New Vaccine and Antibodies May Prevent Heart Disease





 

New studies suggest that heart disease may someday become preventable with vaccine and antibody therapy.


 

 

NEW VACCINE AND ANTIBODIES MAY PREVENT HEART DISEASE

As I discuss in my bestselling book, A Cancer Prevention Guide for the Human Race, cancer has recently surpassed cardiovascular disease to become the #1 cause of death in many areas of the world.  However, coronary artery disease, peripheral vascular disease and stroke continue to kill millions of people around the world every year.

In general, atherosclerotic artery disease arises when thick “plaques” develop on the inner walls of arteries.  These plaques can rupture, thus exposing their inner surfaces, which can then activate the components of the blood responsible for forming blood clots.  The progression of blood clots on the surface “atheromatous” plaques within the arteries of the heart and brain can directly cause blockage of affected arteries, leading to a heart attack or stroke, respectively.  Even more commonly, however, clumps of clot and atheromatous plaque can break off and travel downstream, where they block coronary artery and brain artery branches, causing heart attacks (myocardial infarction) and strokes, respectively.  As inflammation, caused by our bodies’ white blood cells and antibodies, plays an important role in the development of atherosclerosis, scientists have been testing both vaccines and blocking antibodies in laboratory animals in an effort to prevent (or even reverse) the development of atherosclerosis, in the hope that heart attacks and strokes (and limb loss, in the case of peripheral vascular disease) can be prevented.

Two experimental new approaches to preventing and treating cardiovascular disease were unveiled at the Frontiers in Cardiovascular Biology conference this past week in London, and they have generated a great deal of interest among cardiovascular disease experts around the world.

In one recent study, which was performed using laboratory mice, an experimental vaccine (“CVX-210”) that reprograms inflammatory white bloods cells into inflammation-fighting white blood cells was evaluated.  In this mouse study, the CVX-210 vaccine was able to reduce the extent of arterial atherosclerosis by 60 to 70 percent!  While treatments that are effective in laboratory mice do not always work in humans, the manufacturer of the CVX-210 vaccine, CardioVax, is currently awaiting FDA approval to begin preliminary human clinical trials.

A second immunological approach to the prevention and treatment of arterial atherosclerosis involves the use of blocking antibodies that are designed to target oxidized LDL cholesterol (the “bad cholesterol,” which is a major component of atherosclerotic plaques, and which also participates in the inflammatory cascade that leads directly to plaque formation.)  When injected into a patient, these antibodies attack oxidized LDL particles and, theoretically, block the formation of atherosclerotic plaques.  At this time, there is an ongoing human clinical trial that is evaluating this “BI-204” human monoclonal antibody.  (In preclinical studies, BI-204 has already been shown to decrease the extent of existing arterial atherosclerotic plaques in laboratory animals by as much as 50 percent!)

In addition to the potential of the CVX-210 vaccine and the BI-204 human monoclonal antibody to significantly reduce, and possibly prevent, arterial atherosclerosis, these two still experimental therapies, if proven to be safe and effective in humans, would also be available for use in combination with current cardiovascular disease prevention therapies, including the cholesterol blocking statin drugs, high blood pressure medications, and diabetes medications.  (When considered together, these three current, conventional treatments for the most common risk factors for cardiovascular disease are estimated to reduce the risk of heart attack by about 40 percent.)  Because all of these therapies target different risk factors for cardiovascular disease, combining CVX-210 and/or BI-204 with current conventional cardiovascular disease prevention therapies could dramatically further reduce our risk of cardiovascular disease and significantly prolong our lives in the future.

As a disease prevention expert, I consider these two new developments to be of potentially enormous importance in the area of cardiovascular disease prevention and treatment.  Given that inflammation is known to play an important role in the development of both cardiovascular disease and cancer, I will be very interested to see if these two new experimental approaches to cardiovascular disease prevention and treatment also have a beneficial risk on cancer risk as well!



For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my bestselling book, “A Cancer Prevention Guide for the Human Race,” from AmazonBarnes & NobleBooks-A-MillionVroman’s Bookstore, and other fine bookstores!

Within one week of publication, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books. Within three months of publication, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list.


Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


For a lighthearted perspective on Dr. Wascher, please click on the following YouTube link:

Texas Blues Jam


I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people from around the world who visit this premier global health information website every month.  (More than 1.3 million pages of high-quality medical research findings were served to the worldwide audience of health-conscious people who visited Weekly Health Update in 2011!)  As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.


 





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Lifestyle, Diet and Diabetes Risk

Welcome to Weekly Health Update


New research reveals the profound impact of diet, obesity, and lifestyle factors on diabetes risk.



 

 

LIFESTYLE, DIET AND DIABETES RISK

Along with the incidence of obesity, the incidence of diabetes has recently skyrocketed in the United States and around the world.  The list of health complications associated with diabetes is frightening, and includes heart disease, peripheral vascular disease, stroke, kidney failure, progressive blindness, and as I discuss in my book, A Cancer Prevention Guide for the Human Race, an increased risk of cancer.

Now, a newly published clinical research study, which included more than 200,000 adult volunteers, sheds important light on the major lifestyle-associated risk factors for this life-threatening disease.  Nearly 2 million adults will be newly diagnosed with diabetes this year in the United States, and nearly 80 million Americans are currently living with diabetes at this time. In fact, diabetes has become such a serious public health problem that it is now considered the seventh leading cause of death in the United States!

This newly published prospective public health study appears in the current issue of the Annals of Internal Medicine, and was sponsored by the National Heart, Lung, and Blood Institute and the National Cancer Institute, as part of the National Institutes of Health-AARP Diet and Health Study.

A total of 114, 996 men and 92,483 women, aged 50 to 71 years, participated in this public health study; and this huge group of research volunteers was closely followed for an average of 10 years. Importantly, none of these research volunteers had diabetes, heart disease, or cancer at the time they initially joined this research study.

After evaluating diet, level of physical activity, smoking status, and alcohol intake, this enormous group of research volunteers was assessed for the risk of onset of diabetes according to these lifestyle factors. Altogether, about 10 percent of the men and 8 percent of the women went on to develop diabetes during the 10-year course of this public health study. When compared to men who ate poorly and did not exercise, and who also smoked and regularly consumed alcohol, the men who had very healthy behaviors in these same areas had a 39 percent lower risk of developing diabetes, while the women with healthy lifestyle behaviors experienced a 57 percent lower risk of diabetes when compared to the women with unhealthy lifestyle behaviors. Even more impressive was the additive role of obesity on diabetes risk. When all of the previously mentioned healthy lifestyle behaviors were combined with the absence of being overweight or obese, men experienced a whopping 72 percent decrease in the risk of diabetes, while women experienced an extraordinary 84 percent reduction in the risk of developing diabetes. Importantly, these dramatic reductions in the risk of diabetes were maintained even among the men and women who had a family history of diabetes or obesity.

This huge prospective public health study adds important and helpful information to our understanding regarding the most important risk factors for diabetes, and reveals just how important eating a healthy diet, maintaining a healthy weight, getting regular exercise, abstaining from tobacco use, and minimizing alcohol intake are to the prevention of diabetes.  Other large public health studies have also conclusively linked these healthy lifestyle-associated behaviors with a significant reduction in the risk of cardiovascular disease (including heart disease, peripheral vascular disease, and stroke) and cancer, as well!




For a comprehensive guide to living an evidence-based cancer prevention lifestyle, order your copy of my new book, A Cancer Prevention Guide for the Human Race.  For the price of a cheeseburger, fries, and a shake, you can purchase this landmark new book, in both paperback and e-book formats, and begin living an evidence-based cancer prevention lifestyle today!

For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, A Cancer Prevention Guide for the Human Race,” from Amazon, Barnes & Noble, Books-A-Million,Vroman’s Bookstore, and other fine bookstores!

On Thanksgiving Day, 2010, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books! On Christmas Day, 2010, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list!


Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


For a different perspective on Dr. Wascher, please click on the following YouTube link:

Texas Blues Jam


I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month. (More than 1.2 million health-conscious people visited Weekly Health Update in 2010!) As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.





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Beer May Prevent Heart and Arterial Disease (Atherosclerosis)

 

Welcome to Weekly Health Update


“A critical weekly review of important new research findings for health-conscious readers”


BEER MAY PREVENT HEART AND

ARTERIAL DISEASE (ATHEROSCLEROSIS)

 

Dietary polyphenols, which are potent antioxidants, are thought to have a wide range of potential health benefits, including a reduction in the risk of cardiovascular disease and some forms of cancer.  Polyphenols are found in many plant-based foods that we eat, including that age-old beverage, beer.

A newly published research study, which appears in the current issue of the British Journal of Nutrition, has drawn some very important conclusions about the potential health benefits of alcohol-free beer.

As we age, the inner lining of our arteries often becomes progressively more diseased.  As our arteries age, complex “plaques” can form on the inner surfaces of our arteries (a process known as atherosclerosis), which may then result in a critical narrowing of important arteries, including the arteries that nourish our heart, kidneys, brain, legs and feet, and other important sites in our bodies.  When these atherosclerotic plaques bleed or rupture, the blood supply to our vital organs can then become compromised, resulting in heart attack, kidney failure, stroke, and the potential loss of toes, feet, and legs.

In this interesting laboratory study, mice with a genetic predisposition towards atherosclerosis were fed either alcohol-free lager beer or alcohol-free dark beer for 20 weeks.  (Mice within a third group, the control group, did not receive any alcohol-free beer.)  The results of this study were striking.  The mice that received alcohol-free lager (“light”) beer experienced 44 percent less atherosclerosis within the main artery in their bodies (the aorta), while the mice that consumed the more polyphenol-rich alcohol-free dark beer were noted to have 51 percent less atherosclerosis in their aortas (versus the control group mice).

Additional results from this animal study indicated that the consumption of alcohol-free beer significantly also reduced the presence of substances that cause the lining of arteries (endothelium) to become “sticky,” such that inflammatory white blood cells, muscle cells, and fat cells begin to “stick” to the interior of these arteries, causing arterial atherosclerosis.

While I always caution that the findings of laboratory animal research studies are very often not validated in subsequent human studies, this particular animal study is exciting in that not only was a significant reduction in atherosclerosis observed among the mice that received alcohol-free beer supplements, but also the actual biochemical mechanisms linked to the development of atherosclerosis, in both mice and men (with apologies to Steinbeck…), were also shown to be inhibited by alcohol-free beer supplementation.

The findings of this study raise the possibility that beer polyphenols may be able to significantly reduce the risk of atherosclerosis, particularly in people with an increased predisposition towards premature atherosclerosis and cardiovascular disease.  (I must stress that the frequent consumption of beer, or other beverages that contain alcohol, is associated with a variety of potentially serious health problems, including liver disease, GI tract bleeding, pancreatitis, cancers of the breast and GI tract, and other life-threatening illnesses.  However, fortunately, based upon the results of this laboratory animal study, alcohol-free beer appears to retain the potential health benefits of traditional beer, but without the harmful health effects associated with beer that contains alcohol.)

 

For a complete discussion of the role of dietary polyphenols in cancer prevention, and other important evidence-based approaches to cancer prevention, order your copy of my new book, A Cancer Prevention Guide for the Human Race.  For the price of a cheeseburger, fries, and a shake, you can purchase this landmark new book, in both paperback and e-book formats, and begin living an evidence-based cancer prevention lifestyle today!

 

For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, A Cancer Prevention Guide for the Human Race,” from Amazon, Barnes & Noble, Books-A-Million, Vroman’s Bookstore, and other fine bookstores!   

 

On Thanksgiving Day, 2010, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books!  On Christmas Day, 2010, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.com Top 100 New Book Releases in Cancer” list!  

 



Disclaimer: As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity



Dr. Wascher is an oncologic surgeon, a professor of surgery, a cancer researcher, an oncology consultant, and a widely published author



For a different perspective on Dr. Wascher, please click on the following YouTube link: 
Texas Blues Jam



I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month.  (More than 1.2 million health-conscious people visited Weekly Health Update in 2010!)  As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.






 

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