The Four Critical Cardiovascular Disease Risks That You Can Change

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New research shows that high blood pressure, high cholesterol, diabetes, and smoking account for the vast majority of all deaths caused by cardiovascular disease.


 

THE FOUR CRITICAL CARDIOVASCULAR DISEASE RISKS THAT YOU CAN CHANGE

As I mention in my recent bestselling book, A Cancer Prevention Guide for the Human Race, many of the very same lifestyle and dietary habits that increase our risk of developing cancer also increase our risk of developing cardiovascular disease, including coronary artery disease, heart attacks (myocardial infarction), peripheral vascular disease, and stroke.  Likewise, adopting an evidence-based cancer prevention lifestyle can not only cut your cancer risk in half, but can also significantly reduce your risk of developing life-threatening cardiovascular disease as well.

A newly published research study, which was funded by the National Institutes of Health, provides, for the first time, a comprehensive assessment of the lifetime risks of developing cardiovascular disease based upon the following four health-related factors: blood pressure, cholesterol (lipid) levels in the blood, smoking status, and diabetes status.  Importantly, this huge meta-analysis study, which appears in the current issue of the New England Journal of Medicine, comprehensively analyzes the data from 18 different prior clinical research studies, which included 257,384 adult black and white men and women.  These research volunteers were assessed for these four critical cardiovascular risk factors every 10 years, beginning at age 45 and ending at age 75.  This enormous group of research volunteers was then closely followed, and the incidence of cardiovascular disease and death rates due to cardiovascular disease were then carefully evaluated and analyzed.

When looking at cardiovascular risks factors at age 55 as predictors of future cardiovascular disease risk, and the risk of death due to cardiovascular disease, the findings of this extremely large clinical study were striking.  In this study, a low-risk profile for cardiovascular disease was defined as total blood cholesterol less than 180 milligrams per deciliter (4.7 mmol per liter), average blood pressure less than 120/80 millimeters of mercury (mm Hg), nonsmoker status, and nondiabetic status.

Among the 55 year-old men and women who met all of the criteria for a low-risk profile for cardiovascular disease, their lifetime incidence of cardiovascular disease, through age 80, was remarkably lower than for the 55 year-olds who failed to meet two or more of the four low-risk criteria.  In fact, the risk of death due to cardiovascular disease, through age 80, was only 5 percent among the men who met all four low-risk criteria at age 55, while the men who met only two or fewer low-risk criteria faced a dramatic six-fold increase in the risk (30 percent) of dying of cardiovascular disease by age 80.  Among the women volunteers, only 6 percent of the women who met all four low-risk criteria went on to die of cardiovascular disease by age 80, while 21 percent of the women who failed to meet two or more of the four low-risk criteria died of cardiovascular disease between age 55 and age 80 (for a nearly four-fold increase in the risk of death).

Fatal and nonfatal coronary artery disease occurred in only 4 percent of the men who met all four low-risk criteria, but occurred in nearly 10 times as many of the men (38 percent) who failed to meet two or more of these four criteria.  The women who met all four low-risk criteria faced a less than 1 percent risk of fatal and nonfatal coronary artery disease, while the women who met two or fewer low-risk criteria experienced an 18 percent incidence of fatal and nonfatal coronary artery disease (for a more than 18-fold increase in risk).

The risk of fatal and nonfatal stroke was also significantly lower among men and women who met all four low-risk criteria for cardiovascular disease.  Among the men who met all four low-risk criteria, the incidence of stroke through age 80 was only about 2 percent, but quadrupled, to more than 8 percent, among the men who failed to meet two or more of the four low-risk criteria.  Among the women who met all four low-risk criteria, the incidence of stroke was about 5 percent, but more than doubled, to nearly 11 percent, among the women who failed to meet at least two of the low-risk criteria.

The findings of this very large study cannot be overstated in terms of its public health importance, as this is the only study that has prospectively assessed very large numbers of men and women, including both black and white adults, over long periods of time, and that has analyzed the long-term impact of the four most common risk factors for cardiovascular disease on incidence and death rates associated with cardiovascular disease.  As with the studies that I discuss in A Cancer Prevention Guide for the Human Race, the impact of lifestyle, diet, and other modifiable health-related factors on both cardiovascular disease risk and cancer risk is enormous, particularly when measured over the lifespan of the average adult.

The findings of this epic public health research study also add further weight to my strong belief, based upon my review of thousands of research studies, that we, as individuals, hold the key to improving our health, and to significantly reducing our risk of serious illness and premature death, by living evidence-based healthy lifestyles.  If your blood pressure is high, change your diet and increase your level of exercise, with the support of your doctor.  If diet and physical activity interventions alone do not correct your hypertension, then ask your doctor about medications for high blood pressure.  If you have diabetes, you also need to change your diet, increase your levels of physical activity, and safely lose any excess weight.  If these lifestyle changes do not completely resolve your high blood sugars, then you may also need to ask your doctor about medications for diabetes.  If you smoke, or use smokeless tobacco, stop immediately.  Finally, if your LDL and total cholesterol levels are high, then, once again, you need to be more careful about what you eat.  (The cancer-preventing foods and diets that I discuss in my book have also been linked to lower levels of blood cholesterol, as well as a much lower risk of cardiovascular disease.)  You may also need to increase your physical activity levels, and get your weight down to a healthy level, to improve your LDL and total cholesterol levels.  Once again, if these prudent lifestyle measures are not enough, by themselves, to bring your cholesterol levels down into the normal range, then your doctor may need to add a cholesterol-lowering medication as well.

The striking results of this important cardiovascular disease prevention study provide all of us with the key to maximally reducing our risk of developing—and dying from—largely preventable cardiovascular diseases, including heart disease and stroke.  Better long-term health (and a longer and more vigorous life) is within your grasp, and this study, in addition to my book, can show you the way forward.


For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, “A Cancer Prevention Guide for the Human Race,” from AmazonBarnes & NobleBooks-A-MillionVroman’s Bookstore, and other fine bookstores!

On Thanksgiving Day, 2010, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books! On Christmas Day, 2010, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list!



Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


For a different perspective on Dr. Wascher, please click on the following YouTube link:

Texas Blues Jam


I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people from around the world who visit this premier global health information website every month.  (More than 1.3 million pages of high-quality medical research findings were served to the worldwide audience of health-conscious people who visited Weekly Health Update in 2011!)  As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.


 








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Effective New Treatment for Chronic Pain

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New research shows that behavioral therapy combined with an exercise program may be the most effective treatment for chronic pain.


 

 

EFFECTIVE NEW TREATMENT FOR CHRONIC PAIN

According to the American Academy of Pain Medicine, chronic pain afflicts nearly 1 out of every 3 American men, women and children, and is associated with an estimated cost to society of $560 to $635 billion per year.  While there are many causes of chronic pain, they all share a common trait in that almost all types of chronic pain are associated with significant physical and psychological disability in afflicted patients.

Unlike acute pain (like the pain that follows a fresh cut on your hand, or spraining your ankle, for example), which subsides very quickly, chronic pain usually does not improve on its own.  Moreover, while you may hop around and shout out a few choice words after smashing your thumb with a hammer, the acute pain caused by a poorly aimed hammer usually does not leave a person feeling depressed or completely disabled like chronic pain so often does.  Over time, as chronic pain persists, the area in the brain (the limbic system) that attaches emotional content or value to our experiences and sensations becomes increasingly involved with interpreting the chronic barrage of pain sensations from damaged nerves or chronic inflammation, which leaves many chronic pain sufferers debilitated, and often depressed.  Because of the biological complexity of chronic pain, when compared to acute pain, it can be very difficult to effectively treat this lingering form of pain.  Patients suffering with chronic pain frequently find their symptoms both physically and emotionally disabling, and medications commonly used to treat acute pain are often ineffective in managing chronic pain.  As I have noted, depression is a common feature of chronic pain, and often requires treatment with antidepressant medications and behavioral therapy in addition to treating the original cause (or causes) of a patient’s pain.

Now, a newly published prospective randomized clinical research study offers new hope for the estimated 116 million Americans who suffer from chronic pain.  This study, which appears in the current issue of the Archives of Internal Medicine, randomized 442 patients with chronic pain to receive one of the following interventions for a period of 6 months:  (1) telephone-based behavioral therapy, (2) a graded, step-wise exercise program, (3) a combination of both telephone-based therapy and a graded exercise program, or (4) standard treatment for chronic pain.  All of the study volunteers were assessed at the time that they entered into the study, 6 months later, and again at 9 months.

The results of this innovative study were quite interesting.  Following 6 months of standard chronic pain management, only 8 percent of the study volunteers randomized to this intervention group noticed any significant improvement in their symptoms, and this result was unchanged 9 months after the start of this clinical study.  Among the patients who underwent 6 months of telephone-based behavior therapy, 33 percent felt that their chronic pain was improved at 9 months.  After 6 months of treatment, 35 percent of the patients who participated in a graduated exercise program felt improved, although this effect decreased over time, with 24 percent of this group of patients reporting improvement in their chronic pain symptoms at 9 months.  Finally, the combined therapy group (behavioral therapy and exercise) experienced the greatest improvement in their symptoms, compared to the other treatment groups, with 37 percent of patients in this group reporting significant improvement at both 6 months and 9 months.

This study represents an extremely important advance in the management of chronic pain, a condition that is highly resistant to most conventional therapies and medications.  As a cancer physician who regularly treats cancer patients with chronic pain, I am not surprised by the extremely poor response of patients to conventional chronic pain management approaches in this study.  While the 37 percent positive response rate noted in this study to combination therapy may seem like a rather poor result, chronic pain syndromes are so difficult to effectively treat that this study’s 37 percent response rate is actually extremely impressive.  Based upon the results of this important study, behavioral therapy combined with exercise therapy appears to be the most effective and long-lasting treatment approach for patients with chronic pain.  At the same time, the dismal response rate associated with standard chronic pain management approaches, as noted in this study, should cause pain management specialists to seriously reevaluate current methods of treating patients with chronic pain.


For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, “A Cancer Prevention Guide for the Human Race,” from AmazonBarnes & NobleBooks-A-MillionVroman’s Bookstore, and other fine bookstores!

On Thanksgiving Day, 2010, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books! On Christmas Day, 2010, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list!


Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity



Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author



For a different perspective on Dr. Wascher, please click on the following YouTube link:

Texas Blues Jam



I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people from around the world who visit this premier global health information website every month.  (More than 1.3 million pages of high-quality medical research findings were served to the worldwide audience of health-conscious people who visited Weekly Health Update in 2011!)  As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.


 





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Lifestyle and Diet Modifications Reduce Erectile Dysfunction (ED)

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New research suggests that the same lifestyle and diet choices that reduce cardiovascular disease risk also reduce the risk of erectile dysfunction (ED) in men, and improve male sexual function.



LIFESTYLE AND DIET MODIFICATIONS REDUCE ERECTILE DYSFUNCTION (ED)

As I discuss in my book, A Cancer Prevention Guide for the Human Race, evidence-based lifestyle and diet modifications can dramatically reduce your lifetime risk of developing cancer, including some of the most deadly forms of this disease.  As an “added benefit,” many of the same lifestyle and diet modifications that I discuss in my book have also been shown to reduce the risk of cardiovascular disease, as well.  Moreover, previous research studies have suggested that the risk of male sexual dysfunction, and erectile dysfunction (ED) in particular, might also be reduced by living a heart-healthy lifestyle.

The most important risk factors for sexual dysfunction in men, and ED in particular, include heart disease, peripheral vascular disease, elevated blood cholesterol, high blood pressure, diabetes, smoking, obesity, and sedentary behavior. Since the risk of these serious health problems can all be significantly reduced through lifestyle and diet modification, it is worth asking whether or not evidence-based lifestyle modifications associated with a reduced risk of cardiovascular disease and diabetes can also significantly reduce the risk of ED. A newly published research study, which appears in the current issue of the Archives of Internal Medicine, provides important new insights into this serious men’s health issue.

In a meta-analysis of 6 previously published prospective randomized clinical research studies, 740 adult male research study volunteers were evaluated. In this group of men, heart-healthy changes in diet, physical activity, and other modifiable lifestyle factors were associated with a highly significant improvement in sexual function when compared to similar-aged men who did not modify their lifestyle and diet. (Moreover, the addition of cholesterol-lowering statin drugs in men with elevated blood cholesterol levels improved sexual function even further than lifestyle and diet modifications, alone.)

Too many men continue to refuse to change their unhealthy lifestyles and dietary habits, and so they face an increased risk of cardiovascular disease, obesity, diabetes, high blood pressure, and other largely preventable diseases.  However, sexual function is such a very important quality-of-life factor for most men that it is my hope that studies such as this one will get the attention of men who are still living unhealthy lifestyles that increase their risk of ED and other preventable serious illnesses.  Also, as ED is now known to be an early warning sign of cardiovascular disease, diabetes, and other preventable lifestyle-associated diseases in men, modifying your lifestyle and diet to reduce your risk of ED will also significantly reduce your risk of these other life-threatening diseases at the same time (and cancer, as well)!


For a comprehensive guide to living an evidence-based cancer prevention lifestyle, order your copy of my new book, A Cancer Prevention Guide for the Human Race.  For the price of a cheeseburger, fries, and a shake, you can purchase this landmark new book, in both paperback and e-book formats, and begin living an evidence-based cancer prevention lifestyle today!

For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, A Cancer Prevention Guide for the Human Race,” from Amazon, Barnes & Noble, Books-A-Million,Vroman’s Bookstore, and other fine bookstores!

On Thanksgiving Day, 2010, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books! On Christmas Day, 2010, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list!


Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


For a different perspective on Dr. Wascher, please click on the following YouTube link:

Texas Blues Jam


I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month. (More than 1.2 million health-conscious people visited Weekly Health Update in 2010!) As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.





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Ginger May Prevent Prostate Cancer

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New research suggests that ginger root extract may have potent activity against prostate cancer and other types of cancer.



 

GINGER MAY PREVENT PROSTATE CANCER

As I discuss in my book, A Cancer Prevention Guide for the Human Race, there is a growing body of research evidence demonstrating potent cancer properties associated with certain foods and nutrients. While much of the available research in support of specific dietary and other lifestyle-related approaches to cancer prevention is of low scientific quality, more recent cancer prevention research studies have provided higher levels of scientific and clinical evidence in support of an evidence-based approach to a cancer prevention lifestyle.

A newly published research study, which appears in the current issue of the British Journal of Nutrition, suggests that ginger root may possess clinically important cancer prevention activity. (Previous research studies have also shown that ginger extracts are capable of reducing cancer cell growth in laboratory settings, and are associated with antioxidant and anti-inflammatory effects as well.)

In this particular research study, human prostate cancer cells were transplanted into laboratory mice. In the group of mice that received daily ginger extract dietary supplements (100 milligrams of ginger extract per kilogram of body weight), the growth of these transplanted prostate cancer tumors was reduced by a rather impressive 56 percent when compared to the mice that did not receive ginger extract. When the transplanted prostate cancer tumors were removed from the mice and further studied, the researchers found that the tumors in the mice that had received ginger extract displayed extensive cancer cell death (as compared to the tumors taken from the mice that did not receive ginger extract). Importantly, there was no evidence of side effects noted among the mice that received the ginger extract supplements in this study.

The findings of this laboratory research study, when combined with the findings of previous research studies, suggest that ginger may have significant anti-cancer properties. These high-quality laboratory studies have identified multiple biochemical mechanisms whereby ginger appears to significantly impair cancer cell growth and reproduction, and increase cancer cell death through a biological process known as apoptosis.

While the findings of this laboratory research study are highly intriguing, I must caution readers that what works in laboratory mice with a genetically engineered faulty immune system does not always turn out to work in humans. Therefore, a prospective, randomized, placebo-controlled clinical research trial will be necessary to determine whether or not ginger supplements can actually reduce prostate cancer risk (and the risk of other cancers) in humans, or slow down the progression of cancer in patients who have already been diagnosed with prostate cancer or other cancers. At the same time, ginger has been used for thousands of years, and most research studies indicate no apparent toxicity in humans after consuming doses of ginger far greater than the dose that was utilized in this particular laboratory study. (As always, however, I strongly recommend that readers first check with their personal physician before adding any new supplements to their diet.)


 

For a comprehensive guide to living an evidence-based cancer prevention lifestyle, order your copy of my new book, A Cancer Prevention Guide for the Human Race.  For the price of a cheeseburger, fries, and a shake, you can purchase this landmark new book, in both paperback and e-book formats, and begin living an evidence-based cancer prevention lifestyle today!

For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, A Cancer Prevention Guide for the Human Race,” from Amazon, Barnes & Noble, Books-A-Million,Vroman’s Bookstore, and other fine bookstores!

On Thanksgiving Day, 2010, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books! On Christmas Day, 2010, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list!


Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity



Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author



For a different perspective on Dr. Wascher, please click on the following YouTube link:

Texas Blues Jam



I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month. (More than 1.2 million health-conscious people visited Weekly Health Update in 2010!) As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.





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Lifestyle, Diet and Diabetes Risk

Welcome to Weekly Health Update


New research reveals the profound impact of diet, obesity, and lifestyle factors on diabetes risk.



 

 

LIFESTYLE, DIET AND DIABETES RISK

Along with the incidence of obesity, the incidence of diabetes has recently skyrocketed in the United States and around the world.  The list of health complications associated with diabetes is frightening, and includes heart disease, peripheral vascular disease, stroke, kidney failure, progressive blindness, and as I discuss in my book, A Cancer Prevention Guide for the Human Race, an increased risk of cancer.

Now, a newly published clinical research study, which included more than 200,000 adult volunteers, sheds important light on the major lifestyle-associated risk factors for this life-threatening disease.  Nearly 2 million adults will be newly diagnosed with diabetes this year in the United States, and nearly 80 million Americans are currently living with diabetes at this time. In fact, diabetes has become such a serious public health problem that it is now considered the seventh leading cause of death in the United States!

This newly published prospective public health study appears in the current issue of the Annals of Internal Medicine, and was sponsored by the National Heart, Lung, and Blood Institute and the National Cancer Institute, as part of the National Institutes of Health-AARP Diet and Health Study.

A total of 114, 996 men and 92,483 women, aged 50 to 71 years, participated in this public health study; and this huge group of research volunteers was closely followed for an average of 10 years. Importantly, none of these research volunteers had diabetes, heart disease, or cancer at the time they initially joined this research study.

After evaluating diet, level of physical activity, smoking status, and alcohol intake, this enormous group of research volunteers was assessed for the risk of onset of diabetes according to these lifestyle factors. Altogether, about 10 percent of the men and 8 percent of the women went on to develop diabetes during the 10-year course of this public health study. When compared to men who ate poorly and did not exercise, and who also smoked and regularly consumed alcohol, the men who had very healthy behaviors in these same areas had a 39 percent lower risk of developing diabetes, while the women with healthy lifestyle behaviors experienced a 57 percent lower risk of diabetes when compared to the women with unhealthy lifestyle behaviors. Even more impressive was the additive role of obesity on diabetes risk. When all of the previously mentioned healthy lifestyle behaviors were combined with the absence of being overweight or obese, men experienced a whopping 72 percent decrease in the risk of diabetes, while women experienced an extraordinary 84 percent reduction in the risk of developing diabetes. Importantly, these dramatic reductions in the risk of diabetes were maintained even among the men and women who had a family history of diabetes or obesity.

This huge prospective public health study adds important and helpful information to our understanding regarding the most important risk factors for diabetes, and reveals just how important eating a healthy diet, maintaining a healthy weight, getting regular exercise, abstaining from tobacco use, and minimizing alcohol intake are to the prevention of diabetes.  Other large public health studies have also conclusively linked these healthy lifestyle-associated behaviors with a significant reduction in the risk of cardiovascular disease (including heart disease, peripheral vascular disease, and stroke) and cancer, as well!




For a comprehensive guide to living an evidence-based cancer prevention lifestyle, order your copy of my new book, A Cancer Prevention Guide for the Human Race.  For the price of a cheeseburger, fries, and a shake, you can purchase this landmark new book, in both paperback and e-book formats, and begin living an evidence-based cancer prevention lifestyle today!

For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, A Cancer Prevention Guide for the Human Race,” from Amazon, Barnes & Noble, Books-A-Million,Vroman’s Bookstore, and other fine bookstores!

On Thanksgiving Day, 2010, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books! On Christmas Day, 2010, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list!


Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


For a different perspective on Dr. Wascher, please click on the following YouTube link:

Texas Blues Jam


I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month. (More than 1.2 million health-conscious people visited Weekly Health Update in 2010!) As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.





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Even 15 Minutes of Exercise Per Day Reduces Death Risk

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A new clinical study shows that as little as 15 minutes of exercise per day, or 90 minutes per week, can significantly reduce the risk of premature death.





EVEN 15 MINUTES OF EXERCISE PER DAY REDUCES DEATH RISK

As I discuss in detail in my recent book, A Cancer Prevention Guide for the Human Race, regular exercise not only decreases the risk of cardiovascular disease, obesity, diabetes, and high blood pressure, but cancer as well.  Most experts recommend at least 30 minutes of moderate or vigorous exercise per day, and for at least 5 days per week.  You might respond to this recommendation by saying that you are simply too busy to spend this much time exercising (although, in truth, almost all of us can meet this goal if we are truly committed to living a healthy life…), and so you might, instead, simply choose not to exercise at all.  Well, what if I told you, then, that even shorter periods of moderate exercise, when performed regularly, can still significantly reduce your chances of early death due to cardiovascular disease, cancer, and other serious illnesses?

An important new prospective public health study from Taiwan appears in the current issue of the prestigious journal, The Lancet. In this extremely large study, 416,175 volunteers (199,265 men and 216,910 women) were followed for an average duration of 8 years. Based upon the amount of weekly exercise claimed by each volunteer, these men and women were then divided into 5 different groups: inactive, low, medium, high, or very high levels of weekly physical activity. This huge cohort of clinical research volunteers were then closely observed during the course of this public health study.

In this study, the volunteers in the “low” exercise group, who exercised for an average of only 92 minutes per week, were 14 percent less likely to die of any cause when compared to the “inactive” group volunteers, and these “minimal exercisers,” on average, lived for 3 years longer than the non-exercisers! Moreover, for every additional 15 minutes of daily exercise above the minimum of 15 minutes per day, death from all causes was reduced by an additional 4 percent, and death due to cancer wasreduced by an additional 1 percent!

Importantly, the beneficial health effects of even modest-to-moderate levels of exercise were experienced by all of the volunteers in this clinical research study, irrespective of age or gender. (Even volunteers with cardiovascular disease experienced these same significant health benefits from modest levels of regular daily exercise.)

The results of this enormous prospective public health study make it clear that even as little as 15 minutes of moderate exercise per day, or 90 minutes per week, can yield impressive health benefits, including a significant decrease in the risk of death due to all causes (including cancer), and a significant increase in lifespan.  Therefore, although most of us really can set aside at least half an hour per day, 5 or 6 days per week, to engage in moderate exercise, even more modest levels of regular exercise are still very worthwhile.  So, for those of you who are avoiding exercise altogether because you feel like you are unable to put in at least 30 minutes per day, the results of this important research study will, hopefully, motivate you to get up off of that couch and go out for at least 15 or 20 minutes of daily exercise!


 

For a comprehensive guide to living an evidence-based cancer prevention lifestyle, order your copy of my new book, A Cancer Prevention Guide for the Human Race.  For the price of a cheeseburger, fries, and a shake, you can purchase this landmark new book, in both paperback and e-book formats, and begin living an evidence-based cancer prevention lifestyle today!

For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, A Cancer Prevention Guide for the Human Race,” from Amazon, Barnes & Noble, Books-A-Million,Vroman’s Bookstore, and other fine bookstores!

On Thanksgiving Day, 2010, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books! On Christmas Day, 2010, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list!


Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity



Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author



For a different perspective on Dr. Wascher, please click on the following YouTube link:

Texas Blues Jam



I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month. (More than 1.2 million health-conscious people visited Weekly Health Update in 2010!) As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.





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Vitamin D Decreases Diabetes Risk

Welcome to Weekly Health Update


“A critical weekly review of important new research findings for health-conscious readers”



VITAMIN D DECREASES DIABETES RISK

I have written extensively about Vitamin D in the past, particularly in the areas of cancer prevention and cardiovascular disease prevention.  As regular readers of this column already know, Vitamin D, which actually functions more like a hormone than a vitamin, appears to be the only vitamin with clinically significant cancer prevention and cardiovascular disease prevention properties.  Now, a newly published clinical research study suggests that higher levels of Vitamin D in the blood may be associated with a lower risk of developing diabetes.  This new clinical study appears in the current issue of the British Journal of Nutrition.

This new report comes from a large cancer screening trial, the U.S. Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. A total of 2,500 patient volunteers were extensively surveyed and examined, and the following clinical data was collected for all participants: gender, age, geographical location, educational level, smoking history, body mass index (BMI), level of physical activity, and diet (including Vitamin D and calcium intake). Importantly, all of these study participants underwent testing for Vitamin D levels in their blood.

After adjusting for known risk factors associated with developing diabetes (such as BMI, physical activity level, smoking, and total dietary energy intake), the scientists conducting this study found a very strong association between Vitamin D levels in the blood and diabetes risk. In this moderately large clinical research study, the likelihood of having diabetes was more than three times greater among patient volunteers with low levels of Vitamin D (less than 72 pmol/L) when compared with patients who had higher levels of Vitamin D (103 pmol/L or greater).  Once again, this dramatic association between Vitamin D levels in the blood and diabetes risk persisted even after accounting for diabetes risk factors associated with each individual patient volunteer.

The findings of this prospectively conducted clinical research study add considerable weight to previous observations that diabetes is more common in people who live in areas where Vitamin D levels are known to be low throughout the population. Although the mechanism whereby Vitamin D may reduce the risk of diabetes is not known at this time, previous research in laboratory mice has demonstrated that chemical receptors for Vitamin D can be found in the pancreatic cells that produce insulin. This finding, together with an increasing volume of research data linking low Vitamin D levels to a higher risk of developing diabetes, suggests that Vitamin D probably plays a direct role in modulating insulin production by the pancreas, as well as in determining the sensitivity of our bodies to circulating insulin.


For additional evidence-based information on Vitamin D as part of a cancer prevention lifestyle, please click on the following links:

A Cancer Prevention Guide for the Human Race

Vitamin D Significantly Reduces Colorectal Cancer Risk

Vitamin D and Dementia

Breast Cancer Recurrence and Vitamin D

Vitamin D and Falls in the Elderly

Vitamin D and Colorectal Cancer Survival

Vitamin and Breast Cancer Risk

Vitamin D and Cardiovascular Disease


For a comprehensive guide to living an evidence-based cancer prevention lifestyle, order your copy of my new book, A Cancer Prevention Guide for the Human Race.  For the price of a cheeseburger, fries, and a shake, you can purchase this landmark new book, in both paperback and e-book formats, and begin living an evidence-based cancer prevention lifestyle today!

For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, A Cancer Prevention Guide for the Human Race,” from Amazon, Barnes & Noble, Books-A-Million,Vroman’s Bookstore, and other fine bookstores!

On Thanksgiving Day, 2010, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books! On Christmas Day, 2010, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list!


Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


For a different perspective on Dr. Wascher, please click on the following YouTube link:

Texas Blues Jam


I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month. (More than 1.2 million health-conscious people visited Weekly Health Update in 2010!) As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.




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Hesperidin in Orange Juice Improves Hypertension and Arterial Function

 

Welcome to Weekly Health Update


“A critical weekly review of important new research findings for health-conscious readers”


HESPERIDIN IN ORANGE JUICE IMPROVES

HYPERTENSION AND ARTERIAL FUNCTION

 

Polyphenols are chemical compounds that are found in most of the plant-based foods that we commonly eat.  As I discuss in detail in my new book, A Cancer Prevention Guide for the Human Race, some polyphenolic compounds, such as green tea flavonoids, soy-based isoflavones, quercetin, curcumin, and resveratrol, among other polyphenols, may possess important cancer prevention properties.  There is also abundant research data suggesting that diets rich in certain natural dietary polyphenols may be associated with a decreased risk of cardiovascular disease, as well.

Hesperidin, which is a flavonoid polyphenol, is found in a variety of plant-based foods, including oranges, orange juice, and other citrus fruits.  A newly published prospective, randomized, blinded clinical research study, which appears in the current issue of the American Journal of Clinical Nutrition, offers intriguing evidence that hesperidin may actually decrease the risk of cardiovascular disease in high-risk patients.

In this pilot study, 24 overweight (but otherwise healthy) men, ages 50 to 65 years, were subjected to 4-week intervals in each of three experimental groups.  The first group was assigned to drink 500 ml (17 ounces) of orange juice per day.  The second experimental group drank a “control drink” that appeared similar to orange juice, but which did not contain any actual orange juice.  However, this “sham orange juice” was fortified with hesperidin.  The third group was also assigned to drink the fake orange juice, and to which was added a supplement portrayed (to the study volunteers, and to the research nurses who administered the beverages to these research volunteers) as hesperidin, but which, in fact, was an inert placebo that contained no hesperidin or other polyphenols.

Physical examinations and blood tests were performed before and after the men rotated through each of these three experimental groups.

The findings of this small but high quality clinical research study were quite interesting.  When compared to the control group that consumed the fake orange juice and fake hesperidin supplement, the men in the other two experimental groups experienced a significant reduction in their blood pressure measurements.  Specifically, the diastolic blood pressure was significantly reduced, which suggests that these men experienced an improvement in the elasticity, or compliance, of their arteries, as a direct result of the hesperidin contained in both orange juice and in the non-juice beverage supplemented with hesperidin.  This observation was again confirmed through additional testing that revealed improved vascular compliance associated with hesperidin intake.  Moreover, this significant improvement in arterial compliance was observed only after the ingestion of hesperidin, and disappeared when these same men were retested after undergoing an overnight fast.  (Improved arterial compliance is associated with a reduced risk of cardiovascular disease, including high blood pressure, coronary artery disease, and stroke.)

To summarize the findings of this study, hesperidin, when taken in the form of either orange juice or as a supplement, appeared to significantly improve arterial elasticity, and lower diastolic blood pressure, in middle-aged overweight men.  While this brief study cannot prove that these observed and transient improvements in arterial compliance subsequently reduced the incidence of cardiovascular disease in these high-risk men, there is abundant data from other research studies linking improved arterial compliance with a reduced incidence of cardiovascular disease.  A much larger version of this small pilot study should now be repeated, and the volunteers in this larger study need to be followed for a much longer duration of time, before we can say, with certainty, that hesperidin significantly reduces the risk of cardiovascular disease.  That being said, the findings of this small but well-conducted, and elegant, randomized, controlled, prospective clinical research study are still quite compelling.

   

HAPPY HOLIDAYS TO OUR MANY HEALTH-CONSCIOUS

WEEKLY HEALTH UPDATE” READERS AROUND THE WORLD!

 

PEACE, LOVE, AND GOOD HEALTH TO ALL OF YOU!

 

For a complete discussion of the role of dietary flavonoids and polyphenols in cancer prevention, and other important evidence-based approaches to cancer prevention, order your copy of my new book, A Cancer Prevention Guide for the Human Race, now!  For the price of a cheeseburger, fries, and a shake, you can purchase this landmark new book, in both paperback and e-book formats, and begin living an evidence-based cancer prevention lifestyle today!

 

GIVE  THE  GIFT  OF  HEALTH  THIS  HOLIDAY  SEASON!  For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, A Cancer Prevention Guide for the Human Race,” from Amazon, Barnes & Noble, Books-A-Million, Vroman’s Bookstore, and other fine bookstores! 

On Thanksgiving Day, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com Top 100 Bestseller’s List for Kindle e-books!  On Christmas Day, 2010, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list!



Disclaimer: As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, a professor of surgery, a cancer researcher, an oncology consultant, and a widely published author


For a different perspective on Dr. Wascher, please click on the following YouTube link: 

Texas Blues Jam


I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month.  (As of 9/16/2010, more than 1,000,000 health-conscious people have logged onto Weekly Health Update so far this year!)  As always, I enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.



Click the following link to join Dr. Wascher on Facebook



 

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Metformin, Diabetes and Death

 

Welcome to Weekly Health Update



“A critical weekly review of important new research findings for health-conscious readers”


METFORMIN, DIABETES AND DEATH

Metformin is a diabetes medication that is of great interest to me, and to other cancer specialists, because of intriguing research data suggesting that it may reduce the risk of cancer occurrence and cancer recurrence in people with diabetes.  (Diabetes is, itself, a risk factor for certain types of cancer, including one of the most lethal of all cancers, pancreatic cancer.)

Metformin has been shown to be particularly beneficial in reducing the risk of death due to the complications of diabetes in overweight and obese patients, who are especially prone to developing diabetes.  However, there has been some concern regarding the potential safety of metformin in patients with preexisting cardiovascular disease and kidney disease, and so this first-line diabetes medication has not been extensively prescribed to diabetic patients with these diseases.  (Somewhat ironically, cardiovascular disease and kidney disease are, themselves, known complications of diabetes.)  For this reason, the clinical research study that I will be discussing in today’s column is especially important to the estimated 24 million patients in the United States, alone, who have diabetes, and to the hundreds of thousands of diabetic patients who have already developed cardiovascular disease and kidney disease in the US. 

This newly published study, which appears in the current issue of the Archives of Internal Medicine, reports on the results of the massive Reduction of Atherothrombosis for Continued Health (REACH) Study, which included 19,691 patients with documented diabetes.  (The researchers involved in the REACH Study have been following this huge number of patient volunteers since they enlisted in the study between December 2003 and December 2004.) 

The findings of this very large prospective public health study validate the findings of smaller prior clinical studies.  In this study, diabetic patients with cardiovascular disease were significantly less likely to die during the course of this study if they took metformin instead of other diabetes medications (or no diabetes medication at all).  The patients in this study who took metformin were 24 percent less likely to die when compared to the diabetic patients who did not take metformin.  Among patients with congestive heart failure, which has until recently has been considered a contraindication to taking metformin, the use of metformin was associated with a 31 percent reduction in death due to all causes.  Moreover, patients with other health conditions that have previously thought to preclude diabetes treatment with metformin also appeared to benefit from metformin in this study.  Diabetic patients with cardiovascular disease who were older than 65 years were 23 percent less likely to die if they took metformin, while patients with decreased kidney function (estimated creatinine clearance of 30 to 60 ml/minute) experienced a whopping 36 percent decrease in the risk of death if they took metformin. 

As this was an observational study (i.e., there were no randomized groups of patients, and there was no placebo-control group), it should be urgently followed with a prospective, randomized, placebo-controlled clinical research study to confirm these highly important clinical findings.  Taken together, however, the findings of this pivotal public health study are certain to eventually expand the number of patients with diabetes who will be considered eligible to receive metformin! 

 

For a complete discussion of metformin as a potential cancer prevention agent, as well as other important evidence-based approaches to cancer prevention, order your copy of my new book, A Cancer Prevention Guide for the Human Race, now!  For the price of a cheeseburger, fries, and a shake, you can purchase this landmark new book, and begin living an evidence-based cancer prevention lifestyle today!

  

Click the following link to join Dr. Wascher on Facebook




GIVE  THE  GIFT  OF  HEALTH  THIS  HOLIDAY  SEASON!  For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, A Cancer Prevention Guide for the Human Race,” from Amazon, Barnes & Noble, Books-A-Million, Vroman’s Bookstore, and other fine bookstores! 

On Thanksgiving Day, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com Top 100 Bestseller’s List for Kindle e-books!




Disclaimer: As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity



Dr. Wascher is an oncologic surgeon, a professor of surgery, a cancer researcher, an oncology consultant, and a widely published author



For a different perspective on Dr. Wascher, please click on the following YouTube link: 

Texas Blues Jam



I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month.  (As of 9/16/2010, more than 1,000,000 health-conscious people have logged onto Weekly Health Update so far this year!)  As always, I enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.


 

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Gum Disease (Gingivitis) and Breast Cancer Risk

 

Welcome to Weekly Health Update



“A critical weekly review of important new research findings for health-conscious readers”


pink-ribbon-image

   

 

OCTOBER IS NATIONAL BREAST CANCER

 

AWARENESS MONTH

 

 

 

GUM DISEASE (GINGIVITIS) AND BREAST CANCER RISK

Gum disease, also known as gingivitis, or periodontal disease, has been closely linked to an increased risk of heart disease.  Now, a newly published study from the renowned Karolinksa Institute in Sweden suggests that the risk of developing breast cancer may also be increased by chronic gum disease.  The results of this clinical research study appear in the current issue of Breast Cancer Research & Treatment.

In this prospective clinical research study, 3,273 women between the ages of 30 and 40 years were evaluated between 1985 and 2001.  Young women in this study who had documented chronic gum disease, or who had lost one or more molars due to gum disease, were more than twice as likely to be diagnosed with breast cancer when compared to women without periodontal disease (even after adjusting for known breast cancer risk factors in these young, healthy women).

Previous research has linked periodontal gum disease with an increased risk of other cancers, including cancers of the uterus, colon, rectum, prostate and pancreas.  However, up until now, there has been hardly any available research data linking gingivitis, or tooth loss due to periodontal disease, to breast cancer.

The exact mechanism whereby chronic gum disease increases cancer risk is unknown at this time.  (Some experts have proposed that bacteria from chronically inflamed gums may enter into the bloodstream, and induce an inflammatory response that, in turn, causes cancer formation.)  Irrespective of the true mechanism, however, certain cancers appear to be more common in people with chronic gum disease, even after adjusting for other known cancer risk factors.

If you experience red, swollen, sore, or bleeding gums, or premature tooth loss (or if your gums are retracting away from your teeth), then you may have periodontal disease (gingivitis).  Based upon recent research findings, this condition may not only increase your risk of heart disease, peripheral artery disease, stroke, and diabetes, but also cancer as well.  (Recent research has also linked periodontal disease in pregnant women with an increased risk of premature birth of their babies.)   If you notice any of these signs of periodontal disease, then please make an appointment to see your dentist for a complete check-up.

 

For a deeper discussion of known cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, A Cancer Prevention Guide for the Human Race,” from Amazon, Barnes & Noble, Books-A-Million, Vroman’s Bookstore, and other fine bookstores! 



 

Disclaimer: As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, a professor of surgery, a cancer researcher, an oncology consultant, and a widely published author



For a different perspective on Dr. Wascher, please click on the following YouTube link: 

Texas Blues Jam



I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month.  (As of 9/16/2010, more than 1,000,000 health-conscious people have logged onto Weekly Health Update so far this year!)  As always, I enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.



 

Bookmark and Share



 

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