Yoga Improves Chronic Fatigue in Breast Cancer Survivors

January 2, 2012 by admin  
Filed under Breast Cancer, Cancer, Yoga, chemotherapy, fatigue

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YOGA IMPROVES CHRONIC FATIGUE IN BREAST CANCER SURVIVORS

Breast cancer remains the most common serious cancer to afflict women, and the second most common cause of cancer-related death in women (second only to lung cancer).  In 2012, most patients with breast cancer will undergo surgery, chemotherapy, radiation therapy, and hormonal therapy as standard treatments for their cancer, and as many as 1 in 3 breast cancer survivors will go on to experience chronic fatigue after completing their extensive therapy for this common disease.

Many interventions have been proposed for chronic post-treatment fatigue in breast cancer survivors, but none of these interventions have been subjected to the scrutiny of high quality, prospective, randomized, controlled clinical research studies to validate their effectiveness.  However, a newly published prospective, randomized, controlled clinical research study suggests that lyengar yoga may be an effective intervention for chronic fatigue following breast cancer treatment.  This new study appears in the current issue of the journal Cancer.

Thirty-one female breast cancer survivors with chronic fatigue were randomized to one of two groups in this study.  Sixteen of these women were randomized to a yoga instruction group for 12 weeks (the “experimental” group), while the other 15 women were randomized to 12 weeks of health education classes (the “control” group).  At the end of the 12-week study period, and again 3 months later, the two groups of women were assessed for changes in fatigue levels (compared to baseline, at the time of their entry into the study); as well as changes in vigor, depressive symptoms, sleep quality, perceived stress levels, and physical performance status.

Following analysis of the data, the authors of this study concluded that 12 weeks of yoga training significantly improved the severity of chronic post-treatment fatigue in breast cancer survivors, when compared to 12 weeks of health education instruction.  (Importantly, this improvement in fatigue levels was maintained for at least 3 months after completion of 12 weeks of yoga classes.)  Additionally, the yoga group experienced significant improvements in physical vigor, when compared to the health education group of women.  At the same time, both groups of women reported improvements in depressive symptoms and perceived stress at the end of this clinical study, while no significant improvements in sleep quality or physical performance status were noted in either group of study participants.

This study is the first prospective, randomized, controlled clinical research study to show that a 12-week intervention with yoga training leads to significant and sustained improvements in chronic fatigue and physical vigor among women who have completed multidisciplinary therapy for breast cancer.  Based upon the findings of this small but important clinical study, breast cancer survivors who are struggling with post-treatment chronic fatigue might want to check out a yoga studio in their neighborhood!


For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, “A Cancer Prevention Guide for the Human Race,” from AmazonBarnes & NobleBooks-A-MillionVroman’s Bookstore, and other fine bookstores!

On Thanksgiving Day, 2010, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books! On Christmas Day, 2010, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list!


Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


For a different perspective on Dr. Wascher, please click on the following YouTube link:

Texas Blues Jam


I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people from around the world who visit this premier global health information website every month.  (More than 1.3 million pages of high-quality medical research findings were served to the worldwide audience of health-conscious people who visited Weekly Health Update in 2011!)  As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.


 




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Aspirin May Help to Prevent Breast Cancer

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A large meta-analysis suggests that aspirin may lower a woman’s risk of developing breast cancer.



ASPIRIN MAY HELP TO PREVENT BREAST CANCER

As I have discussed in my bestselling book, A Cancer Prevention Guide for the Human Race, aspirin may have an important potential role in the prevention of certain types of cancer, including colorectal cancer and pancreatic cancer.  However, the available research data on aspirin as a breast cancer prevention medication has been rather mixed, to date.

A new meta-analysis study, which appears in the current issue of the journal Breast Cancer Research & Treatment, adds weight to previous studies suggesting a potential role for aspirin in the prevention of breast cancer.  In this meta-analysis, the results of 33 different clinical research studies were analyzed.  Altogether, nearly two million research volunteers participated in these 33 studies.  When considering the results of these 33 different research studies, the authors of this meta-analysis determined that the regular use of aspirin was associated with an average 14 percent reduction in the risk of developing breast cancer.

While this meta-analysis study showed an overall trend towards a decreased risk of developing breast cancer in women who regularly took aspirin, there is one very important caveat that I must emphasize.  Only one of the 33 research studies that were analyzed in this meta-analysis was a prospective, randomized, placebo-controlled study (i.e., the type of clinical research study that provides the highest level of scientific and clinical findings), and it was this study, alone among the 33 different clinical studies, that did not find any breast cancer prevention benefit associated with regular aspirin use.

While all but one of the 33 clinical research studies in this meta-analysis identified a significant reduction in breast cancer risk in women who regularly took aspirin, the failure of the lone prospective, randomized, placebo-controlled clinical research trial to confirm this finding means that additional prospective, randomized, placebo-controlled research studies will need to be performed before aspirin can be definitively recommended as a breast cancer prevention medication.

As I have stressed before, all medications, including aspirin, can be associated with potentially serious side effects.  Therefore, if you are considering aspirin therapy, for the prevention of heart disease or cancer, then it is very important for you to check with your doctor before you begin taking aspirin.

 

For a comprehensive guide to living an evidence-based cancer prevention lifestyle, order your copy of my new book, A Cancer Prevention Guide for the Human Race.  For the price of a cheeseburger, fries, and a shake, you can purchase this landmark new book, in both paperback and e-book formats, and begin living an evidence-based cancer prevention lifestyle today!


For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, “A Cancer Prevention Guide for the Human Race,” from AmazonBarnes & NobleBooks-A-Million,Vroman’s Bookstore, and other fine bookstores!

On Thanksgiving Day, 2010, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books! On Christmas Day, 2010, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list!


Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


For a different perspective on Dr. Wascher, please click on the following YouTube link:

Texas Blues Jam


I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month. (More than 1.2 million health-conscious people visited Weekly Health Update in 2010!) As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.


 



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Clonidine and the Antidepressant Effexor Both Reduce Hot Flashes

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The blood pressure medication clonidine and the antidepressant venlafaxine (Effexor) both reduce hot flashes caused by breast cancer treatment and by menopause.




CLONIDINE AND THE ANTIDEPRESSANT EFFEXOR BOTH REDUCE HOT FLASHES

 

The modern management of breast cancer often includes “hormonal therapy,” in which medications that block the effects of estrogen, or decrease the amount of estrogen manufactured by the body, are used to reduce the risk of breast cancer recurrence.  Despite significantly lowering the risk of breast cancer recurrence in patients with estrogen-sensitive breast tumors, recent clinical research studies have shown that fewer than one-half of all breast cancer patients actually go on to complete the recommended 5-year course of hormonal therapy.  (This very poor level of compliance with a medical therapy proven to lower recurrence and death rates associated with breast cancer is particularly an issue among younger women.)

While there are several reasons why more than half of all breast cancer patients do not complete their recommended course of hormonal therapy, one of the major causes, and especially among younger patients, is that these medications are commonly associated with significant side effects, including the same hot flashes that frequently accompany menopause.

Numerous treatment interventions have been tried in an effort prevent hot flashes associated with breast cancer therapy (as well as hot flashes in postmenopausal women without breast cancer), but very few of these therapies have been shown to have any clinically significant benefit. However, several previous clinical studies have suggested that certain types of antidepressant medications, as well as the blood pressure medication clonidine, may reduce the severity and frequency of hot flashes. Unfortunately, much of the research in this area has been of rather low quality, and so the findings of these lower level studies have not radically changed the way that most physicians have managed their patients’ hot flashes. Now, a newly published prospective, randomized, placebo-controlled, blinded clinical research study, which appears in the current issue of the Journal of Clinical Oncology, strongly suggests that venlafaxine (also known by its trade name, Effexor®), a medication that is part of the new “serotonin–norepinephrine reuptake inhibitors” (SNRIs) class of antidepressants, and clonidine may both be effective in decreasing the severity and frequency of hot flashes in women with a history of breast cancer.

In this study, 102 women with a history of both breast cancer and severe hot flashes were secretly and randomly assigned to take either venlafaxine (75 mg per day), clonidine (0.1 mg per day), or an identical-appearing placebo (sugar) pill. Following 12 weeks of observation, 80 patients remained in this clinical study. At the end of this 12-week clinical study, both clonidine and venlafaxine were found to significantly decrease the severity and frequency of hot flashes, when compared to placebo pills. Although both medications were clinically effective in reducing hot flashes, and although venlafaxine resulted in a more rapid reduction in hot flashes than clonidine, clonidine was associated with a greater overall improvement in hot flashes, when compared to venlafaxine, after 12 weeks of treatment. (Venlafaxine was also associated with a greater incidence of nausea, constipation, and appetite loss, compared to clonidine.)

The findings of this study add to those of prior studies that have shown a 15 to 25% reduction in the severity and frequency of hot flashes with antidepressants such as venlafaxine, and with clonidine. Moreover, prior studies have shown that these two medications reduce the severity and frequency of hot flashes in women with a history of breast cancer as well as in postmenopausal women without a prior history of breast cancer.

One important limitation of this study is its small size, and its high patient drop-out rate, which resulted in small numbers of patient volunteers in each of the three “arms” of this prospective, randomized, blinded, placebo-controlled study.  However, the findings of this small clinical research study, nonetheless, are still consistent with those of previously published studies; and taken together, these studies suggest that venlafaxine (and other modern antidepressant medications) and clonidine may be effective in reducing the severity and frequency of hot flashes in both breast cancer patients who are undergoing hormonal therapy for their cancer and in postmenopausal women with menopause-associated hot flashes.


 

For a comprehensive guide to living an evidence-based cancer prevention lifestyle, order your copy of my new book, A Cancer Prevention Guide for the Human Race.  For the price of a cheeseburger, fries, and a shake, you can purchase this landmark new book, in both paperback and e-book formats, and begin living an evidence-based cancer prevention lifestyle today!


For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, A Cancer Prevention Guide for the Human Race,” from Amazon, Barnes & Noble, Books-A-Million,Vroman’s Bookstore, and other fine bookstores!

On Thanksgiving Day, 2010, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books! On Christmas Day, 2010, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list!


Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


For a different perspective on Dr. Wascher, please click on the following YouTube link:

Texas Blues Jam


I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month. (More than 1.2 million health-conscious people visited Weekly Health Update in 2010!) As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.


 



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Vitamin D May Significantly Decrease Breast Cancer Risk

Welcome to Weekly Health Update


A new research study suggests that breast cancer risk can be cut in half with adequate Vitamin D levels in the blood.



VITAMIN D MAY SIGNIFICANTLY DECREASE BREAST CANCER RISK

As I discuss in detail in my recent book, A Cancer Prevention Guide for the Human Race, there is considerable research evidence linking low Vitamin D levels in the blood with a higher risk of some types of cancer, and colorectal cancer in particular.As I have discussed previously in this column, there is also some research evidence available to suggest that low levels of Vitamin D may, similarly, be associated with an increased risk of breast cancer, as well as a possible increase in the risk of recurrence of prior breast cancers (although the results of still other studies have not supported these conclusions). Now, a new analysis of recent breast cancer prevention research studies suggests that higher levels of Vitamin D in the blood may indeedsignificantly decrease the risk of developing breast cancer.

Meta-analysis studies use powerful statistical formulas to combine the results of multiple smaller research studies into a single larger and more conclusive “meta-study.” This form of statistical analysis is especially useful for evaluating clinical research studies that have utilized different research methods to arrive at their final conclusions. A new meta-analysis of 11 previously published breast cancer risk research studies has just been published, and this new comprehensive meta-analysis appears in the current issue of the journal Anticancer Research.

Following meta-analysis of the results of 11 different breast cancer risk studies, this new study determined that high-normal levels of Vitamin D in the blood were associated with a significantly lower risk of developing breast cancer when compared to low Vitamin D levels. Indeed, in this meta-analysis, a Vitamin D level of 47 ng/ml in the blood was associated with a whopping50 percent reduction in breast cancer risk, when compared to women who had very low blood levels of this hormone-like vitamin.(While there is no uniform agreement on “normal” blood levels of Vitamin D, most experts recommend that Vitamin D levels be maintained in the 30 to 50 ng/ml range.)

While increased Vitamin D intake has been repeatedly linked with a lower risk of some cancers, as well as a decreased risk of heart disease, excessive Vitamin D levels in the blood can cause serious illnesses, including kidney failure, calcium deposits throughout the body, gastrointestinal ulcers, and other serious health problems. Therefore, prior to beginning Vitamin D supplementation (or, indeed, before starting any new supplement or medication), please consult with your personal physician first!


For a comprehensive guide to living an evidence-based cancer prevention lifestyle, order your copy of my new book, A Cancer Prevention Guide for the Human Race.  For the price of a cheeseburger, fries, and a shake, you can purchase this landmark new book, in both paperback and e-book formats, and begin living an evidence-based cancer prevention lifestyle today!

For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, A Cancer Prevention Guide for the Human Race,” from Amazon, Barnes & Noble, Books-A-Million,Vroman’s Bookstore, and other fine bookstores!

On Thanksgiving Day, 2010, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books! On Christmas Day, 2010, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list!


Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


For a different perspective on Dr. Wascher, please click on the following YouTube link:

Texas Blues Jam


I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month. (More than 1.2 million health-conscious people visited Weekly Health Update in 2010!) As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.




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Breast Cancer Cells in the Blood Predict High Risk of Recurrence

Welcome to Weekly Health Update


“A critical weekly review of important new research findings for health-conscious readers”



 

BREAST CANCER CELLS IN THE BLOOD PREDICT HIGH RISK OF RECURRENCE

During my time in the lab, as a research fellow at the John Wayne Cancer Institute, I completed several research studies that revealed a powerful link between the presence of tiny numbers of cancer cells floating in the blood and overall survival in patients without any evidence of recurrent cancer by standard laboratory and radiographic tests.  In these research studies, we used a powerful test, reverse transcriptase-polymerase chain reaction (RT-PCR) to detect fragments of genetic material from otherwise undetectable cancer cells in the blood of patients with a prior history of cancer.  (RT-PCR, which can detect the presence of a single tumor cell floating amongst more than a million normal blood cells, is a powerful tool for detecting trace numbers of cancer cells present in the blood, bone marrow, lymph nodes, and other tissues of the body.)

A newly published RT-PCR research study appears in the current issue of the British Journal of Cancer. In this study, the blood of 82 early-stage breast cancer patients was tested for occult breast cancer cells using RT-PCR. Additionally, 16 patients with advanced breast cancer and 45 patient volunteers without breast cancer were used as “control groups.” All of these patient volunteers were then followed for an average of 51 months.

Among the women with very early breast cancer, 20 percent were found to have occult breast cancer cells lurking in their blood. By comparison, 81 percent of the women with late-stage breast cancer were found to have breast cancer cells circulating in their blood. (None of the healthy volunteers were found to have genetic evidence of circulating breast cancer cells in their blood.)

In this study, as with the findings of my own research in this area, the presence of rare circulating cancer cells in the blood of even patients with early-stage breast cancer was a powerful predictor of future breast cancer recurrence. Among these early-stage breast cancer patients, a positive RT-PCR test of the blood was associated with more than 5 times the risk of breast cancer recurrence (a more than 500 percent increase in recurrence risk) when compared to the early-stage breast cancer patients who did not have any detectable tumor cells circulating in their blood.

As with my own research, and the research of other cancer scientists, this newly published breast cancer research study confirms that the presence of trace numbers of cancer cells in the blood, even in patients with very early breast cancer, is highly predictive of future breast cancer recurrence. This is an important finding, and for several reasons. First of all, the detection of even tiny numbers of circulating tumor cells in the blood of early-stage breast cancer patients indicates a much worse prognosis for such patients, even when all of our standard laboratory and x-ray tests do not reveal any evidence of persistent or recurrent cancer in these same patients. Secondly, “ultra-staging” cancer patients with RT-PCR may be able to help us to identify early-stage cancer patients who might benefit from more aggressive treatment than patients who have no detectable tumor cells circulating in their blood.

Based upon the findings of this study, and those of other similar research studies (including my own), RT-PCR has the potential to become a very powerful clinical tool to help us to more accurately stage patients with early-stage cancers, and to individualize and personalize cancer treatment based upon this so-called “molecular” approach to cancer diagnosis and treatment.




For a comprehensive guide to living an evidence-based cancer prevention lifestyle, order your copy of my new book, A Cancer Prevention Guide for the Human Race.  For the price of a cheeseburger, fries, and a shake, you can purchase this landmark new book, in both paperback and e-book formats, and begin living an evidence-based cancer prevention lifestyle today!

For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, A Cancer Prevention Guide for the Human Race,” from Amazon, Barnes & Noble, Books-A-Million,Vroman’s Bookstore, and other fine bookstores!

On Thanksgiving Day, 2010, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books! On Christmas Day, 2010, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list!


Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity



Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author



For a different perspective on Dr. Wascher, please click on the following YouTube link:

Texas Blues Jam



I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month. (More than 1.2 million health-conscious people visited Weekly Health Update in 2010!) As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.





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Axillary Lymph Node Dissection for Breast Cancer May Not Be Necessary

Welcome to Weekly Health Update


“A critical weekly review of important new research findings for health-conscious readers”



AXILLARY LYMPH NODE DISSECTION FOR BREAST CANCER MAY NOT BE NECESSARY

The management of breast cancer has undergone many advances since the radical mastectomy that first came into popularity in the United States in the late 19th century.  At that time, even early cancers of the breast were managed by surgically removing the entire breast, the underlying chest wall muscles, and all of the lymph nodes under the armpit (axilla).  It wasn’t until the 1970s that surgeons began to abandon radical mastectomy, in favor of the less disfiguring modified radical mastectomy, based upon emerging research data at the time.  By the 1980s, additional research data had confirmed that women who underwent lumpectomy plus radiation therapy experienced equivalent survival when compared to women who underwent mastectomy.  In the late 1990s, another major paradigm shift in the surgical management of breast cancer occurred with the rapid adoption of sentinel lymph node (SLN) biopsy, which had previously also revolutionized the surgical management of melanoma.  Following the successful application of SLN biopsy to breast cancer, the 60 to 70 percent of women with breast cancer who have normal axillary SLNs (i.e., no evidence of spread of breast cancer cells to the lymph nodes in the axilla) could now avoid undergoing complete axillary lymph node dissection (ALND), wherein about two-thirds of the armpit lymph nodes are surgically removed.  As the risk of arm swelling (lymphedema), numbness, and other long-term side effects associated with ALND are only one-tenth as common following SLN biopsy, the majority of women undergoing breast cancer surgery over the past decade have been able to avoid many of the chronic complications and side effects associated with the more radical surgical approaches used in the past.  However, between one-fourth and one-third of women diagnosed with breast cancer will still be found to have tumor cell in their SLNs, and most of these women have routinely been advised to undergo ALND to remove additional armpit lymph nodes.

Now, a newly published clinical research study from the American College of Surgeons Oncology Group has, once again, dramatically shifted the paradigm of breast cancer management.  This clinical research study, which I was privileged to participate in when I was a Surgical Oncology Fellow at the John Wayne Cancer Institute, enrolled 891 women newly diagnosed with breast cancer, and with early metastatic cancer involving one or more of their axillary SLNs.  These women were evenly randomized into two groups.  One group underwent the standard therapy of ALND, while the other half of these patient volunteers were observed, without further surgery, following SLN biopsy.  The results of this pioneering breast cancer research study appear in the current issue of the Journal of the American Medical Association.

After an average duration of patient follow-up of more than 6 years, this pivotal clinical study has confirmed what many of us oncologists have long suspected.  In women with evidence of microscopic spread of breast cancer to one or more axillary SLNs, there was no difference in overall survival whether or not they went on to undergo ALND, as long as they underwent otherwise standard therapy for lymph-node-positive breast cancer (including lumpectomy, radiation therapy to the breast, and chemotherapy).

I cannot overstate the potential impact of the findings of this important clinical study.  However, while some have heralded the findings of this study as breaking important new ground, in fact that ground was broken by the very same pioneering prospective clinical research study (the National Surgical Adjuvant Breast and Bowel Project’s NSABP B-04 study, which began in 1971) that originally led surgeons to abandon radical mastectomy.  Within this older large prospective clinical study was an important subgroup of 586 women with palpably enlarged axillary lymph nodes (and which actually indicated a more advanced stage of lymph node involvement than the women who participated in the more modern American College of Surgeons Oncology Group study).  Like all of the women who participated in the NSABP B-04 study, these 586 breast cancer patients with enlarged armpit lymph nodes were randomized to undergo radical mastectomy with radical ALND versus mastectomy alone (and no lymph node surgery at all ) combined with radiation therapy.  After an average follow-up of 25 years, there wasabsolutely no difference in survival between the women who underwent radical lymph node surgery combined with radical mastectomy versus those women who underwent simple mastectomy alone (and no lymph node surgery) followed by radiation therapy.

Thus, the newly reported findings of this pivotal American College of Surgeons Oncology Group clinical study only further validates the findings of the nearly 40 year-old NSABP B-04 study, and should put to rest, once and for all, the decades-old debate about the role of surgery in the management of the axillary lymph nodes in patients with newly diagnosed breast cancer.  At a minimum, surgeons should now advise their breast cancer patients that there is now 40 years worth of high-level clinical research data showing that the surgical removal of most or all of the armpit lymph nodes (ALND) does not improve survival in women who otherwise undergo standard breast cancer treatment that includes lumpectomy (or mastectomy), chemotherapy, and radiation therapy.

I predict that the findings of these two landmark breast cancer surgical studies will, together, once again revolutionize the surgical management of breast cancer, and will further reduce the adverse impact of surgery on hundreds of thousands of women around the world each year.  Indeed, this latest revolution in the management of breast cancer has already started at major cancer centers in the United States, where women are already being advised that the finding of early spread of breast cancer cells to their axillary SLNs no longer mandates “completion ALND,” as long as these patients undergo standard chemotherapy and radiation therapy following lumpectomy and SLN biopsy.


For a complete discussion of evidence-based approaches to cancer risk and cancer prevention, order your copy of my new book, A Cancer Prevention Guide for the Human Race.  For the price of a cheeseburger, fries, and a shake, you can purchase this landmark new book, in both paperback and e-book formats, and begin living an evidence-based cancer prevention lifestyle today!


For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, “A Cancer Prevention Guide for the Human Race,” from AmazonBarnes & NobleBooks-A-MillionVroman’s Bookstore, and other fine bookstores!


On Thanksgiving Day, 2010, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books! On Christmas Day, 2010, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list!



Disclaimer: As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity




Dr. Wascher is an oncologic surgeon, a professor of surgery, a cancer researcher, an oncology consultant, and a widely published author




For a different perspective on Dr. Wascher, please click on the following YouTube link: Texas Blues Jam



I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month. (More than 1.2 million health-conscious people visited Weekly Health Update in 2010!) As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.







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Obesity, Diabetes and Breast Cancer Recurrence Risk

 

Welcome to Weekly Health Update


“A critical weekly review of important new research findings for health-conscious readers”


OBESITY, DIABETES AND BREAST CANCER RECURRENCE RISK

 

Obesity and diabetes have both been linked to an increased risk of certain types of cancer (including breast cancer), as discussed in detail in my new book, A Cancer Prevention Guide for the Human Race.  (The single greatest risk factor for adult-onset diabetes is obesity.)

Not only have obesity and diabetes been strongly linked to an increased risk of developing cancer, but these two chronic illnesses, which have become epidemic in our modern culture, also appear to increase the risk of breast cancer recurrence, and death due to recurrent breast cancer.  Two newly published clinical research studies, which appear in the current issue of the Journal of Clinical Oncology, reveal just how strongly obesity and diabetes impact the incidence of breast cancer recurrence, and death due to breast cancer, among women who have previously been diagnosed with this common form of cancer.

In the first study, the impact of obesity on breast cancer recurrence, and the risk of death due to breast cancer, was assessed among 18,967 women with a previous diagnosis of breast cancer in Denmark.   Using body mass index (BMI) scores, which indicate whether a person is obese or not, the findings of this study were quite concerning.  (A BMI between 18.5 and 24.9 indicates a healthy weight, while a BMI of 25 to 29.9 indicates that a person is overweight, and a BMI of 30 or more indicates obesity.)

In this very large public health study with long-term follow-up, female breast cancer survivors with a BMI of 30 or more (when compared to women with a BMI below 25) were, stage-for-stage, 46 percent more likely to be diagnosed with metastatic breast cancer within 10 years of their original diagnosis, and 38 percent more likely to die of metastatic breast cancer within 30 years of their original breast cancer diagnosis.

In the second study, 604 women with a prior diagnosis of breast cancer were evaluated with a blood test that measures insulin secretion levels (serum C-peptide).  Fasting C-peptide levels were measured in these breast cancer survivors 3 years after their initial cancer diagnosis, and this group of research volunteers was then followed for about a decade.  In this study, a 1nanogram per milliliter (ng/mL) increase in serum C-peptide levels, even among women without diabetes, was associated with a 31 percent increase in the risk of death from any cause over the duration of this study.  This same miniscule 1 ng/mL increase in C-peptide blood levels was also associated with a 35 percent increase in the risk of death specifically due to breast cancer.  (The increased risk of death associated with rising C-peptide levels among women with diabetes was even higher.)  Thus, this study is one of the first ever to show that rising levels of insulin secretion in women either with or without diabetes is associated with a significantly higher risk of death due to recurrent breast cancer.

Taken together, the findings of these two very important clinical studies add to the findings of previous studies that have linked both obesity and diabetes with an increased likelihood of breast cancer recurrence and death due to recurrent breast cancer.  These, and other, clinical studies also continue to show that the chemotherapy and hormonal therapy that is routinely given following the diagnosis of breast cancer appears to be less effective in obese women and in diabetic women, when compared to women without either of these chronic illnesses.  The findings of these studies also mirror cancer risk and cancer prevention studies that have linked breast cancer risk with both obesity and diabetes.

If you have a history of breast cancer, and you are significantly overweight, then it is essential that you discuss a prudent weight loss program with your doctor, including a healthy diet and a regimen of regular aerobic exercise (as discussed in my new book).  Likewise, if you have diabetes, both weight loss interventions and tight control of your diabetes are essential for reducing your risk of breast cancer recurrence, and your overall risk of premature death from cancer and other serious illnesses associated with diabetes.

 

For a complete discussion of the role of obesity, diabetes, diet, and exercise in cancer prevention, and other important evidence-based approaches to cancer prevention, order your copy of my new book, A Cancer Prevention Guide for the Human Race, now!  For the price of a cheeseburger, fries, and a shake, you can purchase this landmark new book, in both paperback and e-book formats, and begin living an evidence-based cancer prevention lifestyle today!

 

GIVE  THE  GIFT  OF  HEALTH  THIS  HOLIDAY  SEASON!  For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, A Cancer Prevention Guide for the Human Race,” from Amazon, Barnes & Noble, Books-A-Million, Vroman’s Bookstore, and other fine bookstores! 

 

On Thanksgiving Day, 2010, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.comTop 100 Bestseller’s List” for Kindle e-books!  On Christmas Day, 2010, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list!



Disclaimer: As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, a professor of surgery, a cancer researcher, an oncology consultant, and a widely published author


For a different perspective on Dr. Wascher, please click on the following YouTube link: 

Texas Blues Jam



I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month.  (As of 9/16/2010, more than 1,000,000 health-conscious people had logged onto Weekly Health Update in 2010!)  As always, I enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.




Click the following link to join Dr. Wascher on Facebook





 

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Mammograms Save Lives in Women with Family History of Breast Cancer

 

Welcome to Weekly Health Update



“A critical weekly review of important new research findings for health-conscious readers”




MAMMOGRAMS SAVE LIVES IN WOMEN WITH

FAMILY HISTORY OF BREAST CANCER

 

While the debate about whether or not routine screening mammograms can save lives continues in some circles, the clinical research evidence supporting mammograms as a lifesaving cancer screening exam continues to accumulate.  Now, a newly published public health study, which appears in The Lancet Oncology, examines the survival benefit associated with routine screening mammograms in women who have a family history of breast cancer.

In this large multicenter prospective clinical research study, which was performed in the UK, 6,710 women between the ages of 40 and 42 were enrolled in this study, and were followed for an average of about 4 years.  These women, who had at least some family history of breast cancer, underwent annual screening mammograms as part of this clinical research study.  This study used two important control groups to assess the impact of regular annual screening mammograms on the risk of mortality in these young women.  The first control group consisted of women who were at average risk for breast cancer (these women, themselves, served as the control group for the enormous UK Age Trial, which included more than 106,000 patient volunteers, and which recently reported a 10-year follow-up of its results).  The second control group, against which these 6,710 women with an intermediate familial risk of breast cancer were compared, included young women from another large public health study that was performed in the Netherlands.

Among the 136 women who were diagnosed with breast cancer during the relatively brief course of this ongoing study, 77 percent were diagnosed by screening mammography, while 21 percent were diagnosed when they presented with a new breast lump (or with other clinical signs or symptoms of breast cancer).  (Another 2 percent of patients failed to attend their scheduled screening mammograms, and subsequently developed clinical signs or symptoms of breast cancer.)

In this study (and as other studies have shown, even among women who are at average risk of developing breast cancer), breast cancers that were detected by annual screening mammograms were significantly smaller in size, and significantly less likely to be associated with the spread of cancer to the lymph nodes.  In addition to these very important breast cancer prognostic factors, women who were diagnosed with breast cancer as a result of annual screening mammograms had much less aggressive appearing tumors under the microscope when compared to women who were diagnosed with breast cancer only after a lump, or other signs of breast cancer, appeared.

Based upon the findings of this newly published study, young women with even an intermediate risk of breast cancer, based upon having one or more relatives with breast cancer, were 20 percent less likely to die within 10 years when compared with a poorly screened, or unscreened, average-risk population of young women.  Moreover, this survival advantage appeared to be directly related to annual screening mammograms, once all other breast cancer risk factors among these three populations of women had been considered.

 

For a complete discussion of the compelling scientific evidence linking routine screening mammograms with a decreased risk of death due to breast cancer, please see the extended clinical section on breast cancer in my new book, A Cancer Prevention Guide for the Human Race.

  

Click the following link to join Dr. Wascher on Facebook


GIVE THE GIFT OF HEALTH THIS HOLIDAY SEASON!  For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, A Cancer Prevention Guide for the Human Race,” from Amazon, Barnes & Noble, Books-A-Million, Vroman’s Bookstore, and other fine bookstores! 

On Thanksgiving Day, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com Top 100 Bestseller’s List for Kindle e-books!



Disclaimer: As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


 

Dr. Wascher is an oncologic surgeon, a professor of surgery, a cancer researcher, an oncology consultant, and a widely published author


 

For a different perspective on Dr. Wascher, please click on the following YouTube link: 

Texas Blues Jam


 

I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month.  (As of 9/16/2010, more than 1,000,000 health-conscious people have logged onto Weekly Health Update so far this year!)  As always, I enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.


 

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Hormone Replacement Therapy (HRT) and Breast Cancer Risk

 

Welcome to Weekly Health Update



“A critical weekly review of important new research findings for health-conscious readers”



pink-ribbon-image

   

 

OCTOBER IS NATIONAL BREAST CANCER

 

AWARENESS MONTH

 

 

 

HORMONE REPLACEMENT THERAPY (HRT)

AND BREAST CANCER RISK

The rising incidence of breast cancer, year-after-year, over the past 50 years in the United States (and in many other industrialized countries) has been attributed to a variety of factors, including environmental contaminants, rising obesity levels, and increased compliance with annual screening mammograms, among others.  However, one factor that has been given inadequate attention, in my view, is that of hormone replacement therapy (HRT), despite nearly a century of data showing a strong linkage between lifetime exposure to the female hormones estrogen and progesterone and the risk of developing breast cancer.

In 2002, the enormous, randomized, prospective, blinded Women’s Health Initiative (WHI) study published its preliminary results, and prematurely terminated its combination HRT study because of an alarming increase in the incidence of breast cancer in the group of women who had been secretly randomized to receive combination HRT medications for menopausal symptoms.

Despite subsequent updates from the WHI, which have shown, essentially, a doubling of breast cancer risk after more than 5 years of HRT use, there was initially a great deal of resistance to the WHI’s findings (and the findings of other similar clinical research trials) linking HRT use with an increased risk of developing breast cancer.

Now, a new national Canadian public health study offers additional powerful clinical research data linking HRT use with breast cancer risk, and reveals the equally strong link between declining HRT use and the declining breast cancer incidence in Canada.  This study appears in the current issue of the Journal of the National Cancer Institute.

In this study, 1,200 women between the ages of 50 and 69 participated in the National Population Health Survey between 1996 and 2006.  Just prior to the 2002 release of the WHI study’s results, 13 percent of these women regularly used combination HRT.  By December 2004, only 5 percent of the postmenopausal women participating in this study were still taking HRT medications.  During this same period, the incidence of breast cancer in this large group of Canadian women decreased by about 10 percent.  (Importantly, compliances rates with screening mammograms did not change during the course of this clinical research study.)

Thus, between 2002 and 2004, when HRT use significantly declined, the incidence of breast cancer decreased by about 10 percent in Canada.  Moreover, this significant decrease in breast cancer incidence occurred without any change in mammogram rates.

This study, as with other recent studies, adds to the overwhelming research data linking HRT use with an increased risk of developing breast cancer.  As I tell my own patients who are approaching menopause, it is best to avoid HRT altogether.  If you are already taking HRT medications, then ask your doctor to help you in weaning yourself off of these medications.

 

In recognition of Breast Cancer Awareness Month, I urge our tens of thousands of regular Weekly Health Update readers to join in the global fight against breast cancer.  There are numerous organizations and groups, in virtually every community, that are sponsoring fundraising activities throughout October, including the Susan G. Komen Race for the Cure.  Another opportunity to participate (and at no cost!) is to vote for the Dr. Susan Love Research Foundation Army of Women project in the Pepsi Refresh competition!  There are also many other worthwhile and deserving fundraising programs available for everyone to become involved in! 

 

For a deeper evidence-based discussion of the links between HRT and breast cancer risk, order your copy of my new book, A Cancer Prevention Guide for the Human Race,” from Amazon, Barnes & Noble, Books-A-Million, Vroman’s Bookstore, and other fine bookstores!


 


 

Disclaimer: As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity




Dr. Wascher is an oncologic surgeon, a professor of surgery, a cancer researcher, an oncology consultant, and a widely published author




For a different perspective on Dr. Wascher, please click on the following YouTube link: 

Texas Blues Jam



I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month.  (As of 9/16/2010, more than 1,000,000 health-conscious people have logged onto Weekly Health Update so far this year!)  As always, I enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.



 

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Mammograms Between 40 and 49 Years of Age

 

Welcome to Weekly Health Update



“A critical weekly review of important new research findings for health-conscious readers”


pink-ribbon-image

   

 

OCTOBER IS NATIONAL BREAST CANCER

 

AWARENESS MONTH

 

 

 

MAMMOGRAMS BETWEEN 40 AND 49 YEARS OF AGE

Both patients and their physicians were stunned last year when the U.S. Department of Health and Human Services’ U.S. Preventive Services Task Force (USPSTF) recommended against routine annual screening mammograms in women between the age of40 and 49 years (as has been the standard recommendation in the United States, and in most countries around the world, for many years).  The USPSTF’s recommendations quickly set off a firestorm of debate regarding the calculations and public health considerations used by the USPSTF to arrive at this surprising recommendation.  Since the USPSTF released its recommendations in the fall of 2009, most breast cancer specialists and breast cancer advocacy groups have continued to recommend that women who are at average risk of developing breast cancer begin routine annual screening mammograms at age 40. 

As I extensively discuss in my new book, A Cancer Prevention Guide for the Human Race, there is ample available clinical research data showing that screening mammograms detect breast cancer at an earlier stage than other commonly available screening methods, and that survival is improved in women in whom breast cancer is first detected by a mammogram (as opposed to the detection of a palpable or visible breast mass).

Now, a newly published large-scale public health study from Sweden, which appears in the current issue of the journal Cancer, offers further important evidence that the routine use of annual screening mammograms among women between 40 and 49 years of age significantly reduces the risk of dying from breast cancer.

In this enormous study, women between the ages of 40 and 49 years were separated into two groups, depending upon whether or not they underwent annual screening mammograms between 1986 and 2005 (the average duration of patient follow-up in this study was a very impressive 16 years).  In this very powerful research study, young women who underwent annual mammograms accounted for 7.3 million “person-years” of observation, while the young women who did not undergo mammograms accounted for a similarly astonishing 8.8 million “person-years” of observation within this landmark public health study. 

When the number of breast cancer deaths were assessed in both of these huge groups of young women, the women who underwent routine annual mammograms were found to be 29 percent less likely to die of breast cancer when compared to the young women who did not undergo annual mammograms!  (In public health terms, this 29 percent observed reduction in the death rate due to breast cancer is highly clinically significant!)

 

This public health study, which encompassed the entire country of Sweden, is the largest mammography study of its kind, and its findings are both powerful and persuasive in defense of beginning routine annual screening mammograms at the age of 40 in women who are at average risk of developing breast cancer.  It is my hope that the dramatic findings of this huge clinical study will now lay to rest any lingering doubts regarding the effectiveness of screening mammograms, beginning at 40 years of age, in reducing the risk of death due to breast cancer.

 

 

In recognition of Breast Cancer Awareness Month, I urge our tens of thousands of regular Weekly Health Update readers to join in the global fight against breast cancer.  There are numerous organizations and groups, in virtually every community, that are sponsoring fundraising activities throughout October, including the Susan G. Komen Race for the Cure.  Another opportunity to participate (and at no cost!) is to vote for the Dr. Susan Love Research Foundation Army of Women project in the Pepsi Refresh competition!  There are also many other worthwhile and deserving fundraising programs available for everyone to become involved in! 

 

For an evidence-based discussion of the critical importance of breast cancer screening, including mammograms, in a cancer prevention lifestyle, order your copy of my new landmark book, “A Cancer Prevention Guide for the Human Race,” from Amazon or Barnes & Noble, Books-A-Million, Vroman’s Bookstore, and other fine bookstores! 


 


 

Disclaimer: As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity



Dr. Wascher is an oncologic surgeon, a professor of surgery, a cancer researcher, an oncology consultant, and a widely published author



For a different perspective on Dr. Wascher, please click on the following YouTube link: 

Texas Blues Jam


I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month.  (As of 9/16/2010, more than 1,000,000 health-conscious people have logged onto Weekly Health Update so far this year!)  As always, I enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.



 

Bookmark and Share



 

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