Fish Oil May Increase Prostate Cancer Risk



A new study suggests that high levels of fish oil in the blood may increase prostate cancer risk.


 

FISH OIL MAY INCREASE PROSTATE CANCER RISK

As I discuss in my book, A Cancer Prevention Guide for the Human Race, there is research evidence available suggesting that omega-3 fatty acids, which are abundant in fatty fishes and fish oil supplements, may potentially decrease the risk of breast cancer and other types of cancer.  Indeed, in a recent column I reviewed a new study that strongly suggested a role for fish oil supplements in the prevention of breast cancer (Fish Oil May Decrease Breast Cancer Risk).  Now, a newly published clinical research study suggests that fish oil may increase the risk of prostate cancer, and aggressive forms of prostate cancer in particular.  This newly published study appears in the current issue of the Journal of the National Cancer Institute.

In this study, 834 men diagnosed with prostate cancer were compared with 1,393 age-matched men without prostate cancer. All of these men underwent measurement of the levels of fish oil-derived omega-3 fatty acids (EPA, DPA and DHA) in their blood.  After measuring and comparing the levels of fish-derived omega-3 fatty acids in the blood of these research volunteers, the researchers found that the volunteers with the highest levels of these omega-3 fatty acids were 44 percent more likely to be diagnosed with favorable forms of prostate cancer, and 71 percent more likely to be diagnosed with more aggressive forms of prostate cancer, when compared to the men with the lowest levels of fish-derived omega-3 fatty acids in their blood. Overall, men with the highest levels of fish-derived omega-3 fatty acids in their blood were 43 percent more likely to be diagnosed with any form of prostate cancer when compared to men with the lowest levels of fish oil-derived omega-3 fatty acids in their blood.  On the other hand, men with the highest blood levels of fatty acids derived from plants (omega-6 fatty acids) actually had a 23 percent lower likelihood of developing any form of prostate cancer.

As I have pointed out often before, studies such as this one can point out potential associations between specific lifestyle habits and the risk of cancer (or other diseases).  However, they cannot truly prove a “cause-and-effect” relationship between individual lifestyle factors and disease risk.  To arrive at this higher level of proof, a large prospective, randomized, placebo-controlled, blinded clinical research trial is necessary.  However, given that this is not the first research study to link high levels of fish-derived omega-3 fatty acids with an increase in prostate cancer risk, I have recently cut back on my own intake of both fish and fish oil supplements.  (Like millions of other people who take fish oil supplements and who regularly eat fish, I long ago added these items to my diet in the hope that I would significantly reduce my risk of cardiovascular disease.  However, a recent prospective, randomized, placebo-controlled clinical study of fish oil supplements in patients at elevated risk for cardiovascular disease showed no apparent reduction in the risk of heart attacks or strokes, or other cardiovascular disease events, among the research volunteers who were randomized to receive fish oil supplements.)

Until a large-scale prospective, randomized, blinded, placebo-controlled study is performed to validate the findings of this “case-cohort” public health study, it would seem prudent to cut back on daily fish oil supplements, which I myself have done.

For more information on evidence-based approaches to cancer prevention, please read more on this important health topic in A Cancer Prevention Guide for the Human Race.

 

For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my bestselling book, “A Cancer Prevention Guide for the Human Race,” from AmazonBarnes & Noble, Books-A-Million, Vroman’s Bookstore, and other fine bookstores!

Within one week of publication, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books. Within three months of publication, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.com Top 100 New Book Releases in Cancer” list.

 

Join Dr. Wascher on Facebook


Additional Links for Robert A. Wascher, MD, FACS

New Facebook Page for A Cancer Prevention Guide for the Human Race

CNN Story on CTCA’s Organic Farm in the Phoenix Area

Dr. Wascher Discusses Signs & Symptoms of Skin Cancer

Profile of Dr. Wascher by Oncology Times

Bio of Dr. Wascher at Cancer Treatment Centers of America

Dr. Wascher Discusses Predictions of Decreased Cancer Risk on azfamily.com

Dr. Wascher Discusses Environmental Risk Factors for Breast Cancer on Sharecare

Dr. Wascher Answers Questions About Cancer on talkabouthealth.com

Dr. Wascher Discusses Cancer Prevention Strategies on LIVESTRONG

Dr. Wascher Discusses Cancer Prevention on Newsmax

Dr. Wascher Answers Questions About Cancer Risk & Cancer Prevention on The Doctors Radio Show

Dr. Wascher Discusses Lymphedema After Breast Surgery on cancerlynx.com

Dr. Wascher Discusses Hormone Replacement Therapy & Breast Cancer Risk on cancerlynx.com

Dr. Wascher Discusses Chronic Pain After Mastectomy for Breast Cancer on cancerlynx.com

Dr. Wascher Discusses Sentinel Lymph Node Biopsy for Cancer on cancersupportivecare.com

Dr. Wascher Discusses the Role of Exercise in Cancer Prevention on Open Salon

Dr. Wascher Discusses Aspirin as a Potential Preventive Agent for Pancreatic Cancer on eHealth Forum

Dr. Wascher Discusses Obesity & Cancer Risk on eHealth Forum

Dr. Wascher Discusses the Role of Radiation Therapy in the Treatment of Breast Cancer on Sharecare

Dr. Wascher Discusses the Treatment of Stomach Cancer on Sharecare

Dr. Wascher Discusses the Management of Metastatic Cancer of the Liver on Sharecare

Dr. Wascher Discusses Obesity & Cancer Risk on hopenavigators.com

Dr. Wascher Discusses Hormone Replacement Therapy & Breast Cancer Risk on interactmd.com

Dr. Wascher Discusses Thyroid Cancer on health2fit.com

 

Links to Other Breaking Health News

FDA Approves New Brain Scan to Assess for ADHD in Kids

Epidemic of Drug Overdose Deaths Among Middle-Aged Women

Man Loses 155 Pounds

Naked Mole Rat May Provide Important Cancer Prevention Clue

The Effects of Poverty on the Brain

Half of Us Will Develop Cancer in Our Lifetimes

Protein Critical for Long-Term Memory Identified

HPV Virus and Cancer Risk

Probiotics May Decrease Antibiotic-Associated Diarrhea caused by C. difficile

3-D Printer Helps to Save Baby’s Life

Experimental Drug May Reduce Heart Damage after Heart Attack

Vitamin D May Improve Asthma Symptoms

Doctor Provides Patients with Own Feces for Fecal Transplants

Rising Arsenic Levels in Chicken

Dramatic Increase in Suicide Rate Among Middle Aged Americans Over the Past Decade

Cutting Umbilical Cord Too Soon May Cause Anemia in Newborns

Spiny New Bandage May Speed Healing of Skin Wounds

Study Confirms that Men Really Do Have Trouble Reading the Thoughts of Women

Deadly new Bird Flu Strain Cases Continue to Rise

Abdominal Fat Increases Kidney Disease Risk

Increasing Dietary Potassium & Decreasing Salt Intake Reduces Stroke Risk

A New Explanation for the Link Between Red Meat & Cardiovascular Disease

Deadly New Bird Flu Identified in China

Infection Risk: Keeping an Eye on Your Dentist

Couple Loses 500 Pounds in Two Years

Coffee May Reduce Crash Risk for Long-Distance Drivers

Tiny Implant Tells Your Smart Phone When You Are Having A Heart Attack

Transplanted Kidney Causes Death Due to Rabies

Eating While Distracted Increases Calorie Intake

Resistant Bacteria are on the Rise

High Levels of Stress Linked to an Increase in Heart Disease Risk

Small Snacks Cut Hunger as Well as Big Snacks

Poor Sleep May Increase the Risk of Heart Failure

Ancient Mummies Found to Have Heart Disease by CT Scan

Physically Fit Kids Do Better on Math & Reading Tests

How Melanoma Skin Cancer Evades the Immune System

Possible Link Between BPA and Asthma

Baby Boomers Appear Less Healthy Than Their Parents

The Biology of Love in the Brain

Millennials May be the Most Stressed-Out Generation

Even Modest Alcohol Intake Raises Cancer Risk

Why Do Boys Receive Lower Grades than Girls?

Negative Emotions and Feelings Can Damage Your Health

Canker Sore Drug Cures Obesity (At Least in Mice…)

How Technology is Changing the Practice of Medicine

New Salt Intake Guidelines for Children

High Levels of Distress in Childhood May Increase Risk of Heart Disease in Adulthood

Quitting Tobacco by Age 40 Restores a Normal Lifespan in Smokers

Cancer Death Rates Continue to Fall

Self-Help Books Improve Depression

Marines Try Mindfulness and Meditation to Reduce PTSD

Dying Nurse Volunteers Herself to Teach Nursing Students about the Dying

Regular Walks Cut Stroke Risk

Falling Asleep While Driving More Common than Previously Thought

Celebrity Health Fads Debunked

Obesity Among Young Children May Be Declining

Fresh Fruits & Vegetables May Reduce Breast Cancer Risk

Satisfaction with Life May Actually Increase with Age

Brain Changes in the Elderly May Increase Susceptibility to Being Scammed

 


Dr. Wascher’s Home Page



According to recent Bureau of Labor Statistics, the unemployment rate for veterans who served on active duty between September 2001 and December 2011 is more than 12 percent.  A new website, Veterans in Healthcare, seeks to connect veterans with potential employers.  If you are a veteran who works in the healthcare field, or if you are an employer who is looking for physicians, advanced practice professionals, nurses, corpsmen/medics, or other healthcare professionals, then please take a look at Veterans in Healthcare. As a retired veteran of the U.S. Army, I would also like to personally urge you to hire a veteran whenever possible.


Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


 

I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people from around the world who visit this premier global health information website every month.  Over the past 12 months, 3.3 million pages of high-quality medical research findings were served to the worldwide audience of health-conscious readers.  As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.


 


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Coffee May Reduce Prostate Cancer Risk



A large new study strongly links coffee consumption to a decreased risk of developing prostate cancer.


 

COFFEE MAY REDUCE PROSTATE CANCER RISK

An estimated 240,000 men will be diagnosed with prostate cancer in the United States in 2013, and nearly 30,000 American men will die from this form of cancer in 2013. As is the case with breast cancer in women, prostate cancer is the most common type of cancer (other than skin cancer) in men and the second most common cause of cancer death in men. (Sadly, lung cancer, an almost completely preventable form of cancer, remains the #1 cancer killer in both men and women.) As I discuss in my cancer prevention book for lay readers (A Cancer Prevention Guide for the Human Race), in the chapter dedicated to prostate cancer, there are multiple modifiable lifestyle factors that have been linked to prostate cancer risk.

Coffee consumption, like many other dietary factors potentially linked to prostate cancer risk, has been evaluated in several previous public health studies, but the data from these mostly small-scale studies has been contradictory. However, a newly published large-scale prospective public health study suggests that coffee consumption may, indeed, be associated with a significant reduction in the risk of developing prostate cancer. This important new study appears in the current issue of theBritish Journal of Cancer.

This Japanese study recruited 18,853 men between the ages of 40 and 79 to participate in this very large prospective public health study. A previously validated survey was given to all of these men, and questions about dietary habits, including coffee consumption, were included in this survey. This very large group of middle-aged and elderly men was closely followed for an average of 11 years, during which 318 of these nearly 19,000 male volunteers were diagnosed with prostate cancer.

Compared with the men who did not drink coffee at all, men who drank coffee occasionally (i.e., less than one cup per day, on average) were 19 percent less likely to develop prostate cancer, although this finding did not quite reach statistical significance. As would be expected if coffee truly played a role in reducing prostate cancer risk, increasing levels of coffee consumption were associated with greater reductions in prostate cancer risk. For example, men who drank 1 to 2 cups of coffee per day were, on average, 27 percent less likely to develop prostate cancer (compared to nondrinkers), while men who drank 3 or more cups of coffee per day were 37 percent less likely to be diagnosed with prostate cancer. (These latter two findings were found to be statistically significant.)

While I frequently caution readers that the findings of most small-scale public health studies on disease prevention are not definitive, larger prospectively conducted public health studies, such as this one, and particularly studies with long-term follow-up (such as this one), are much more likely to generate valid observations and conclusions. Since there is little apparent downside to moderate coffee consumption, the findings of this study would appear to support the consumption of coffee (again, in moderation…) as a component of what I call, in A Cancer Prevention Guide for the Human Race, an “evidence-based cancer prevention lifestyle.” So, go ahead and have a cuppa joe, or two, each day, men!

 

For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my bestselling book, “A Cancer Prevention Guide for the Human Race,” from AmazonBarnes & Noble, Books-A-Million, Vroman’s Bookstore, and other fine bookstores!

Within one week of publication, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books. Within three months of publication, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.com Top 100 New Book Releases in Cancer” list.


Join Dr. Wascher on Facebook

 

Additional Links for Robert A. Wascher, MD, FACS

New Facebook Page for A Cancer Prevention Guide for the Human Race

CNN Story on CTCA’s Organic Farm in the Phoenix Area

Dr. Wascher Discusses Signs & Symptoms of Skin Cancer

Profile of Dr. Wascher by Oncology Times

Bio of Dr. Wascher at Cancer Treatment Centers of America

Dr. Wascher Discusses Predictions of Decreased Cancer Risk on azfamily.com

Dr. Wascher Discusses Environmental Risk Factors for Breast Cancer on Sharecare

Dr. Wascher Answers Questions About Cancer on talkabouthealth.com

Dr. Wascher Discusses Cancer Prevention Strategies on LIVESTRONG

Dr. Wascher Discusses Cancer Prevention on Newsmax

Dr. Wascher Answers Questions About Cancer Risk & Cancer Prevention on The Doctors Radio Show

Dr. Wascher Discusses Lymphedema After Breast Surgery on cancerlynx.com

Dr. Wascher Discusses Hormone Replacement Therapy & Breast Cancer Risk on cancerlynx.com

Dr. Wascher Discusses Chronic Pain After Mastectomy for Breast Cancer on cancerlynx.com

Dr. Wascher Discusses Sentinel Lymph Node Biopsy for Cancer on cancersupportivecare.com

Dr. Wascher Discusses the Role of Exercise in Cancer Prevention on Open Salon

Dr. Wascher Discusses Aspirin as a Potential Preventive Agent for Pancreatic Cancer on eHealth Forum

Dr. Wascher Discusses Obesity & Cancer Risk on eHealth Forum

Dr. Wascher Discusses the Role of Radiation Therapy in the Treatment of Breast Cancer on Sharecare

Dr. Wascher Discusses the Treatment of Stomach Cancer on Sharecare

Dr. Wascher Discusses the Management of Metastatic Cancer of the Liver on Sharecare

Dr. Wascher Discusses Obesity & Cancer Risk on hopenavigators.com

Dr. Wascher Discusses Hormone Replacement Therapy & Breast Cancer Risk on interactmd.com

Dr. Wascher Discusses Thyroid Cancer on health2fit.com

 

Links to Other Breaking Health News

Naked Mole Rat May Provide Important Cancer Prevention Clue

The Effects of Poverty on the Brain

Half of Us Will Develop Cancer in Our Lifetimes

Protein Critical for Long-Term Memory Identified

HPV Virus and Cancer Risk

Probiotics May Decrease Antibiotic-Associated Diarrhea caused by C. difficile

3-D Printer Helps to Save Baby’s Life

Experimental Drug May Reduce Heart Damage after Heart Attack

Vitamin D May Improve Asthma Symptoms

Doctor Provides Patients with Own Feces for Fecal Transplants

Rising Arsenic Levels in Chicken

Dramatic Increase in Suicide Rate Among Middle Aged Americans Over the Past Decade

Cutting Umbilical Cord Too Soon May Cause Anemia in Newborns

Spiny New Bandage May Speed Healing of Skin Wounds

Study Confirms that Men Really Do Have Trouble Reading the Thoughts of Women

Deadly new Bird Flu Strain Cases Continue to Rise

Abdominal Fat Increases Kidney Disease Risk

Increasing Dietary Potassium & Decreasing Salt Intake Reduces Stroke Risk

A New Explanation for the Link Between Red Meat & Cardiovascular Disease

Deadly New Bird Flu Identified in China

Infection Risk: Keeping an Eye on Your Dentist

Couple Loses 500 Pounds in Two Years

Coffee May Reduce Crash Risk for Long-Distance Drivers

Tiny Implant Tells Your Smart Phone When You Are Having A Heart Attack

Transplanted Kidney Causes Death Due to Rabies

Eating While Distracted Increases Calorie Intake

Resistant Bacteria are on the Rise

High Levels of Stress Linked to an Increase in Heart Disease Risk

Small Snacks Cut Hunger as Well as Big Snacks

Poor Sleep May Increase the Risk of Heart Failure

Ancient Mummies Found to Have Heart Disease by CT Scan

Physically Fit Kids Do Better on Math & Reading Tests

How Melanoma Skin Cancer Evades the Immune System

Possible Link Between BPA and Asthma

Baby Boomers Appear Less Healthy Than Their Parents

The Biology of Love in the Brain

Millennials May be the Most Stressed-Out Generation

Even Modest Alcohol Intake Raises Cancer Risk

Why Do Boys Receive Lower Grades than Girls?

Negative Emotions and Feelings Can Damage Your Health

Canker Sore Drug Cures Obesity (At Least in Mice…)

How Technology is Changing the Practice of Medicine

New Salt Intake Guidelines for Children

High Levels of Distress in Childhood May Increase Risk of Heart Disease in Adulthood

Quitting Tobacco by Age 40 Restores a Normal Lifespan in Smokers

Cancer Death Rates Continue to Fall

Self-Help Books Improve Depression

Marines Try Mindfulness and Meditation to Reduce PTSD

Dying Nurse Volunteers Herself to Teach Nursing Students about the Dying

Regular Walks Cut Stroke Risk

Falling Asleep While Driving More Common than Previously Thought

Celebrity Health Fads Debunked

Obesity Among Young Children May Be Declining

Fresh Fruits & Vegetables May Reduce Breast Cancer Risk

Satisfaction with Life May Actually Increase with Age

Brain Changes in the Elderly May Increase Susceptibility to Being Scammed

 


 


Dr. Wascher’s Home Page



According to recent Bureau of Labor Statistics, the unemployment rate for veterans who served on active duty between September 2001 and December 2011 is more than 12 percent.  A new website, Veterans in Healthcare, seeks to connect veterans with potential employers.  If you are a veteran who works in the healthcare field, or if you are an employer who is looking for physicians, advanced practice professionals, nurses, corpsmen/medics, or other healthcare professionals, then please take a look at Veterans in Healthcare. As a retired veteran of the U.S. Army, I would also like to personally urge you to hire a veteran whenever possible.


Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


 

I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people from around the world who visit this premier global health information website every month.  Over the past 12 months, 3.2 million pages of high-quality medical research findings were served to the worldwide audience of health-conscious readers.  As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.


 


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Resveratrol May Reduce Cancer Risk and Cancer Cell Growth



 

A new study suggests that resveratrol may reduce cancer risk and cancer progression.



 

 

 

RESVERATROL MAY REDUCE CANCER RISK AND CANCER CELL GROWTH

As I discuss in my bestselling book, A Cancer Prevention Guide for the Human Race, resveratrol, a plant-derived phenol, has been found, in laboratory studies, to potentially reduce the risk of both cardiovascular disease and cancer, and may increase longevity as well (at least in laboratory animals…).

Resveratrol’s anti-cancer effects have been observed in multiple laboratory studies using cancer cells grown in culture and in laboratory animals.  (Unfortunately, there is very little clinical data available regarding the effects of resveratrol in humans.) However, the precise mechanisms whereby resveratrol may inhibit the development and growth of cancer cells remain unclear at this time.  Now, a newly published study, which appears in the journal Cancer Prevention Research, sheds some important scientific light on at least one mechanism whereby resveratrol may inhibit cancer cell development and growth.

In this two-part laboratory study, resveratrol was found to increase the production of the enzyme SIRT1, which appears to play an important role in suppressing cancer cell growth and survival.

In the first part of this study, human prostate cancer cells were exposed to resveratrol, which resulted in an increase in the production of SIRT1, and an associated decrease in tumor cell growth and survival.

In the second part of this study, a strain of mice predisposed to developing prostate cancer had their food supplemented with resveratrol.  When compared to similar mice that did not receive resveratrol supplements, exposure to dietary resveratrol resulted in a significant decrease in prostate gland size, and, more importantly, a significant reduction (54%) in precancerous changes (high-grade prostatic intraepithelial neoplasia, or HGPIN) within the prostate gland.  When the prostate glands of the resveratrol-supplemented mice were tested, increased levels of the SIRT1 enzyme were also confirmed.

This study showed that resveratrol increases SIRT1 levels, which may, in turn, reduce the development of precancerous changes that can lead to the development of prostate cancer (and, potentially, other types of cancer as well).  This study also showed that resveratrol may also be able to reduce the growth and survival of human prostate cancer cells.

There are a couple of very important caveats to mention with regards to this study.  First of all, as I have repeatedly noted before, what works on cancer cells growing in a laboratory dish, or in genetically altered laboratory animals, often fails to work on human beings.  Secondly, there is no long-term clinical data looking at the effects (either good or bad) of resveratrol supplementation in humans.  Finally, resveratrol is poorly absorbed in humans, and relatively high (and frequent) oral intake of this compound is required to achieve blood levels comparable to those concentrations used in most laboratory studies. Fortunately, at this time there are approximately a dozen human research studies underway that are assessing the impact of resveratrol supplementation on cancer risk and cancer-associated survival.  Hopefully, some of these ongoing clinical studies will shed additional important scientific light on the potential of resveratrol to prevent and treat cancer in humans, although the findings of these studies are still years away.

Links to Other Breaking Health News

Flu Cases Surge in US, Especially Among the Unvaccinated

Regular Walks Cut Stroke Risk

Falling Asleep While Driving More Common than Previously Thought

Growing Immune Cells to Fight Cancer

Celebrity Health Fads Debunked

Thousands of Surgery Mistakes Are Still Happening Each Year

New Graphic Antismoking Ads Debut in England

Kids with Food Allergies May Become Targets of Bullies

Obesity Among Young Children May Be Declining

Fresh Fruits & Vegetables May Reduce Breast Cancer Risk

Satisfaction with Life May Actually Increase with Age

Brain Changes in the Elderly May Increase Susceptibility to Being Scammed

“Talking” Therapy May Help Depression When Antidepressant Medications Fail

New Egg-Free Flu Vaccine

Graphic Cigarette Labels in Australia

Predicting Childhood Obesity at Birth

Inexpensive Power Foods

 


Dr. Wascher’s latest video:

Dark as Night, Part 1


Dark as Night, Part 1

Dark as Night, Part 1


At this time, more than 8 percent of Americans are unemployed.  According to the Bureau of Labor Statistics, however, the unemployment rate for veterans who served on active duty between September 2001 and December 2011 is now more than 12 percent.  A new website, Veterans in Healthcare, seeks to connect veterans with potential employers.  If you are a veteran who works in the healthcare field, or if you are an employer who is looking for physicians, advanced practice professionals, nurses, corpsmen/medics, or other healthcare professionals, then please take a look at Veterans in Healthcare. As a retired veteran of the U.S. Army, I would also like to personally urge you to hire a veteran whenever possible.


For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my bestselling book, “A Cancer Prevention Guide for the Human Race,” from AmazonBarnes & NobleBooks-A-MillionVroman’s Bookstore, and other fine bookstores!

Within one week of publication, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books. Within three months of publication, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list.




Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


 

Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


 

I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people from around the world who visit this premier global health information website every month.  Over the past 12 months, more than 2.3 million pages of high-quality medical research findings were served to the worldwide audience of health-conscious readers.  As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.


 


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Aspirin Dramatically Reduces Prostate Cancer Death Rate






 

A new study shows that aspirin reduces the risk of death from prostate cancer by 60 to 80%.


 

ASPIRIN DRAMATICALLY REDUCES PROSTATE CANCER DEATH RATE

 

Prostate cancer is the most common of all major cancers in men, and the second most common cause of cancer-associated death in men.  Based upon data from the American Cancer Society, 242,000 men will be diagnosed with prostate cancer in the United States in 2012, and more than 28,000 American men will die of this disease this year.

 

As I discuss in my bestselling book, A Cancer Prevention Guide for the Human Race, there are multiple evidence-based strategies available for men to decrease their risk of developing prostate cancer.  However, one area where prostate cancer prevention research in humans has been lacking is in the assessment of non-steroidal anti-inflammatory (NSAID) medications for the prevention and treatment of prostate cancer.  There is abundant scientific evidence that this class of medications (which includes aspirin, ibuprofen, naproxen, and other common anti-inflammatory drugs) can significantly reduce the risk of other types of cancer, including, notably, colon and rectal cancer.  Now, a new study involving nearly 6,000 men with prostate cancer indicates that the humble aspirin tablet appears to dramatically reduce the risk of cancer-associated death in men diagnosed with prostate cancer.

 

The prospective Cancer of the Prostate Strategic Urologic Research Endeavor (CaPSURE) Study enrolled 5,955 men with early-stage prostate cancer.  All of these men underwent either surgery (prostatectomy) or radiation therapy as primary treatment for their prostate cancer.  Among these nearly 6,000 patient volunteers, 2,175 were taking one or more blood thinning medications for other illnesses, including aspirin, Coumadin (warfarin), Plavix (clopidogrel), or Lovenox (enoxaprin).  The outcomes of these nearly 6,000 prostate cancer patients were carefully monitored over an average follow-up period of 70 months.  Importantly, throughout the course of this large prospective clinical study, patients were required to provide updated health information on a quarterly basis.  Moreover, their Urologists also separately provided ongoing clinical updates on these patients.  This unique study design, along with its prospective nature and its large cohort of patient volunteers, provides a very high level of clinical evidence for this study’s findings.

 

The results of this study were striking.  While the non-aspirin blood thinners appeared to have minimal impact on the death rate due to prostate cancer, the regular use of aspirin was associated with a whopping and highly significant 57 percent reductionin the risk of death due to prostate cancer among these nearly 6,000 patient volunteers.  Even more impressive was the finding that men with high-risk forms of prostate cancer were almost 5 times less likely to die of prostate cancer if they took aspirin (i.e., 4 percent risk of death versus 19 percent risk of death at 10 years, respectively), which equates to a nearly 80 percent reduction in the risk of dying from prostate cancer.

 

The findings of this study have significant public health implications.  For men already diagnosed with prostate cancer, and especially men who have prostate cancer with high-risk features, aspirin appears to dramatically reduce the risk of cancer-associated death for a period of at least 10 years, based upon the findings of this ongoing study.  Additionally, this finding that aspirin dramatically reduces the risk of cancer-associated death in men diagnosed with prostate cancer also strongly suggests that there may also be a role for aspirin as a prevention agent for prostate cancer, much as it is currently used to prevent colorectal cancer in high-risk patients.  I consider the findings of this clinical study to be of very high significance, and it should, in my opinion, compel a new randomized, placebo-controlled, double-blinded prospective study to validate these extremely impressive and encouraging findings.

 

Although favorable data supporting aspirin as a powerful cancer prevention agent continues to accumulate, the regular use of aspirin can be associated with serious, and even life-threatening, side effects, including ulcers of the GI tract, GI tract bleeding, kidney injury, and allergic reactions, among others.  Therefore, if you are thinking of adding aspirin to your list of medications, then I urge you to first discuss this with your doctor!

 

A Cancer Prevention Guide for the Human Race is now available in both printed and digital formats from all major bookstores.  Get your copy now, and begin living an evidence-based cancer prevention lifestyle now!

 

Please be sure to check out Dr. Wascher’s latest music video:

Dark as Night, Part 1

 


Dark as Night, Part 1

Dark as Night, Part 1


At this time, more than 8 percent of Americans are unemployed.  According to the Bureau of Labor Statistics, however, the unemployment rate for veterans who served on active duty between September 2001 and December 2011 is now more than 12 percent.  A new website, Veterans in Healthcare, seeks to connect veterans with potential employers.  If you are a veteran who works in the healthcare field, or if you are an employer who is looking for physicians, advanced practice professionals, nurses, corpsmen/medics, or other healthcare professionals, then please take a look at Veterans in Healthcare. As a retired veteran of the U.S. Army, I would also like to personally urge you to hire a veteran whenever possible.


For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my bestselling book, “A Cancer Prevention Guide for the Human Race,” from AmazonBarnes & NobleBooks-A-MillionVroman’s Bookstore, and other fine bookstores!

Within one week of publication, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books. Within three months of publication, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list.




Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


 

Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


 

I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people from around the world who visit this premier global health information website every month.  (More than 1.3 million pages of high-quality medical research findings were served to the worldwide audience of health-conscious people who visited Weekly Health Update in 2011!)  As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.


 






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Watchful Waiting (Observation) Versus Surgery for Prostate Cancer





 

A new landmark study suggests that some patients with early-stage prostate cancer can be safely observed rather than undergoing radical surgery.


 

 

WATCHFUL WAITING (OBSERVATION) VERSUS SURGERY FOR PROSTATE CANCER

In the United States, prostate cancer is the most common type of non-skin cancer occurring among men, and the second most common cause of cancer death in men.  (Lung cancer, an almost completely preventable form of cancer, sadly, remains the most common cause of cancer death for both men and women.)  The American Cancer Society estimates that, in 2012, more than 240,000 new cases of prostate cancer will be diagnosed, and more than 28,000 men will die from this form of cancer.

The debate surrounding the ideal management of early-stage prostate cancer has revolved around “watchful waiting” (observation) versus aggressive treatment with surgery or radiation therapy.  In many cases, prostate cancer is a slow-growing cancer, and when it arises in older men in particular, it seldom leads to death.  On the other hand, there are more aggressive variants of prostate cancer that spread rapidly, and these forms of prostate cancer can indeed lead to death.  The dilemma regarding which patients can be safely observed and which should be subjected to aggressive treatment has been difficult to resolve, however, because it can be difficult to determine, up front, which patients will benefit from treatment and which will not.

Last year, I reviewed a prospective randomized clinical research study from Sweden which revealed a significant improvement in survival among patients with prostate cancer who underwent prostate cancer surgery, when compared to patients who were managed with “watchful waiting”  (Prostate Cancer: Watchful Waiting Versus Surgery (Prostatectomy).)  Now, a similar new prospective randomized clinical research study provides additional important clinical information that may help doctors to identify selected prostate cancer patients who can be safely observed, thus avoiding radical cancer treatments that are associated with a high incidence of incontinence and impotence, as well as other potentially serious complications.  This new study appears in the current issue of the New England Journal of Medicine, the same journal that published last year’s Swedish prostate cancer clinical research study.

In this prospective randomized study, 731 men with newly diagnosed prostate cancer were randomly assigned to undergo radical prostate cancer surgery (prostatectomy) versus observation only.  This group of research volunteers, with an average age of 67 years, was then followed for approximately 10 years, and their outcomes were carefully monitored.  It is important to note that all of these men had early-stage prostate cancer, which appeared not to have spread outside of the prostate gland.

Following 10 years of monitoring, on average, 47 percent of the men who underwent prostatectomy died, while 50 percent of the men in the observation group died (this small difference in overall survival was not statistically significant.)  When the researchers looked at the risk of death caused specifically by prostate cancer, or due to complications associated with prostatectomy, 5.8 percent of the men in the prostatectomy group died directly as a result of either their prostate cancer or due to complications of surgery, while 8.4 percent of the men in the observation group died due to their prostate cancer, for a relative cancer-specific survival difference of 37 percent and an absolute difference of 2.6 percent in favor of the men who underwent surgery instead of observation.  Importantly, however, this observed difference in cancer-specific survival did not quite achieve statistical significance, suggesting that the cancer-specific survival benefit of radical prostatectomy in men with early-stage prostate cancer is, in general, either nonexistent or very small, at least over a 10-year period of time.

Importantly, when the authors of this study assessed prostate-specific antigen (PSA) levels, specifically, as a predictor of survival among the two groups of men who participated in this study, they found that prostatectomy did, in fact, significantly improve survival among men with a PSA level greater than 10 nanograms per milliliter (ng/ml), compared to observation alone.

As is often the case, pundits on either side of the prostate cancer treatment debate will find some ammunition in this study’s findings to support their respective positions.  Those experts who espouse aggressive treatment for most or all early-stage prostate cancers will note the nearly 3 percent improvement in absolute survival associated with radical prostatectomy, although, in this study, this difference in absolute survival was not considered to be statistically significant.  (However, it should be noted that the observed survival advantage associated with surgery in this study would have actually been higher, and perhaps statistically significant as well, had there not been a postsurgical death of one of the patients in the prostatectomy group.)  On the other hand, proponents of “watchful waiting” will point to the very small difference in observed death rates between these two groups of patients, and the relatively large number of adverse events associated with radical prostatectomy (21 percent).  However, in my view, this study’s findings offer a reasonable, evidence-based, “middle ground” strategy, based upon patients’ PSA levels.  Specifically, for older patients who have a PSA level below 10 ng/ml and no worrisome microscopic features that suggest an aggressive variant of prostate cancer, observation may indeed be a reasonable alternative to prostatectomy, based upon the findings of this landmark study.  (Unfortunately, this study did not assess radiation therapy, which is the other common form of treatment for early-stage prostate cancer.)

In completing my review of this important clinical study, I should also note that 1 out of 5 patients who enrolled in this prospective study did not remain within their assigned groups and, therefore, crossed over into the opposite group after they entered into this study.  However, while this factor does somewhat complicate the analysis of the data collected in this study, it probably does not affect the overall accuracy of the study’s conclusions.

I do not believe that this important but admittedly imperfect study will, by itself, completely resolve the ongoing debate regarding the optimal management of early-stage prostate cancer.  However, as one of only a very few well-performed randomized prospective clinical studies that have directly compared radical surgery with observation alone, and with reasonable long-term follow-up of patients, this is a very important clinical research study for both patients and their prostate cancer physicians alike.  Because of this study, both patients and their doctors will now be better able to make individualized, evidence-based decisions regarding the likely risks and benefits of surgery versus careful observation as an initial approach to prostate cancer management.


At this time, more than 8 percent of Americans are unemployed.  According to the Bureau of Labor Statistics, however, the unemployment rate for veterans who served on active duty between September 2001 and December 2011 is now more than 12 percent.  A new website, Veterans in Healthcare, seeks to connect veterans with potential employers.  If you are a veteran who works in the healthcare field, or if you are an employer who is looking for physicians, advanced practice professionals, nurses, corpsmen/medics, or other healthcare professionals, then please take a look at Veterans in Healthcare. As a retired veteran of the U.S. Army, I urge you to hire a veteran whenever possible.


For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my bestselling book, “A Cancer Prevention Guide for the Human Race,” from AmazonBarnes & NobleBooks-A-MillionVroman’s Bookstore, and other fine bookstores!

Within one week of publication, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books. Within three months of publication, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list.




Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


 

Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


 

I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people from around the world who visit this premier global health information website every month.  (More than 1.3 million pages of high-quality medical research findings were served to the worldwide audience of health-conscious people who visited Weekly Health Update in 2011!)  As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.


 






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Vigorous Exercise Activates Cancer Prevention Genes





 

New research shows that at least 3 hours per week of vigorous exercise improves the function of multiple cancer-preventing genes.


 

VIGOROUS EXERCISE ACTIVATES CANCER PREVENTION GENES

As I extensively discuss in my bestselling book, A Cancer Prevention Guide for the Human Race, moderate-to-vigorous physical exercise has been repeatedly shown to reduce our risk of developing cancer, as well as reducing the risk of recurrence of breast cancer and other types of cancer.  Moreover, there is research to suggest that this cancer-prevention benefit of exercise is independent of whether or not a person is overweight or obese.  However, the exact mechanism, or mechanisms, whereby exercise reduces cancer risk has not been clear, thus far.  Now, a newly presented research study offers some fascinating insights into potential biological links between exercise and cancer risk reduction.  This new study was just presented at the American Society of Clinical Oncology’s 2012 Genitourinary Cancers Symposium, and has been published in a supplement to the Journal of Clinical Oncology.

In this study, 70 men underwent biopsy of their prostate glands, which revealed normal prostate tissue.  These normal prostate tissue samples were then subjected to extensive genetic analysis.  These 70 men also completed detailed questionnaires regarding their exercise habits, which included questions that asked if they engaged in any vigorous physical activity at all, and whether or not they engaged in at least 3 hours of vigorous activity per week.

Genetic testing of these prostate gland biopsy specimens revealed that the function of 184 different cancer-related genes was significantly affected by vigorous exercise for at least 3 hours per week.  Among these observed changes in gene function was an increase in the function of the genes BRCA1 and BRCA2, which are known to reduce the risk of developing cancer (i.e., tumor suppressor genes).  In fact, inherited mutations of these BRCA genes are known to dramatically increase the risk of breast cancer (in both men and women), ovarian cancer, and prostate cancer in patients affected with these “deactivating” BRCA gene mutations.  Moreover, the function of genes which are involved in the normal growth and division of cells, and in the repair of damaged DNA, also improved in the men who reported at least 3 hours of vigorous physical activity per week.  Another important finding of this very impressive research study is that the men who reported engaging in vigorous physical activity forless than 3 hours per week did not show any improvement in cancer-suppressing gene function when compared to men who indicated that they did not engage in any vigorous physical activity.

The findings of this innovative research study are hugely important, in my view, as it is one of the first studies to identify specific genetic mechanisms that may potentially explain why vigorous exercise reduces cancer risk.  While many other clinical studies have indirectly linked increased levels of physical activity to a reduced risk of developing cancer, this intriguing research study has identified multiple actual cancer-suppressing genes whose function appears to be significantly improved, or “upregulated,” in response to vigorous, frequent exercise.  The finding that at least 3 hours of vigorous activity per week is necessary to improve the function of these critical anti-cancer genes is particularly important, and may serve as a guide as to how much exercise we need to engage in to significantly lower our risk of developing cancer.  Additionally, knowing which cancer-suppressing genes respond favorably to frequent and vigorous exercise may also help scientists to develop new strategies to manipulate these anti-cancer genes, in an effort to further reduce our risk of developing cancer.

This study is a crucial advance in our understanding of the biological mechanisms whereby higher levels of physical activity appear to reduce the risk of developing cancer.  Although this is a rather small study, its implications with respect to cancer prevention are likely to be huge!


For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my bestselling book, “A Cancer Prevention Guide for the Human Race,” from AmazonBarnes & NobleBooks-A-MillionVroman’s Bookstore, and other fine bookstores!

Within one week of publication, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books. Within three months of publication, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list.



Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people from around the world who visit this premier global health information website every month.  (More than 1.3 million pages of high-quality medical research findings were served to the worldwide audience of health-conscious people who visited Weekly Health Update in 2011!)  As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.


 




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Sweet Potato Greens and Prostate Cancer

Welcome to Weekly Health Update



New research suggests that sweet potato greens may have a role in prostate cancer prevention and treatment.



SWEET POTATO GREENS AND PROSTATE CANCER

As I discuss in my bestselling evidence-based book, A Cancer Prevention Guide for the Human Race, even conservative clinical research assessments strongly suggest that at least 50 percent of all new cancer cases are linked to modifiable lifestyle and dietary habits.  Polyphenols, a group of powerful dietary antioxidant compounds that I extensively discuss in A Cancer Prevention Guide for the Human Race, have been extensively studied in numerous laboratory and clinical research studies as potential cancer prevention nutrients.  Now, a newly published study suggests that polyphenol-rich sweet potato greens may have significant anticancer activity against prostate cancer

In this new study, which appears in the current issue of the journal Carcinogenesis, an extract of sweet potato greens was first tested in the laboratory with human prostate cancer cells growing in culture.  Molecular studies were then performed, which revealed that sweet potato greens extract shut down important cell growth biochemical pathways in human prostate cancer cells, and accelerated cancer cell death through a mechanism known as apoptosis.  (Interestingly, and importantly, however, sweet potato greens extract appeared to have no adverse effects on normal human prostate gland cells.)

As it is well known that the results of laboratory-based studies often cannot be reproduced in animal or human studies, the authors of this study then implanted human prostate cancer cells into laboratory mice.  These same mice were then fed sweet potato greens extract (400 milligrams per kilogram per day), while another group of mice (the “control group”) did not receive any sweet potato greens extract.  At the end of the study, the scientists conducting this research discovered that the prostate cancer tumors growing in the mice who received the sweet potato greens extract were, on average, almost 70 percent smaller than the tumors growing in the control group mice!  (Once again, there also appeared to be no adverse effects on normal tissues and organs in the mice that received the sweet potato greens extract.)

This research study is the first study to identify significant anticancer effects against prostate cancer associated with sweet potato greens in both cancer cell cultures and in mammals.  The potent anticancer effects of sweet potato greens extract, as demonstrated in this very elegant study, and combined with the apparent lack of toxicity, suggest that this polyphenol-rich vegetable may have a role in prostate cancer prevention and, perhaps, prostate cancer treatment; although it will be necessary to repeat this laboratory study in humans to determine if sweet potato greens have similar anticancer effects in people.

For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, “A Cancer Prevention Guide for the Human Race,” from AmazonBarnes & NobleBooks-A-Million,Vroman’s Bookstore, and other fine bookstores!


On Thanksgiving Day, 2010, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books! On Christmas Day, 2010, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list!


Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


For a different perspective on Dr. Wascher, please click on the following YouTube link:

Texas Blues Jam


I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month. (More than 1.2 million health-conscious people visited Weekly Health Update in 2010!) As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.


 


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Ginger May Prevent Prostate Cancer

Welcome to Weekly Health Update


New research suggests that ginger root extract may have potent activity against prostate cancer and other types of cancer.



 

GINGER MAY PREVENT PROSTATE CANCER

As I discuss in my book, A Cancer Prevention Guide for the Human Race, there is a growing body of research evidence demonstrating potent cancer properties associated with certain foods and nutrients. While much of the available research in support of specific dietary and other lifestyle-related approaches to cancer prevention is of low scientific quality, more recent cancer prevention research studies have provided higher levels of scientific and clinical evidence in support of an evidence-based approach to a cancer prevention lifestyle.

A newly published research study, which appears in the current issue of the British Journal of Nutrition, suggests that ginger root may possess clinically important cancer prevention activity. (Previous research studies have also shown that ginger extracts are capable of reducing cancer cell growth in laboratory settings, and are associated with antioxidant and anti-inflammatory effects as well.)

In this particular research study, human prostate cancer cells were transplanted into laboratory mice. In the group of mice that received daily ginger extract dietary supplements (100 milligrams of ginger extract per kilogram of body weight), the growth of these transplanted prostate cancer tumors was reduced by a rather impressive 56 percent when compared to the mice that did not receive ginger extract. When the transplanted prostate cancer tumors were removed from the mice and further studied, the researchers found that the tumors in the mice that had received ginger extract displayed extensive cancer cell death (as compared to the tumors taken from the mice that did not receive ginger extract). Importantly, there was no evidence of side effects noted among the mice that received the ginger extract supplements in this study.

The findings of this laboratory research study, when combined with the findings of previous research studies, suggest that ginger may have significant anti-cancer properties. These high-quality laboratory studies have identified multiple biochemical mechanisms whereby ginger appears to significantly impair cancer cell growth and reproduction, and increase cancer cell death through a biological process known as apoptosis.

While the findings of this laboratory research study are highly intriguing, I must caution readers that what works in laboratory mice with a genetically engineered faulty immune system does not always turn out to work in humans. Therefore, a prospective, randomized, placebo-controlled clinical research trial will be necessary to determine whether or not ginger supplements can actually reduce prostate cancer risk (and the risk of other cancers) in humans, or slow down the progression of cancer in patients who have already been diagnosed with prostate cancer or other cancers. At the same time, ginger has been used for thousands of years, and most research studies indicate no apparent toxicity in humans after consuming doses of ginger far greater than the dose that was utilized in this particular laboratory study. (As always, however, I strongly recommend that readers first check with their personal physician before adding any new supplements to their diet.)


 

For a comprehensive guide to living an evidence-based cancer prevention lifestyle, order your copy of my new book, A Cancer Prevention Guide for the Human Race.  For the price of a cheeseburger, fries, and a shake, you can purchase this landmark new book, in both paperback and e-book formats, and begin living an evidence-based cancer prevention lifestyle today!

For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, A Cancer Prevention Guide for the Human Race,” from Amazon, Barnes & Noble, Books-A-Million,Vroman’s Bookstore, and other fine bookstores!

On Thanksgiving Day, 2010, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books! On Christmas Day, 2010, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list!


Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity



Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author



For a different perspective on Dr. Wascher, please click on the following YouTube link:

Texas Blues Jam



I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month. (More than 1.2 million health-conscious people visited Weekly Health Update in 2010!) As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.





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Acetaminophen (Tylenol) May Prevent Prostate Cancer

Welcome to Weekly Health Update


“A critical weekly review of important new research findings for health-conscious readers”



ACETAMINOPHEN (TYLENOL) MAY PREVENT PROSTATE CANCER

As I note in my recent book, A Cancer Prevention Guide for the Human Race, chronic inflammation is thought to play an important role in the development of many types of cancer. For this reason, non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin, ibuprofen, naproxen, and celecoxib, have been intensively studied as potential cancer prevention medications. Unfortunately, the enthusiasm for these medications, at least when it comes to prescribing them for patients who are at only average risk of developing cancer, has cooled considerably, as multiple research studies have linked the chronic use of most NSAIDs (other than aspirin) with an unacceptably high risk of cardiovascular disease.

Acetaminophen, which includes Tylenol, has been used for decades to treat both pain and fever. While we still don’t understand exactly how acetaminophen relieves pain or fever, it appears that mechanisms other than direct anti-inflammatory activity are involved (unlike the pure anti-inflammatory actions of NSAIDs). However, acetaminophen is still thought to possess at least mild anti-inflammatory activity, and so some researchers have recommended that this very commonly used over-the-counter medication be studied as a possible cancer prevention drug.

Now, a newly published prospective clinical research study, from the American Cancer Society, suggests that acetaminophen may indeed be able to reduce the risk of cancer, and prostate cancer in particular. In this huge study (the Cancer Prevention Study II Nutrition Cohort Study), which appears in the current issue of the journal Cancer Epidemiology, Biomarkers & Prevention, 78,485 men were followed for an average of 15 years. Throughout this prospective public health study, this enormous group of male volunteers completed detailed questionnaires regarding their dietary and medication habits. The resulting data that was collected was then analyzed, taking into account other potentially “confounding” prostate cancer risk factors such as age, race, weight, the presence or absence of diabetes, history of NSAID use, and history of prostate-specific antigen (PSA) testing.

The findings of this study were quite dramatic. Among the men who regularly took 30 or more acetaminophen pills per month, for 5 or more years, the incidence of prostate cancer was decreased by 38 percent when compared with the men who regularly took acetaminophen for less than 5 years during the course of this clinical research study. Moreover, the incidence of aggressive forms of prostate cancer was reduced by a whopping 51 percent among the men who regularly took acetaminophen for at least 5 years!

The findings of this very large public health study are extremely intriguing, although they will have to be validated by a prospective, randomized, placebo-controlled clinical research trial before acetaminophen can be formally recommended as a cancer prevention medication. (I should also point out that the excessive use of acetaminophen can be associated with significant side effects, including severe and permanent liver damage.) Should these findings be validated in the future, then acetaminophen could become a powerful addition to a cancer prevention lifestyle.


For a comprehensive guide to living an evidence-based cancer prevention lifestyle, order your copy of my new book, A Cancer Prevention Guide for the Human Race.  For the price of a cheeseburger, fries, and a shake, you can purchase this landmark new book, in both paperback and e-book formats, and begin living an evidence-based cancer prevention lifestyle today!

For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, A Cancer Prevention Guide for the Human Race,” from Amazon, Barnes & Noble, Books-A-Million,Vroman’s Bookstore, and other fine bookstores!

On Thanksgiving Day, 2010, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books! On Christmas Day, 2010, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list!


Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


For a different perspective on Dr. Wascher, please click on the following YouTube link:

Texas Blues Jam


I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month. (More than 1.2 million health-conscious people visited Weekly Health Update in 2010!) As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.




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Statin Drugs Decrease Prostate Cancer Risk

Welcome to Weekly Health Update


“A critical weekly review of important new research findings for health-conscious readers”



 

STATIN DRUGS DECREASE PROSTATE CANCER RISK

As I discuss in my book, A Cancer Prevention Guide for the Human Race, the role of cholesterol-lowering statin drugs in cancer prevention continues to be debated because of contradictory research findings. (While some clinical research studies have suggested that long-term statin use may reduce cancer risk, other studies have not shown any apparent improvement in cancer risk associated with these commonly prescribed medications.) However, a newly published public health study from the Veterans Affairs New England Healthcare System, which appears in the current issue of the Journal of the National Cancer Institute, suggests that statin drugs may be associated with a significant decrease in the risk of prostate cancer.

In this very large study, the medical records of 55,875 veterans were evaluated. Among this large group of veterans, 41,078 were taking statin drugs, while the remaining 14,797 men were taking medication for high blood pressure (but not statin drugs.) When the incidence of prostate cancer was assessed in each of these two groups of men, the researchers performing this research study found that there was a 31 percent decrease in the incidence of prostate cancer among the group of male veterans that took statin drugs. Moreover, the incidence of high-risk (high grade) prostate cancer among the men taking statins was a whopping 60 percent lower than that observed among the veterans who were not taking statin drugs.

Although the precise mechanism(s) of action is not entirely clear, long-term statin use in this large group of older male veterans appeared to significantly reduce the overall risk of prostate cancer, as well as the risk of more aggressive types of prostate cancer. (Like other research studies, this study also found a trend towards increased prostate cancer risk in men with elevated levels of cholesterol in their blood, and so decreased cholesterol levels, due to statin drugs, may explain, at least in part, the decrease in prostate cancer risk observed in the veterans who took statins in this research study. However, statin drugs also reduce inflammation in the body, and chronic inflammation of the prostate gland is also thought to be a risk factor for this common form of cancer.)

As with all clinical research studies that are based upon the review of patient medical records, the results of this research study need to be confirmed with a prospective, randomized, blinded, placebo-controlled clinical research trial. Until this “gold standard” method of clinical research is performed, however, this large retrospective study of U.S. veterans offers some of the strongest research evidence linking long-term statin drug use with a decreased risk of prostate cancer.



For a comprehensive guide to living an evidence-based cancer prevention lifestyle, order your copy of my new book, A Cancer Prevention Guide for the Human Race.  For the price of a cheeseburger, fries, and a shake, you can purchase this landmark new book, in both paperback and e-book formats, and begin living an evidence-based cancer prevention lifestyle today!

For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, A Cancer Prevention Guide for the Human Race,” from Amazon, Barnes & Noble, Books-A-Million,Vroman’s Bookstore, and other fine bookstores!

On Thanksgiving Day, 2010, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books! On Christmas Day, 2010, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list!


Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


For a different perspective on Dr. Wascher, please click on the following YouTube link:

Texas Blues Jam


I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month. (More than 1.2 million health-conscious people visited Weekly Health Update in 2010!) As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.





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