The Four Critical Cardiovascular Disease Risks That You Can Change

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New research shows that high blood pressure, high cholesterol, diabetes, and smoking account for the vast majority of all deaths caused by cardiovascular disease.


 

THE FOUR CRITICAL CARDIOVASCULAR DISEASE RISKS THAT YOU CAN CHANGE

As I mention in my recent bestselling book, A Cancer Prevention Guide for the Human Race, many of the very same lifestyle and dietary habits that increase our risk of developing cancer also increase our risk of developing cardiovascular disease, including coronary artery disease, heart attacks (myocardial infarction), peripheral vascular disease, and stroke.  Likewise, adopting an evidence-based cancer prevention lifestyle can not only cut your cancer risk in half, but can also significantly reduce your risk of developing life-threatening cardiovascular disease as well.

A newly published research study, which was funded by the National Institutes of Health, provides, for the first time, a comprehensive assessment of the lifetime risks of developing cardiovascular disease based upon the following four health-related factors: blood pressure, cholesterol (lipid) levels in the blood, smoking status, and diabetes status.  Importantly, this huge meta-analysis study, which appears in the current issue of the New England Journal of Medicine, comprehensively analyzes the data from 18 different prior clinical research studies, which included 257,384 adult black and white men and women.  These research volunteers were assessed for these four critical cardiovascular risk factors every 10 years, beginning at age 45 and ending at age 75.  This enormous group of research volunteers was then closely followed, and the incidence of cardiovascular disease and death rates due to cardiovascular disease were then carefully evaluated and analyzed.

When looking at cardiovascular risks factors at age 55 as predictors of future cardiovascular disease risk, and the risk of death due to cardiovascular disease, the findings of this extremely large clinical study were striking.  In this study, a low-risk profile for cardiovascular disease was defined as total blood cholesterol less than 180 milligrams per deciliter (4.7 mmol per liter), average blood pressure less than 120/80 millimeters of mercury (mm Hg), nonsmoker status, and nondiabetic status.

Among the 55 year-old men and women who met all of the criteria for a low-risk profile for cardiovascular disease, their lifetime incidence of cardiovascular disease, through age 80, was remarkably lower than for the 55 year-olds who failed to meet two or more of the four low-risk criteria.  In fact, the risk of death due to cardiovascular disease, through age 80, was only 5 percent among the men who met all four low-risk criteria at age 55, while the men who met only two or fewer low-risk criteria faced a dramatic six-fold increase in the risk (30 percent) of dying of cardiovascular disease by age 80.  Among the women volunteers, only 6 percent of the women who met all four low-risk criteria went on to die of cardiovascular disease by age 80, while 21 percent of the women who failed to meet two or more of the four low-risk criteria died of cardiovascular disease between age 55 and age 80 (for a nearly four-fold increase in the risk of death).

Fatal and nonfatal coronary artery disease occurred in only 4 percent of the men who met all four low-risk criteria, but occurred in nearly 10 times as many of the men (38 percent) who failed to meet two or more of these four criteria.  The women who met all four low-risk criteria faced a less than 1 percent risk of fatal and nonfatal coronary artery disease, while the women who met two or fewer low-risk criteria experienced an 18 percent incidence of fatal and nonfatal coronary artery disease (for a more than 18-fold increase in risk).

The risk of fatal and nonfatal stroke was also significantly lower among men and women who met all four low-risk criteria for cardiovascular disease.  Among the men who met all four low-risk criteria, the incidence of stroke through age 80 was only about 2 percent, but quadrupled, to more than 8 percent, among the men who failed to meet two or more of the four low-risk criteria.  Among the women who met all four low-risk criteria, the incidence of stroke was about 5 percent, but more than doubled, to nearly 11 percent, among the women who failed to meet at least two of the low-risk criteria.

The findings of this very large study cannot be overstated in terms of its public health importance, as this is the only study that has prospectively assessed very large numbers of men and women, including both black and white adults, over long periods of time, and that has analyzed the long-term impact of the four most common risk factors for cardiovascular disease on incidence and death rates associated with cardiovascular disease.  As with the studies that I discuss in A Cancer Prevention Guide for the Human Race, the impact of lifestyle, diet, and other modifiable health-related factors on both cardiovascular disease risk and cancer risk is enormous, particularly when measured over the lifespan of the average adult.

The findings of this epic public health research study also add further weight to my strong belief, based upon my review of thousands of research studies, that we, as individuals, hold the key to improving our health, and to significantly reducing our risk of serious illness and premature death, by living evidence-based healthy lifestyles.  If your blood pressure is high, change your diet and increase your level of exercise, with the support of your doctor.  If diet and physical activity interventions alone do not correct your hypertension, then ask your doctor about medications for high blood pressure.  If you have diabetes, you also need to change your diet, increase your levels of physical activity, and safely lose any excess weight.  If these lifestyle changes do not completely resolve your high blood sugars, then you may also need to ask your doctor about medications for diabetes.  If you smoke, or use smokeless tobacco, stop immediately.  Finally, if your LDL and total cholesterol levels are high, then, once again, you need to be more careful about what you eat.  (The cancer-preventing foods and diets that I discuss in my book have also been linked to lower levels of blood cholesterol, as well as a much lower risk of cardiovascular disease.)  You may also need to increase your physical activity levels, and get your weight down to a healthy level, to improve your LDL and total cholesterol levels.  Once again, if these prudent lifestyle measures are not enough, by themselves, to bring your cholesterol levels down into the normal range, then your doctor may need to add a cholesterol-lowering medication as well.

The striking results of this important cardiovascular disease prevention study provide all of us with the key to maximally reducing our risk of developing—and dying from—largely preventable cardiovascular diseases, including heart disease and stroke.  Better long-term health (and a longer and more vigorous life) is within your grasp, and this study, in addition to my book, can show you the way forward.


For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, “A Cancer Prevention Guide for the Human Race,” from AmazonBarnes & NobleBooks-A-MillionVroman’s Bookstore, and other fine bookstores!

On Thanksgiving Day, 2010, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books! On Christmas Day, 2010, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list!



Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


For a different perspective on Dr. Wascher, please click on the following YouTube link:

Texas Blues Jam


I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people from around the world who visit this premier global health information website every month.  (More than 1.3 million pages of high-quality medical research findings were served to the worldwide audience of health-conscious people who visited Weekly Health Update in 2011!)  As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.


 








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Green Tea Significantly Reduces LDL (Bad Cholesterol)

Welcome to Weekly Health Update


“A critical weekly review of important new research findings for health-conscious readers”



 

GREEN TEA SIGNIFICANTLY REDUCES LDL (BAD CHOLESTEROL)

The cultivation and consumption of tea has continued, uninterrupted, for at least 12,000 years, based upon documentation from China.  Today, tea is the most commonly consumed beverage throughout the world other than water.  As I discuss in detail in my recent book, A Cancer Prevention Guide for the Human Race, a lot of health claims have been made for green tea, including a decrease in the risk of cancer and cardiovascular disease.  However, the available clinical and laboratory research data for green tea, unfortunately, includes multiple contradictory findings for these and other health-related claims.

As with most of the available disease prevention research that has been published so far, the majority of research data supporting beneficial health effects for green tea has been in the form of public health studies that rely upon dietary surveys or other research methodologies that produce low-level clinical research data. For this reason, new clinical research studies that rely upon prospective, randomized methods of conducting research, and which generate more valid and predictive data than survey-based studies, are essential in order to better understand the potential health benefits of green tea, if any.

A newly published paper in The American Journal of Clinical Nutrition offers important information about the potential health benefits of green tea, based upon a comprehensive analysis of all previously published prospective randomized clinical research trials looking at the effects of green tea consumption on blood lipids (e.g., total cholesterol; LDL-cholesterol, also known as the “bad cholesterol;” and HDL-cholesterol, also known as the “good cholesterol”). A total of 14 prospective, randomized, placebo-controlled clinical research studies were identified and analyzed in this comprehensive meta-analysis.

In this meta-analysis, green tea consumption, in the form of either a tea beverage or a green tea extract, was found to significantly and consistently reduce blood levels of total cholesterol (by an average of 7.2 mg/dL) and LDL-cholesterol (by an average of 2.2 mg/dL). At the same time, green tea consumption did not significantly affect blood levels of HDL-cholesterol (the “good cholesterol”). Thus, this important meta-analysis study provides powerful, high-level research evidence that green tea does indeed significantly lower total cholesterol and LDL-cholesterol levels. These effects of green tea on total cholesterol and LDL-cholesterol levels are the same primary effects of the enormously popular statin drugs, and which have been shown to significantly reduce the incidence of cardiovascular disease, including heart attack, sudden cardiac death, and stroke.

This is a powerful research study on the effects of green tea consumption on lipid profiles, because it is based solely upon data from high-level research studies, rather than the much more commonly published (and less expensive) survey-based public health studies that make up the majority of research in disease prevention.  I have, for many years now, included green tea in my diet, and while the impact of green tea, if any, on cancer risk is still open to debate, studies such as this one provide compelling evidence that the regular consumption of green tea may be an important part of a cardiovascular disease prevention lifestyle.



For a comprehensive guide to living an evidence-based cancer prevention lifestyle, order your copy of my new book, A Cancer Prevention Guide for the Human Race.  For the price of a cheeseburger, fries, and a shake, you can purchase this landmark new book, in both paperback and e-book formats, and begin living an evidence-based cancer prevention lifestyle today!

For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, A Cancer Prevention Guide for the Human Race,” from Amazon, Barnes & Noble, Books-A-Million,Vroman’s Bookstore, and other fine bookstores!

On Thanksgiving Day, 2010, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books! On Christmas Day, 2010, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list!


Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity



Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author



For a different perspective on Dr. Wascher, please click on the following YouTube link:

Texas Blues Jam



I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month. (More than 1.2 million health-conscious people visited Weekly Health Update in 2010!) As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.





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Dietary Fiber Significantly Reduces Risk of Death

Welcome to Weekly Health Update


“A critical weekly review of important new research findings for health-conscious readers”



 

Dietary Fiber Significantly Reduces Risk of Death

Most of us already know that a high-fiber diet is an important part of a healthy lifestyle. Numerous previous research studies have associated a high-fiber diet with a decreased incidence of cardiovascular disease, diabetes, and some forms of cancer. However, there is very little research information available that directly links a high-fiber diet with a decreased risk of death from these or other diseases. Now, a newly published public health study puts some actual numbers on the potential health benefits of adding fiber to your diet. This study appears in the current issue of the Archives of Internal Medicine.

The NIH (National Institutes of Health)-AARP Diet and Health Study is an enormous prospective public health study, which has enrolled 219,123 men and 168,999 women between the ages of 50 and 71 years. All of these research study participants completed extensive dietary questionnaires, and all were closely followed for an average of 9 years.

During nearly a decade of follow-up, 20,126 men and 11,330 women participating in this study died of various causes. When the researchers compared the dietary fiber intake of the volunteers who died with those who did not die, several important findings were identified. High levels of dietary fiber intake appeared to decrease the risk of death for both men and women by about 22 percent, overall. A diet rich in fiber was also specifically linked to a significant reduction in the risk of death due to cardiovascular disease, infection, and respiratory disease in both men and women; while men (but not women) appeared to have a lower risk of death due to cancer if they consumed a fiber-rich diet. Finally, as has also been found in previous diet-based studies (including several of the Mediterranean diet studies that I cite in my book, A Cancer Prevention Guide for the Human Race), dietary fiber from whole grains appeared to provide the greatest benefit in terms of reducing the risk of death due to all causes.

While this study suffers from the same limitations as all other survey-based public health studies, its prospective methodology and its enormous population of research volunteers make this a very powerful public health study. Its finding that a diet rich in fiber (derived from whole grains) significantly reduces the risk of death from the most common global causes of death offer all of us an important strategy to improve our health and longevity.



For a comprehensive guide to living an evidence-based cancer prevention lifestyle, order your copy of my new book, A Cancer Prevention Guide for the Human Race.  For the price of a cheeseburger, fries, and a shake, you can purchase this landmark new book, in both paperback and e-book formats, and begin living an evidence-based cancer prevention lifestyle today!

For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, A Cancer Prevention Guide for the Human Race,” from Amazon, Barnes & Noble, Books-A-Million,Vroman’s Bookstore, and other fine bookstores!

On Thanksgiving Day, 2010, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books! On Christmas Day, 2010, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list!


Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


For a different perspective on Dr. Wascher, please click on the following YouTube link:

Texas Blues Jam


I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month. (More than 1.2 million health-conscious people visited Weekly Health Update in 2010!) As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.





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Vitamin D Decreases Diabetes Risk

Welcome to Weekly Health Update


“A critical weekly review of important new research findings for health-conscious readers”



VITAMIN D DECREASES DIABETES RISK

I have written extensively about Vitamin D in the past, particularly in the areas of cancer prevention and cardiovascular disease prevention.  As regular readers of this column already know, Vitamin D, which actually functions more like a hormone than a vitamin, appears to be the only vitamin with clinically significant cancer prevention and cardiovascular disease prevention properties.  Now, a newly published clinical research study suggests that higher levels of Vitamin D in the blood may be associated with a lower risk of developing diabetes.  This new clinical study appears in the current issue of the British Journal of Nutrition.

This new report comes from a large cancer screening trial, the U.S. Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. A total of 2,500 patient volunteers were extensively surveyed and examined, and the following clinical data was collected for all participants: gender, age, geographical location, educational level, smoking history, body mass index (BMI), level of physical activity, and diet (including Vitamin D and calcium intake). Importantly, all of these study participants underwent testing for Vitamin D levels in their blood.

After adjusting for known risk factors associated with developing diabetes (such as BMI, physical activity level, smoking, and total dietary energy intake), the scientists conducting this study found a very strong association between Vitamin D levels in the blood and diabetes risk. In this moderately large clinical research study, the likelihood of having diabetes was more than three times greater among patient volunteers with low levels of Vitamin D (less than 72 pmol/L) when compared with patients who had higher levels of Vitamin D (103 pmol/L or greater).  Once again, this dramatic association between Vitamin D levels in the blood and diabetes risk persisted even after accounting for diabetes risk factors associated with each individual patient volunteer.

The findings of this prospectively conducted clinical research study add considerable weight to previous observations that diabetes is more common in people who live in areas where Vitamin D levels are known to be low throughout the population. Although the mechanism whereby Vitamin D may reduce the risk of diabetes is not known at this time, previous research in laboratory mice has demonstrated that chemical receptors for Vitamin D can be found in the pancreatic cells that produce insulin. This finding, together with an increasing volume of research data linking low Vitamin D levels to a higher risk of developing diabetes, suggests that Vitamin D probably plays a direct role in modulating insulin production by the pancreas, as well as in determining the sensitivity of our bodies to circulating insulin.


For additional evidence-based information on Vitamin D as part of a cancer prevention lifestyle, please click on the following links:

A Cancer Prevention Guide for the Human Race

Vitamin D Significantly Reduces Colorectal Cancer Risk

Vitamin D and Dementia

Breast Cancer Recurrence and Vitamin D

Vitamin D and Falls in the Elderly

Vitamin D and Colorectal Cancer Survival

Vitamin and Breast Cancer Risk

Vitamin D and Cardiovascular Disease


For a comprehensive guide to living an evidence-based cancer prevention lifestyle, order your copy of my new book, A Cancer Prevention Guide for the Human Race.  For the price of a cheeseburger, fries, and a shake, you can purchase this landmark new book, in both paperback and e-book formats, and begin living an evidence-based cancer prevention lifestyle today!

For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, A Cancer Prevention Guide for the Human Race,” from Amazon, Barnes & Noble, Books-A-Million,Vroman’s Bookstore, and other fine bookstores!

On Thanksgiving Day, 2010, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books! On Christmas Day, 2010, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list!


Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


For a different perspective on Dr. Wascher, please click on the following YouTube link:

Texas Blues Jam


I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month. (More than 1.2 million health-conscious people visited Weekly Health Update in 2010!) As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.




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Vitamin D and Death Due to Colorectal Cancer

Welcome to Weekly Health Update


“A critical weekly review of important new research findings for health-conscious readers”


VITAMIN D AND DEATH DUE TO COLORECTAL CANCER

Based upon recent high quality clinical research, only Vitamin D, among all vitamins, appears to have potentially significant cancer prevention effects.  However, as with all areas of clinical and laboratory research, one can find contradictory research results for Vitamin D, as well.

An innovative prospective clinical research study is now reporting its results, which appear to link Vitamin D deficiency to colorectal cancer death rates.  As with previous research studies, the findings of this study strongly suggest that Vitamin D deficiency may be linked with a higher risk of death due to colorectal cancer.  The findings of this clinical research study appear in the current issue of the journal Cancer.

An interesting and unique aspect of this particular clinical research study was its evaluation of the potential impact of Vitamin D deficiency on the well-known increased risk of death due to colorectal cancer that has been observed in African-Americans when compared to Caucasian patients.  As our bodies create active Vitamin D from exposure of our skin to sunlight, and as people with darkly pigmented skin are more prone to developing Vitamin D deficiency, when compared to lightly-pigmented people, the authors of this study sought to assess the potential colorectal cancer risk impact of Vitamin D deficiency on patient volunteers with darkly pigmented skin.

In this large public health study, the Third National Health and Nutrition Examination Survey (NHANES III), which was conducted between 1988 and 1994, blood levels of Vitamin D were measured in study volunteers.  Patients with a Vitamin D level of less than 20 ng/dL were considered to be deficient in Vitamin D.

As previous public health studies have also shown, the results of this study indicated that African-Americans are twice as likely to die of colorectal cancer when compared to Caucasians.  When blood levels of Vitamin D were considered, specifically, the increased risk of dying from colorectal cancer observed in African-American patients decreased by 40 percent among those African-Americans who had normal levels of Vitamin D in their blood.  (These results, therefore, suggest that at least 40 percent of the increased risk of dying from colorectal cancer in African-American persons is likely to be caused by Vitamin D deficiency.)  When patients of all races were considered in terms of Vitamin D deficiency as a risk factor for death due to colorectal cancer,patient volunteers with a blood level of Vitamin D less than 20 ng/dL were more than twice as likely (i.e., a 211 percent increase in risk)to die of colorectal cancer during the course of this prospective research study, when compared with patients who had normal Vitamin D levels.

In summary, this large prospectively conducted public health study found, as have previous studies, a significant association between Vitamin D deficiency and the risk of dying from colorectal cancer.  (Previous Vitamin D studies have also identified a 25 to 40 percent reduction in the incidence of colorectal cancer, and death due to colorectal cancer, in study volunteers with blood Vitamin D levels in the 30 to 40 ng/dL range.)  While not all clinical research studies have shown this level of colorectal cancer risk reduction associated with normal blood levels of Vitamin D, this particular study joins a growing list of clinical studies that appear to show a significant reduction in colorectal cancer risk associated with adequate levels of Vitamin D in the blood.

As excessive Vitamin D intake can cause significant health problems (especially in patients with kidney disease and parathyroid gland disease), you should check with your doctor prior to considering the use of Vitamin D supplements.

 

For a complete discussion of Vitamin D as a cancer prevention agent, and other evidence-based approaches to cancer risk and cancer prevention, order your copy of my new book, A Cancer Prevention Guide for the Human Race.  For the price of a cheeseburger, fries, and a shake, you can purchase this landmark new book, in both paperback and e-book formats, and begin living an evidence-based cancer prevention lifestyle today!


For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, “A Cancer Prevention Guide for the Human Race,” from AmazonBarnes & NobleBooks-A-Million,Vroman’s Bookstore, and other fine bookstores!

On Thanksgiving Day, 2010, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books! On Christmas Day, 2010, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list!


Disclaimer: As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, a professor of surgery, a cancer researcher, an oncology consultant, and a widely published author



For a different perspective on Dr. Wascher, please click on the following YouTube link:

Texas Blues Jam



I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month. (More than 1.2 million health-conscious people visited Weekly Health Update in 2010!) As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.





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Obesity, Diabetes and Breast Cancer Recurrence Risk

 

Welcome to Weekly Health Update


“A critical weekly review of important new research findings for health-conscious readers”


OBESITY, DIABETES AND BREAST CANCER RECURRENCE RISK

 

Obesity and diabetes have both been linked to an increased risk of certain types of cancer (including breast cancer), as discussed in detail in my new book, A Cancer Prevention Guide for the Human Race.  (The single greatest risk factor for adult-onset diabetes is obesity.)

Not only have obesity and diabetes been strongly linked to an increased risk of developing cancer, but these two chronic illnesses, which have become epidemic in our modern culture, also appear to increase the risk of breast cancer recurrence, and death due to recurrent breast cancer.  Two newly published clinical research studies, which appear in the current issue of the Journal of Clinical Oncology, reveal just how strongly obesity and diabetes impact the incidence of breast cancer recurrence, and death due to breast cancer, among women who have previously been diagnosed with this common form of cancer.

In the first study, the impact of obesity on breast cancer recurrence, and the risk of death due to breast cancer, was assessed among 18,967 women with a previous diagnosis of breast cancer in Denmark.   Using body mass index (BMI) scores, which indicate whether a person is obese or not, the findings of this study were quite concerning.  (A BMI between 18.5 and 24.9 indicates a healthy weight, while a BMI of 25 to 29.9 indicates that a person is overweight, and a BMI of 30 or more indicates obesity.)

In this very large public health study with long-term follow-up, female breast cancer survivors with a BMI of 30 or more (when compared to women with a BMI below 25) were, stage-for-stage, 46 percent more likely to be diagnosed with metastatic breast cancer within 10 years of their original diagnosis, and 38 percent more likely to die of metastatic breast cancer within 30 years of their original breast cancer diagnosis.

In the second study, 604 women with a prior diagnosis of breast cancer were evaluated with a blood test that measures insulin secretion levels (serum C-peptide).  Fasting C-peptide levels were measured in these breast cancer survivors 3 years after their initial cancer diagnosis, and this group of research volunteers was then followed for about a decade.  In this study, a 1nanogram per milliliter (ng/mL) increase in serum C-peptide levels, even among women without diabetes, was associated with a 31 percent increase in the risk of death from any cause over the duration of this study.  This same miniscule 1 ng/mL increase in C-peptide blood levels was also associated with a 35 percent increase in the risk of death specifically due to breast cancer.  (The increased risk of death associated with rising C-peptide levels among women with diabetes was even higher.)  Thus, this study is one of the first ever to show that rising levels of insulin secretion in women either with or without diabetes is associated with a significantly higher risk of death due to recurrent breast cancer.

Taken together, the findings of these two very important clinical studies add to the findings of previous studies that have linked both obesity and diabetes with an increased likelihood of breast cancer recurrence and death due to recurrent breast cancer.  These, and other, clinical studies also continue to show that the chemotherapy and hormonal therapy that is routinely given following the diagnosis of breast cancer appears to be less effective in obese women and in diabetic women, when compared to women without either of these chronic illnesses.  The findings of these studies also mirror cancer risk and cancer prevention studies that have linked breast cancer risk with both obesity and diabetes.

If you have a history of breast cancer, and you are significantly overweight, then it is essential that you discuss a prudent weight loss program with your doctor, including a healthy diet and a regimen of regular aerobic exercise (as discussed in my new book).  Likewise, if you have diabetes, both weight loss interventions and tight control of your diabetes are essential for reducing your risk of breast cancer recurrence, and your overall risk of premature death from cancer and other serious illnesses associated with diabetes.

 

For a complete discussion of the role of obesity, diabetes, diet, and exercise in cancer prevention, and other important evidence-based approaches to cancer prevention, order your copy of my new book, A Cancer Prevention Guide for the Human Race, now!  For the price of a cheeseburger, fries, and a shake, you can purchase this landmark new book, in both paperback and e-book formats, and begin living an evidence-based cancer prevention lifestyle today!

 

GIVE  THE  GIFT  OF  HEALTH  THIS  HOLIDAY  SEASON!  For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, A Cancer Prevention Guide for the Human Race,” from Amazon, Barnes & Noble, Books-A-Million, Vroman’s Bookstore, and other fine bookstores! 

 

On Thanksgiving Day, 2010, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.comTop 100 Bestseller’s List” for Kindle e-books!  On Christmas Day, 2010, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list!



Disclaimer: As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, a professor of surgery, a cancer researcher, an oncology consultant, and a widely published author


For a different perspective on Dr. Wascher, please click on the following YouTube link: 

Texas Blues Jam



I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month.  (As of 9/16/2010, more than 1,000,000 health-conscious people had logged onto Weekly Health Update in 2010!)  As always, I enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.




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Metformin, Diabetes and Death

 

Welcome to Weekly Health Update



“A critical weekly review of important new research findings for health-conscious readers”


METFORMIN, DIABETES AND DEATH

Metformin is a diabetes medication that is of great interest to me, and to other cancer specialists, because of intriguing research data suggesting that it may reduce the risk of cancer occurrence and cancer recurrence in people with diabetes.  (Diabetes is, itself, a risk factor for certain types of cancer, including one of the most lethal of all cancers, pancreatic cancer.)

Metformin has been shown to be particularly beneficial in reducing the risk of death due to the complications of diabetes in overweight and obese patients, who are especially prone to developing diabetes.  However, there has been some concern regarding the potential safety of metformin in patients with preexisting cardiovascular disease and kidney disease, and so this first-line diabetes medication has not been extensively prescribed to diabetic patients with these diseases.  (Somewhat ironically, cardiovascular disease and kidney disease are, themselves, known complications of diabetes.)  For this reason, the clinical research study that I will be discussing in today’s column is especially important to the estimated 24 million patients in the United States, alone, who have diabetes, and to the hundreds of thousands of diabetic patients who have already developed cardiovascular disease and kidney disease in the US. 

This newly published study, which appears in the current issue of the Archives of Internal Medicine, reports on the results of the massive Reduction of Atherothrombosis for Continued Health (REACH) Study, which included 19,691 patients with documented diabetes.  (The researchers involved in the REACH Study have been following this huge number of patient volunteers since they enlisted in the study between December 2003 and December 2004.) 

The findings of this very large prospective public health study validate the findings of smaller prior clinical studies.  In this study, diabetic patients with cardiovascular disease were significantly less likely to die during the course of this study if they took metformin instead of other diabetes medications (or no diabetes medication at all).  The patients in this study who took metformin were 24 percent less likely to die when compared to the diabetic patients who did not take metformin.  Among patients with congestive heart failure, which has until recently has been considered a contraindication to taking metformin, the use of metformin was associated with a 31 percent reduction in death due to all causes.  Moreover, patients with other health conditions that have previously thought to preclude diabetes treatment with metformin also appeared to benefit from metformin in this study.  Diabetic patients with cardiovascular disease who were older than 65 years were 23 percent less likely to die if they took metformin, while patients with decreased kidney function (estimated creatinine clearance of 30 to 60 ml/minute) experienced a whopping 36 percent decrease in the risk of death if they took metformin. 

As this was an observational study (i.e., there were no randomized groups of patients, and there was no placebo-control group), it should be urgently followed with a prospective, randomized, placebo-controlled clinical research study to confirm these highly important clinical findings.  Taken together, however, the findings of this pivotal public health study are certain to eventually expand the number of patients with diabetes who will be considered eligible to receive metformin! 

 

For a complete discussion of metformin as a potential cancer prevention agent, as well as other important evidence-based approaches to cancer prevention, order your copy of my new book, A Cancer Prevention Guide for the Human Race, now!  For the price of a cheeseburger, fries, and a shake, you can purchase this landmark new book, and begin living an evidence-based cancer prevention lifestyle today!

  

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GIVE  THE  GIFT  OF  HEALTH  THIS  HOLIDAY  SEASON!  For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, A Cancer Prevention Guide for the Human Race,” from Amazon, Barnes & Noble, Books-A-Million, Vroman’s Bookstore, and other fine bookstores! 

On Thanksgiving Day, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com Top 100 Bestseller’s List for Kindle e-books!




Disclaimer: As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity



Dr. Wascher is an oncologic surgeon, a professor of surgery, a cancer researcher, an oncology consultant, and a widely published author



For a different perspective on Dr. Wascher, please click on the following YouTube link: 

Texas Blues Jam



I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month.  (As of 9/16/2010, more than 1,000,000 health-conscious people have logged onto Weekly Health Update so far this year!)  As always, I enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.


 

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Mammograms Between 40 and 49 Years of Age

 

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“A critical weekly review of important new research findings for health-conscious readers”


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OCTOBER IS NATIONAL BREAST CANCER

 

AWARENESS MONTH

 

 

 

MAMMOGRAMS BETWEEN 40 AND 49 YEARS OF AGE

Both patients and their physicians were stunned last year when the U.S. Department of Health and Human Services’ U.S. Preventive Services Task Force (USPSTF) recommended against routine annual screening mammograms in women between the age of40 and 49 years (as has been the standard recommendation in the United States, and in most countries around the world, for many years).  The USPSTF’s recommendations quickly set off a firestorm of debate regarding the calculations and public health considerations used by the USPSTF to arrive at this surprising recommendation.  Since the USPSTF released its recommendations in the fall of 2009, most breast cancer specialists and breast cancer advocacy groups have continued to recommend that women who are at average risk of developing breast cancer begin routine annual screening mammograms at age 40. 

As I extensively discuss in my new book, A Cancer Prevention Guide for the Human Race, there is ample available clinical research data showing that screening mammograms detect breast cancer at an earlier stage than other commonly available screening methods, and that survival is improved in women in whom breast cancer is first detected by a mammogram (as opposed to the detection of a palpable or visible breast mass).

Now, a newly published large-scale public health study from Sweden, which appears in the current issue of the journal Cancer, offers further important evidence that the routine use of annual screening mammograms among women between 40 and 49 years of age significantly reduces the risk of dying from breast cancer.

In this enormous study, women between the ages of 40 and 49 years were separated into two groups, depending upon whether or not they underwent annual screening mammograms between 1986 and 2005 (the average duration of patient follow-up in this study was a very impressive 16 years).  In this very powerful research study, young women who underwent annual mammograms accounted for 7.3 million “person-years” of observation, while the young women who did not undergo mammograms accounted for a similarly astonishing 8.8 million “person-years” of observation within this landmark public health study. 

When the number of breast cancer deaths were assessed in both of these huge groups of young women, the women who underwent routine annual mammograms were found to be 29 percent less likely to die of breast cancer when compared to the young women who did not undergo annual mammograms!  (In public health terms, this 29 percent observed reduction in the death rate due to breast cancer is highly clinically significant!)

 

This public health study, which encompassed the entire country of Sweden, is the largest mammography study of its kind, and its findings are both powerful and persuasive in defense of beginning routine annual screening mammograms at the age of 40 in women who are at average risk of developing breast cancer.  It is my hope that the dramatic findings of this huge clinical study will now lay to rest any lingering doubts regarding the effectiveness of screening mammograms, beginning at 40 years of age, in reducing the risk of death due to breast cancer.

 

 

In recognition of Breast Cancer Awareness Month, I urge our tens of thousands of regular Weekly Health Update readers to join in the global fight against breast cancer.  There are numerous organizations and groups, in virtually every community, that are sponsoring fundraising activities throughout October, including the Susan G. Komen Race for the Cure.  Another opportunity to participate (and at no cost!) is to vote for the Dr. Susan Love Research Foundation Army of Women project in the Pepsi Refresh competition!  There are also many other worthwhile and deserving fundraising programs available for everyone to become involved in! 

 

For an evidence-based discussion of the critical importance of breast cancer screening, including mammograms, in a cancer prevention lifestyle, order your copy of my new landmark book, “A Cancer Prevention Guide for the Human Race,” from Amazon or Barnes & Noble, Books-A-Million, Vroman’s Bookstore, and other fine bookstores! 


 


 

Disclaimer: As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity



Dr. Wascher is an oncologic surgeon, a professor of surgery, a cancer researcher, an oncology consultant, and a widely published author



For a different perspective on Dr. Wascher, please click on the following YouTube link: 

Texas Blues Jam


I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month.  (As of 9/16/2010, more than 1,000,000 health-conscious people have logged onto Weekly Health Update so far this year!)  As always, I enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.



 

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Vitamin D, Cardiovascular Disease, Cancer, and Death

 

Welcome to Weekly Health Update


“A critical weekly review of important new research findings for health-conscious readers”



VITAMIN D, CARDIOVASCULAR DISEASE, CANCER AND DEATH

Among all of the vitamins, only Vitamin D appears to have clinically significant health benefits in reducing the risk of death associated with cardiovascular disease, fractures, and cancer, based upon numerous recent clinical research study findings (for a comprehensive update on the role of Vitamin D as part of a cancer prevention lifestyle, please see my new book, A Cancer Prevention Guide for the Human Race, which is now available from Amazon and Barnes & Noble). 

A newly-published clinical research study, which appears in the current issue of the American Journal of Clinical Nutrition, prospectively evaluated 1,194 elderly men (average age was 71 years) over a period of nearly 13 years.   Blood levels of Vitamin D were measured in these elderly male men, and the results of these blood tests were then correlated with subsequent health outcomes. 

In this prospective public health study, with extensive long-term follow-up, very low and very high blood levels of Vitamin D were associated with a significantly increased risk of death.  In fact, a whopping 50 percent increase in the risk of death was associated with both very low (<46 nmol/L) and very high (>98 nmol/L) concentrations of Vitamin D in the blood.  Death due to cancer was two times more common with very low Vitamin D levels, while very high levels of Vitamin D increased the risk of death due to cancer by almost three-fold.  At the same time, death due to cardiovascular disease was nearly twice as likely in elderly men with very low Vitamin D levels, but not in men with very high levels of this hormone-like vitamin.

The findings of this prospective public health study add to the enormous volume of previously published clinical research data on the health effects of Vitamin D.  As this study suggests, there may be an optimal concentration of Vitamin D in the blood that is associated with a decreased risk of death from both cardiovascular disease and cancer.  Meanwhile, a healthy diet that emphasizes fresh fruits, brightly-colored fresh vegetables, whole grains, and fatty fish (and minimal red meat and other animal-based foods) is your best bet for a long and healthy life! 

For a comprehensive, evidence-based review of the importance of Vitamin D and diet in a cancer prevention lifestyle, order your copy of my new landmark book, A Cancer Prevention Guide for the Human Race, from Amazon or Barnes & Noble! 



Disclaimer: As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, a professor of surgery, a cancer researcher, an oncology consultant, and a widely published author


For a different perspective on Dr. Wascher, please click on the following YouTube link: 
Texas Blues Jam


I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month.  (As of 9/16/2010, more than 1,000,000 health-conscious people have logged onto Weekly Health Update so far this year!)  As always, I enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.



 

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Low-Carb Diet and Risk of Death

September 12, 2010 by admin  
Filed under Atkins diet, Weekly Health Update, diet, health, heart disease

 

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“A critical weekly review of important new research findings for health-conscious readers”


LOW-CARB DIET AND RISK OF DEATH

The debate regarding the potential health benefits of low-carbohydrate diets has gone on for over four decades now.  During this period, the pendulum has swung, repeatedly, back and forth between “low-carb” and “high-carb” diets, combined with controversies regarding low-fat versus high-fat diets, as various diet and health gurus have weighed in with their recommendations.  (Witness one of the more popular and enduring of these “have it your way” dietary fads, the now discredited Atkins Diet, which advocated a reduction in carbohydrate intake combined with a free pass on meat consumption, and other animal-based sources of fat and protein.)

Currently, there is really no meaningful controversy regarding the linkage between meat consumption and an increased risk of cardiovascular disease and cancer.  However, the impact of dietary carbohydrate intake on health continues to be the subject of some debate.   Unfortunately, as is often the case regarding debates about lifestyle- and diet-related health factors, there is very little high-level clinical research data evidence available to support the more ambitious claims made by “experts” at either spectrum of the carbohydrate debate.  Now, a newly published study, which appears in the current issue of the Annals of Internal Medicine, offers a fresh, evidence-based assessment of the impact of carbohydrate and meat intake on the risk of early death. 

In this prospectively conducted cohort study, which was funded by the National Institutes of Health, the results of two very large prospective public health studies were combined.  More than 85,000 women who participated in the vast Nurses’ Health Study, and nearly 46,000 male physicians who participated in the Health Professionals Follow-up Study, were included in this analysis.  These healthy female and male volunteers were without clinical evidence of cardiovascular disease, diabetes, or cancer when they entered into these studies.  An almost unprecedented duration of clinical follow-up was available for these two enormous groups of research volunteers, which makes this combined cohort study extremely powerful.  On average, the male study volunteers have already been followed for 20 years, while the women volunteers have been followed for an average of 26 years.  All of these 129,716 men and women completed multiple validated diet questionnaires at various time points in these two clinical studies, and the data collected from these questionnaires was then used to analyze the impact of diet on mortality (death) risk among this huge group of nurses and physicians.

Two sub-groups of volunteers were assessed, based upon their dietary preferences, and these two sub-groups of men and women were then compared with the remaining study volunteers.   The first dietary preference sub-group consisted of men and women who preferred a low-carbohydrate diet associated with the frequent intake of meat and other animal-based foods (along the lines of the Atkins Diet), while the second sub-group consisted of men and women who routinely consumed a low-carbohydrate diet that emphasized vegetable and fruit sources of protein (instead of animal sources of protein).

Over the very long duration of the two combined studies, 12,555 deaths occurred among the women (including 2,458 deaths due to cardiovascular disease).  Among the men, there were 8,678 deaths (including 2,746 deaths due to cardiovascular disease).

In the group of men and women who favored an Atkins-like diet, emphasizing a low carbohydrate intake but liberal meat consumption (and other animal-based foods, as well), the risk of premature death from any cause (when compared to a low-carb, low-meat diet) was elevated by 23 percent.  This same dietary preference was also associated with a 14 percent increase in the risk of death due to, specifically, cardiovascular disease.

In contrast, the men and women who consumed a diet low in both carbohydrates and animal products appeared to significantly reduce their risk of death due to all causes, as well as their mortality due to cardiovascular disease, specifically.  In this group of research volunteers, mortality due to any cause was reduced by 20 percent, while death due to cardiovascular disease, specifically, was reduced by 23 percent.

The findings of this very large prospective public health study, with its extremely long duration of clinical follow-up, confirms the findings of other recent (and less powerful) small clinical studies that a diet rich in vegetables, but low in both carbohydrates and animal-derived foods, confers a very significant benefit in terms of the overall risk of death, and the risk of death from cardiovascular disease, in particular.

Excessive carbohydrate intake has been previously shown to increase the risk of diabetes, obesity, cardiovascular disease, cancer, and other serious illnesses.  At the same time, increased meat intake has also been clearly shown to raise the risk of many of these same life-threatening illnesses, as well.  From this huge prospective cohort clinical study, we can see highly significant health benefits associated with long-term adherence to a healthy diet rich in vegetables and low in carbohydrates and animal-derived foods.  (And there are not many health benefits that can trump a significant reduction in your risk of premature death!)

 

For an evidence-based review of the critical importance of diet in a cancer prevention lifestyle, watch for the publication of my new landmark book, “A Cancer Prevention Guide for the Human Race,” later this month.



Disclaimer: As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, a professor of surgery, a cancer researcher, an oncology consultant, and a widely published author


For a different perspective on Dr. Wascher, please click on the following YouTube link: 

Texas Blues Jam


I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit our premier global health information website every month.  As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.



 

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