90 is the New 60



A new public health study finds that today’s nonagenarians enjoy much better health than their predecessors.


 

90 IS THE NEW 60

As I discuss in my book, A Cancer Prevention Guide for the Human Race, we are rapidly growing older as a population.  As our population continues to age, a record number of men and women are now surviving into their ninth and tenth decades of life.  Unfortunately, though, super-elderly men and women are highly prone to significant physical and cognitive frailty.  However, a fascinating new public health study from Denmark suggests that today’s nonagenarians (people who are in their 90s) may be far healthier, both physically and mentally, than their predecessors.  This public health study appears in the current issue of the journal The Lancet.

In this study, 2,262 men and women born in 1905, and aged 93, were compared with a second group of research volunteers.  The second group of volunteers consisted of 1,584 men and women born in 1915, all of whom were 95 years old.  Both groups of research volunteers underwent testing of both their physical fitness levels and their cognitive (brain) function levels.  The findings of this study were quite intriguing.

One interesting finding of this innovative study was that men and women born in 1915 had a 28 percent greater chance of surviving to age 93 than people born just 10 years earlier (i.e., in 1905), while the likelihood of reaching one’s 95th birthday was 32 percent higher for folks born in 1915 compared to those born in 1905.

Another interesting finding was that the 95 year-old volunteers born in 1915 scored significantly higher on cognitive (brain) function tests than the younger (93 year-old) volunteers born in 1905.

While the group of volunteers born in 1905 had similar levels of physical fitness as the volunteers born in 1915, the 95 year-old volunteers born in 1915 reported higher levels of daily physical activity at home when compared with their 93 year-old counterparts born in 1905.

In view of concerns about the frailty that often comes with advanced age, the findings of this study offer hope that future super-elderly senior citizens may enjoy a much higher level of both physical and cognitive function than their predecessors.  As our population continues to grow ever older, the findings of this study may prove to be of considerable importance.

 

For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my bestselling book, “A Cancer Prevention Guide for the Human Race,” from AmazonBarnes & NobleBooks-A-MillionVroman’s Bookstore, and other fine bookstores!


Within one week of publication, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books. Within three months of publication, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.com Top 100 New Book Releases in Cancer” list.


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Satisfaction with Life May Actually Increase with Age

Brain Changes in the Elderly May Increase Susceptibility to Being Scammed


 


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According to recent Bureau of Labor Statistics, the unemployment rate for veterans who served on active duty between September 2001 and December 2011 is more than 12 percent.  A new website, Veterans in Healthcare, seeks to connect veterans with potential employers.  If you are a veteran who works in the healthcare field, or if you are an employer who is looking for physicians, advanced practice professionals, nurses, corpsmen/medics, or other healthcare professionals, then please take a look at Veterans in Healthcare. As a retired veteran of the U.S. Army, I would also like to personally urge you to hire a veteran whenever possible.


Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


 

I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people from around the world who visit this premier global health information website every month.  Over the past 12 months, 3.5 million pages of high-quality medical research findings were served to the worldwide audience of health-conscious readers.  As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.


 


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Testosterone Supplements in Frail Elderly Men

February 21, 2010 by Robert Wascher  
Filed under Uncategorized

 

Welcome to Weekly Health Update



  “A critical weekly review of important new research findings for health-conscious readers” 


 

TESTOSTERONE SUPPLEMENTS IN FRAIL ELDERLY MEN

 

As we age, we tend to lose both muscle mass and bone density.  These adverse effects of aging often lead to an increased risk of generalized weakness, early fatigue, imbalance and falls, bone fractures, long-term disability, and hospitalization or other forms of chronic institutionalization.  In turn, these complications of frailty in the elderly are significantly associated with an increased risk of death.

While an elixir of eternal youth has not yet been discovered (despite many claims to the contrary over the centuries), some of the causes of aging-related frailty can be treated.  Sex hormone replacement therapy in the elderly has been a major focus of clinical intervention, in both men and women, in an effort to reverse many of the debilitating effects of aging, including declines in muscle mass, bone density, and sexual function.  However, the true risks and benefits of sex hormone replacement therapy have not always been well understood.  Indeed, within the past decade, old assumptions about the safety of hormone replacement therapy have been called into question by high-level prospective, randomized, placebo-controlled, blinded clinical research trials, including the recent and disturbing (but not altogether surprising) findings that long-term combination hormone replacement therapy in postmenopausal women is associated with a significant increase in the risk of both breast cancer and cardiovascular disease.

Although aging men do not experience an abrupt and total loss of testicular function, unlike the complete loss of ovarian function that occurs in women following menopause, testicular function does dramatically and progressively decline with advancing age.  Significant decreases in the levels of testosterone (and other “androgens”) in the blood often leads to decreased muscle mass and bone density which, in turn, can result in reduced strength and balance, and an increased risk of falls and serious injuries. 

Testosterone replacement therapy has been shown to be effective in improving muscle mass and bone density (and sexual function) in older men with very low testosterone levels (hypogonadism).  However, the role of testosterone replacement therapy in men with borderline-low circulating levels of androgen hormones has been much less clear.   As with sex hormone replacement therapy in postmenopausal women, there are known side effects associated with male sex hormone replacement therapy.  These include enlargement of the prostate gland (benign prostatic hypertrophy, or BPH), liver disease (especially with oral testosterone supplements), fluid retention, decreased fertility, breast enlargement and pain (gynecomastia), and a potential increase in the risk of prostate cancer, among others.

A newly published research study, in the Journal of Clinical Endocrinology & Metabolism, evaluated 274 men who were 65 years of age or older, and who were determined, by validated clinical criteria, to be either “intermediate-frail” or “frail.”  All of these men were also confirmed to have “borderline-low” levels of testosterone in their blood. 

In this randomized, prospective, placebo-controlled, double-blind study (which is the “gold standard” method of performing clinical research), these older men were randomly assigned to receive either transdermal testosterone therapy (50 mg per day) or a placebo gel that appeared identical to the testosterone gel.  These treatments were continued for 6 months.  The researchers then assessed both groups of men in terms of their muscle strength, muscle mass, body fat, overall level of physical function, and self-reported quality-of-life.

At the end of 6 months, the men who had been secretly randomized to the testosterone gel group were found to have experienced significant improvements in both muscle mass and muscle strength, as well as a decrease in total body fat.  Overall physical function in the “intermediate-frail” and “frail” older men also significantly improved.  Finally, and not surprisingly, self-reported physical health and sexual health satisfaction scores were substantially improved among the men who, unknown to them at the time, had received the testosterone gel.

Thus, the findings of this prospective, randomized, controlled clinical research trial certainly suggest a potential role for transdermal testosterone supplementation in frail older men with borderline-low testosterone levels.  At the same time, continued follow-up of the men in this study who elected to continue receiving testosterone supplementation is indicated, as the rather short duration of this study (6 months) is not long enough to identify the long-term benefits and risks of androgen replacement therapy.

If you are an older man who is experiencing significant frailty and disability due to progressive muscle mass and bone density loss, and you have borderline-low or low testosterone levels, then you might wish to discuss the potential benefits of a monitored testosterone supplementation regimen with your physician, or with an Endocrinologist who specialize in male endocrinology (Andrology).

 

On a related topic, please also see my recent column on the use of Vitamin D to decrease the risk of falls and fractures in the elderly:

 

http://doctorwascher.com/Archives/10-11-09.htm 




In view of the extreme devastation and human misery brought about in Haiti and Chile by the recent earthquakes, Weekly Health Update asks our tens of thousands of caring readers to give generously to established charities that are currently working in that country to assist the injured, the ill, and the homeless there.  There are many such legitimate charities, including the following two:


http://www.redcross.org/

http://www.imcworldwide.org/haiti


Disclaimer: As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, a professor of surgery, a cancer researcher, an oncology consultant, and a widely published author



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