Obesity Linked to Deadly Form of Esophagus and Upper Stomach Cancer



 

A large new study reveals that obesity around the stomach area sharply increases the risk of cancer of the esophagus and upper stomach.


 

OBESITY LINKED TO DEADLY FORM OF ESOPHAGUS AND UPPER STOMACH CANCER

As I discuss in my bestselling book, A Cancer Prevention Guide for the Human Race, obesity remains an underappreciated risk factor for cancer, including some of the most deadly forms of cancer.  As I also specifically discuss in my book, the rising incidence of a formerly rare form of cancer, adenocarcinoma of the esophagus and the gastroesophageal junction (the area where the esophagus and stomach join together), has been directly linked to steadily increasing levels of obesity in the United States and around the world by previous studies.  Now, newly reported data from a huge prospective public health study, the National Institutes of Health-American Association of Retired Persons (NIH-AARP) study, provides further insight into the serious impact of obesity on the risk of these formerly rare types of cancer.  This update of the NIH-AARP study appears in the current issue of the journal Gut.

The massive NIH-AARP study currently includes a whopping 218,854 volunteers, making it one of the largest ongoing prospective public health studies in the world.  Because of the enormous size of this clinical study, its findings are very likely to be highly significant.

During the course of this public health study so far, 253 cases of esophageal adenocarcinoma and 191 cases of upper stomach (gastroesophageal junction) adenocarcinoma have been diagnosed among the study’s volunteers.  After analyzing the known risk factors (including obesity) for esophageal and gastroesophageal junction adenocarcinoma in this huge group of research study volunteers, obesity, by itself, was found to double the risk of developing this deadly form of cancer.  Similarly, obesity, alone, nearly quadrupled the risk of gastroesophageal junction adenocarcinoma.  Moreover, among study volunteers with normal body weight, but with increased fat in the abdominal area, esophageal adenocarcinoma was nearly two times more likely when compared to normal-weight adults without abdominal obesity.

The findings of this new study reinforce the conclusions of similar, earlier studies that I discuss in A Cancer Prevention Guide for the Human Race, and confirm that obesity, and especially obesity in the abdominal area, significantly increases the risk of these two formerly uncommon (and highly lethal) types of cancer.

At the present time, nearly two-thirds of the U.S. population is overweight or obese, and this still growing epidemic of increasing body weight shows no signs of slowing down.  As I discuss in my bestselling book, even conservative evidence-based estimates suggest that at least 15 percent of all cancer cases are directly linked to obesity, including several of the most dangerous forms of cancer.  If the incidence of obesity does indeed continue to rise from its already very high current level, obesity could, in time, overtake all other known modifiable risk factors for cancer.

If you are overweight or obese, please see your doctor about starting a sensible weight loss program, including healthy dieting and physical exercise.

 

For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my bestselling book, “A Cancer Prevention Guide for the Human Race,” from AmazonBarnes & NobleBooks-A-MillionVroman’s Bookstore, and other fine bookstores!

Within one week of publication, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books. Within three months of publication, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list.




Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


 

Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


 

I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people from around the world who visit this premier global health information website every month.  (More than 1.3 million pages of high-quality medical research findings were served to the worldwide audience of health-conscious people who visited Weekly Health Update in 2011!)  As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.


 





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Aspirin Cuts Cancer Risk and Cancer Death Rates





A new study shows that aspirin not only reduces the risk of getting cancer, but may also reduce death rates in patients with cancer.


 

ASPIRIN CUTS CANCER RISK AND CANCER DEATH RATES

As I discuss in my bestselling book, A Cancer Prevention Guide for the Human Race, aspirin may be able to do much more than just relieve a headache, or reduce the risk of heart disease.  Indeed, a growing body of scientific evidence strongly suggests that aspirin may also significantly reduce the risk of developing cancer.  Now, a newly published research study, which appears in the current issue of the Lancet Oncology journal, suggests that aspirin may not only reduce the risk of developing certain cancers, but may also reduce the risk of cancer spread in patients who have already been diagnosed with cancer, as well.

An important and unique aspect of this particular study is that it reviewed the results from numerous previous aspirin studies, including both highly powered prospective randomized clinical research studies and lower powered public health studies.

Based upon this massive review study, the regular use of aspirin was associated with a 38 percent reduction in the risk of developing colorectal cancer, and a 42 percent reduction in the risk of death due to colorectal cancer.  Similar reductions in the risk of other major cancer killers were also observed with regular aspirin use, including cancers of the esophagus, stomach, bile ducts, liver and breast.

Among patients already diagnosed with cancer, regular aspirin use was associated with a 31 percent decrease in the incidence of distant spread of cancer.  (This is an important finding, as most patients who die from cancer do so due to the distant spread, or metastasis, of their cancer rather than due to the presence of their original, or primary, tumor alone.)

The findings of this important study are highly significant, as they lend further important evidence that the humble aspirin tablet can significantly reduce our risk of developing many of the most prolific cancer killers of mankind.  Moreover, regular aspirin use may also reduce the risk of distant spread (metastasis) for many types of cancer, which may, in turn, reduce the risk of death associated with these cancers.

As aspirin use can be associated with serious side effects, including GI tract ulcers, bleeding, kidney injury, and other potentially serious health complications, I recommend that patients first talk with their doctor before starting daily aspirin therapy.


For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my bestselling book, “A Cancer Prevention Guide for the Human Race,” from AmazonBarnes & NobleBooks-A-MillionVroman’s Bookstore, and other fine bookstores!

Within one week of publication, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books. Within three months of publication, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.comTop 100 New Book Releases in Cancer” list.


Disclaimer:  As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author


For a lighthearted perspective on Dr. Wascher, please click on the following YouTube link:

Texas Blues Jam


I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people from around the world who visit this premier global health information website every month.  (More than 1.3 million pages of high-quality medical research findings were served to the worldwide audience of health-conscious people who visited Weekly Health Update in 2011!)  As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.


 



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Dietary Salt (Sodium) Increases Stomach Cancer Risk

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Welcome to Weekly Health Update


“A critical weekly review of important new research findings for health-conscious readers”


DIETARY SALT (SODIUM) INCREASES STOMACH CANCER RISK

 

Cancer of the stomach occurs only about half as commonly today in the United States as it did 30 years ago, but it remains one of the “bad actor” cancers that are associated with a high likelihood of death.  On a global scale, stomach cancer remains the #2 cause of cancer-associated death, while in the United States, gastric cancer is currently the #7 cause of cancer-associated death.

Known risk factors for stomach cancer include chronic infection with the Helicobacter pylori bacterium (and other causes of chronic gastric inflammation), smoking, obesity, decreased acid secretion within the stomach, stomach ulcers, pernicious anemia, a family history of stomach cancer, certain inherited cancer syndromes, and other less common risk factors.  As with other GI tract cancers, diet also appears to play an important role in gastric cancer risk.  For example, gastric cancer is more common among people who eat a lot of processed meat and red meat, smoked foods, and salt-cured or pickled foods.  On the other hand, stomach cancer is less common among people who consume a large amount of fresh fruits and vegetables.

The role of salt in gastric cancer risk has been a subject of some debate, as clinical research studies have come to varying and contradictory conclusions regarding this issue.  However, a newly published public health study, which appears in the current issue of the British Journal of Cancer, appears to strongly link excess salt consumption with an increased risk of developing stomach cancer.  In this case-control study, 442 patients with stomach cancer, and 649 healthy patients without any clinical evidence of cancer, were evaluated.  Multiple previously validated dietary questionnaires were administered to all of the study volunteers, with particular attention to dietary salt intake. 

The results of this public health study indicated that the risk of stomach cancer was twice as common among patients who regularly consumed the highest amounts of salt, when compared to patients with the smallest amount of regular salt intake.  After adjusting for other risk factors known to be associated with gastric cancer risk (including Helicobacter pylori status, smoking history, and other known gastric cancer risk factors), increased salt intake was still associated with a doubling of gastric cancer risk. 

While case-control studies, such as this one, do not offer high-level clinical research evidence (unlike the “gold standard” prospective, randomized, blinded clinical research trials that provide “Level 1” clinical research data), the findings of this observational study nonetheless add to an increasing volume of data linking increased salt intake with gastric cancer risk.

Excessive salt intake has also been clearly linked to a significant increase in the risk of high blood pressure, stroke, and cardiovascular disease.  Most hypertension experts are currently recommending that we lower our average daily intake of sodium, from the current 3,500 to 4,000 milligram (mg) per day level in the United States, to somewhere around 1,500 mg per day.  At this level of sodium intake reduction, significant improvements in high blood pressure, and in the risk of stroke and cardiovascular disease, have been demonstrated by multiple high-quality clinical research studies.  (An excellent pamphlet on the topic of dietary sodium reduction, as part of a heart-healthy diet, has been published online by the National Institutes of Health.)    

As with many other dietary and lifestyle factors that have been shown to reduce cancer risk, reducing sodium intake, by reducing your dietary salt consumption, can pay big health dividends not only in terms of cancer risk reduction, but also in terms of reducing those other great global killers of mankind, cardiovascular disease and stroke!

 

 

For a complete discussion of the role of diet in cancer prevention, and other important evidence-based approaches to cancer prevention, order your copy of my new book, A Cancer Prevention Guide for the Human Race, now!  For the price of a cheeseburger, fries, and a shake, you can purchase this landmark new book, in both paperback and e-book formats, and begin living an evidence-based cancer prevention lifestyle today!

 

For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, A Cancer Prevention Guide for the Human Race,” from Amazon, Barnes & Noble, Books-A-Million, Vroman’s Bookstore, and other fine bookstores!   

 

On Thanksgiving Day, 2010, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com “Top 100 Bestseller’s List” for Kindle e-books!  On Christmas Day, 2010, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.com Top 100 New Book Releases in Cancer” list! 



Disclaimer: As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity




Dr. Wascher is an oncologic surgeon, a professor of surgery, a cancer researcher, an oncology consultant, and a widely published author




For a different perspective on Dr. Wascher, please click on the following YouTube link: 

Texas Blues Jam



I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month.  (More than 1.2 million health-conscious people visited Weekly Health Update in 2010!)  As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.





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Soy Foods & Stomach Cancer Risk

May 9, 2010 by  
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Welcome to Weekly Health Update



“A critical weekly review of important new research findings for health-conscious readers” 

SOY FOODS & STOMACH CANCER RISK

There is a great deal of interest regarding the potential effects of soy-based foods (like tofu and soy beverages) on cancer risk.  As discussed in my forthcoming book (“A Cancer Prevention Guide for the Human Race”), there is a growing body of laboratory and human research data suggesting that dietary soy isoflavones might be able to reduce the risk of prostate and breast cancer.

Now, a newly published clinical research study from Korea suggests that high levels of soy isoflavones in the blood may also be linked to a reduced risk of stomach cancer, as well.  (Korea has one of the highest incidences of stomach cancer in the world.)  This study appears in the current issue of the journal Cancer Epidemiology, Biomarkers & Prevention.

As most of the published research in the area of cancer prevention is based upon the subjective recall of patient volunteers regarding their diet (and other habits), the authors of this study chose, instead, to directly measure the levels of soy isoflavones in the blood of patient volunteers.  This study included 131 patients with recently diagnosed stomach cancer, and 393 “control” patients who did not have stomach (gastric) cancer.  Blood levels of the two major dietary soy isoflavones (genistein and daidzein) were directly measured in all 524 of these research volunteers, and these results were compared between the patients with stomach cancer and the “control” patients without gastric cancer.

Study volunteers with the highest levels of genistein in their blood, when compared with those with the lowest levels, were found to be 46 percent less likely to be diagnosed with stomach cancer.  Even more impressive was the finding that study volunteers with the highest daidzein blood levels were 79 percent less likely to be diagnosed with stomach cancer when compared to the volunteers with the lowest levels of daidzen in their blood

While there may be other health-related factors at work among the study volunteers with high levels of soy isoflavones in their blood that could explain the much lower stomach cancer risk observed in these same patients, this study’s results are nonetheless intriguing enough to justify a large scale, prospective, randomized, placebo-controlled soy isoflavone clinical research study to confirm the findings of this relatively small Korean public health study.

 

To learn more about the role of soy isoflavones as potential cancer prevention nutrients, look for the publication of my new landmark evidence-based book, “A Cancer Prevention Guide for the Human Race,” in the summer of this year.





Disclaimer: As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity


Dr. Wascher is an oncologic surgeon, a professor of surgery, a cancer researcher, an oncology consultant, and a widely published author



For a different perspective on Dr. Wascher, please click on the following YouTube link: 

http://www.youtube.com/watch?v=7-Tdv7XW0qg



I and the staff of Weekly Health Update would like to take this opportunity to thank the nearly 120,000 new and returning readers who visited our premier global health information website last month.  As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can. 


 

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