price of a cheeseburger, fries, and a shake, you can purchase this landmark new book, in both paperback and e-book formats, and begin living an evidence-based cancer prevention lifestyle today!

For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, A Cancer Prevention Guide for the Human Race,” from Amazon, Barnes & Noble, Books-A-Million,Vroman’s Bookstore, and other fine bookstores!

On Thanksgiving Day, 2010, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books! On Christmas Day, 2010, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list!


Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


For a different perspective on Dr. Wascher, please click on the following YouTube link:

Texas Blues Jam


I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month. (More than 1.2 million health-conscious people visited Weekly Health Update in 2010!) As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.


 



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Aspirin May Prevent Pancreatic Cancer

Welcome to Weekly Health Update


“A critical weekly review of important new research findings for health-conscious readers”



 

ASPIRIN MAY PREVENT PANCREATIC CANCER

Pancreatic cancer is a relatively rare form of cancer (fewer than two percent of adults in the United States will ever be diagnosed with this form of cancer). However, although rare, pancreatic cancer is an extremely lethal type of cancer, with an average 5-year survival rate of only 5 to 8 percent, overall. Therefore, as I discuss extensively in my recent book, A Cancer Prevention Guide for the Human Race, any cancer prevention strategy that even modestly decreases the risk of this terrible form of cancer should be carefully considered.

Aspirin belongs to a class of medications known as non-steroidal anti-inflammatory drugs (NSAIDs). Aspirin, like other NSAIDs, blocks a key enzyme that leads to inflammation in our bodies. This enzyme, cyclooxygenase, is also known to play an important role in the development of several types of cancer, and so aspirin, and other NSAIDs, have been extensively studied as potential cancer prevention drugs.

A new pancreatic cancer prevention study from the prestigious Mayo Clinic appears in the current issue of the journal Cancer Prevention Research. In this clinical study, 904 patients with known pancreatic cancer were compared with 1,224 healthy “control” patients with the same age and sex distribution as the group of patients with pancreatic cancer. The frequency and dose of aspirin intake was then evaluated for both groups of patients.

In this clinical research study, the use of aspirin one or more days per month was associated with 26 percent decrease in the risk of developing pancreatic cancer. Among patients who took low-dose aspirin each day to prevent heart disease, the protective effect against pancreatic cancer appeared to be even greater, with an observed 33 percent decrease in the risk of developing pancreatic cancer in this sub-group of patients.

While a randomized, placebo-controlled, prospective clinical research trial will be necessary to confirm the encouraging findings of this clinical research study, the findings of this “case control” study are, nonetheless, very compelling. Moreover, the findings of this retrospective study are very similar to the findings of both retrospective and prospective clinical research studies that have previously identified a similar reduction in the risk of colorectal cancer with aspirin and other NSAIDs.

As aspirin can cause significant adverse health effects, including GI tract ulcers, GI tract bleeding, and kidney damage, aspirin therapy should only started with the approval of your physician.

 

For my previous columns on aspirin as a cancer prevention drug, please click the following links:

Low Dose Aspirin Reduces Colorectal Cancer Risk

Aspirin & Breast Cancer Survival

Aspirin & Colorectal Cancer Prevention; Fish Oil & Respiratory Infections in Children

 


For a comprehensive guide to living an evidence-based cancer prevention lifestyle, order your copy of my new book, A Cancer Prevention Guide for the Human Race.  For the price of a cheeseburger, fries, and a shake, you can purchase this landmark new book, in both paperback and e-book formats, and begin living an evidence-based cancer prevention lifestyle today!

For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, A Cancer Prevention Guide for the Human Race,” from Amazon, Barnes & Noble, Books-A-Million,Vroman’s Bookstore, and other fine bookstores!

On Thanksgiving Day, 2010, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books! On Christmas Day, 2010, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list!


Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author

 



For a different perspective on Dr. Wascher, please click on the following YouTube link:

Texas Blues Jam


I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month. (More than 1.2 million health-conscious people visited Weekly Health Update in 2010!) As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.





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Low Dose Aspirin Reduces Colorectal Cancer Risk

 

Welcome to Weekly Health Update



“A critical weekly review of important new research findings for health-conscious readers”



LOW DOSE ASPIRIN REDUCES COLORECTAL CANCER RISK

Colorectal cancer is the third most common cause of cancer-associated death in the United States (and in many other countries around the world).  Diet, obesity, and other lifestyle factors are known to play a significant role in colorectal cancer risk, as I discuss in detail in my new book, A Cancer Prevention Guide for the Human Race. 

Nonsteroidal anti-inflammatory drugs (NSAIDs), including aspirin, have been shown to reduce the risk of colorectal cancer.  Unfortunately, the majority of non-aspirin NSAIDs have been shown to increase the risk of cardiovascular disease, and so these drugs are seldom used, today, for colorectal cancer prevention.  (In most cases, their use for this purpose has become largely restricted to patients with inherited gene mutations that place them at extremely high risk for developing colorectal cancer.)

While high daily doses of aspirin have been shown to reduce the risk of colorectal cancer, this form of cancer prevention therapy also has significant risks, including serious GI tract bleeding and kidney damage.  Until very recently, there has been very little high quality research data available regarding the effectiveness of low-dose aspirin therapy on colorectal cancer risk.  Now, a newly published study in the prestigious journal, The Lancet, indicates that low-dose aspirin therapy can, indeed, significantly reduce the risk of colorectal cancer.

This report actually combines the long-term results from four large prospective, randomized, placebo-controlled clinical research studies (the Swedish Aspirin Low Dose Trial, UK-TIA Aspirin Trial, the Thrombosis Prevention Trial, and the British Doctors Aspirin Trial).  Altogether, a whopping 14,033 patient volunteers were studied in these research trials, and the average duration of patient follow-up was a very impressive 18.3 years.

Overall, the use of 75 milligrams (mg) of aspirin per day, for 5 years or longer, dramatically reduced the risk of cancer in the upper colon, by about 70 percent.  While the incidence of lower colon cancer was not significantly reduced by low-dose aspirin therapy, the risk of rectal cancer was reduced by a very significant 42 percent.  Moreover, increased daily doses of aspirin (above 75 mg) did not result in any further decrease in the risk of colon cancer or rectal cancer.

The findings of this very large clinical research study represent a very significant breakthrough in our understanding of the role of aspirin in colorectal cancer prevention and, especially, in the optimization of daily aspirin dosing to maximize this drug’s cancer prevention benefit while simultaneously reducing the known (and sometimes serious) adverse side effects of chronic aspirin therapy.

As always, I must remind readers that they should first consult with their doctor prior to beginning aspirin therapy, as some health conditions may be associated with an increased risk of severe side effects when taking aspirin.

 

 

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Disclaimer: As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


 

Dr. Wascher is an oncologic surgeon, a professor of surgery, a cancer researcher, an oncology consultant, and a widely published author


 

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I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month.  (As of 9/16/2010, more than 1,000,000 health-conscious people have logged onto Weekly Health Update so far this year!)  As always, I enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.


 

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Aspirin & Breast Cancer Survival

March 28, 2010 by Robert Wascher  
Filed under Weekly Health Update

 

Welcome to Weekly Health Update



“A critical weekly review of important new research findings for health-conscious readers” 


ASPIRIN & BREAST CANCER SURVIVAL

 

Breast cancer tumors, like many other types of cancer, produce increased amounts of chemicals called prostaglandins.  As with many other types of cancer, prostaglandins are thought to play an important role in the growth and spread of breast cancer. 

Aspirin belongs to a class of drugs known as NSAIDs (non-steroidal anti-inflammatory drugs).  Like other NSAIDs, aspirin is able to block the activity of the prostaglandin-producing enzyme cyclooxygenase (COX).  Moreover, previous research has indicated that, in addition to decreasing prostaglandin production in the body, aspirin also reduces the levels of estrogen in the body (approximately 90 percent of breast cancers are stimulated to grow in the presence of estrogen).

Previous research on aspirin as a breast cancer prevention drug has resulted in contradictory findings (although aspirin and other NSAIDs have clearly been shown to reduce the incidence of colorectal polyps and colorectal cancer, and other cancers as well).  However, a newly published study, in the Journal of Clinical Oncology, adds weight to prior evidence that the regular intake of aspirin may significantly decrease the risk of breast cancer recurrence, and the risk of death due to recurrent breast cancer.

The enormous Nurses’ Health Study is a prospective public health research study that began in 1976 with more than 120,000 female nurses in the United States.  Every 2 years, this huge cohort of women completes detailed personal questionnaires regarding diet and lifestyle factors related to cardiovascular disease and cancer.  Between 1976 and 2002, more than 4,000 nurses participating in this study were newly diagnosed with breast cancer.  The researchers conducting this landmark study then analyzed the incidence of breast cancer recurrence, and the risk of death, among these 4,164 breast cancer patients as a function of their aspirin intake.  (Other cancer-associated diet and lifestyle risk factors were also analyzed, as well.)

In this huge prospective public health trial, regular aspirin intake was found to significantly reduce the risk of death due to breast cancer.  Taking aspirin 2 to 5 times per week was associated with a 71 percent reduction in the relative risk of death due to breast cancer, while 6 to 7 days of aspirin use per week was associated with a 64 percent reduction in the relative risk of cancer-associated death.  Importantly, this apparent aspirin-associated reduction in the risk of death due to breast cancer recurrence was observed in women with both early-stage and more advanced breast cancers, in both premenopausal and postmenopausal women, in both obese and non-obese women, and in women with estrogen-sensitive and estrogen-resistant tumors. 

While this study’s primary weakness is that (like most epidemiological studies) the collected data was primarily based upon patient questionnaires, the Nurses’ Health Study continues to be a carefully conducted prospective study with very stringent data quality controls in place.   

To summarize the important findings of this study:  Among women previously diagnosed with breast cancer, taking aspirin for 2 or more days per week was associated with a significant reduction in the risk of both breast cancer recurrence and death due to breast cancer.  (As always, I recommend that you discuss the potential risks and benefits of regularly taking aspirin, or any other new medication, with your doctor before making such changes.)

 

To learn more about the potential role of NSAIDs in cancer risk reduction, look for the publication of my new landmark book, “A Cancer Prevention Guide for the Human Race,” in the spring/summer of this year.


Disclaimer: As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, a professor of surgery, a cancer researcher, an oncology consultant, and a widely published author



For a different perspective on Dr. Wascher, please click on the following YouTube link: 

http://www.youtube.com/watch?v=7-Tdv7XW0qg



I and the staff of Weekly Health Update would like to take this opportunity to thank the nearly 120,000 new and returning readers who visited our premier global health information website last month.  As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can. 



In view of the extreme devastation and human misery brought about in Haiti and Chile by the recent earthquakes, Weekly Health Update asks our tens of thousands of caring readers to give generously to established charities that are currently working in those countries to assist the injured, the ill, and the homeless.  There are many such legitimate charities, including the following two:

http://www.redcross.org/

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