Walnuts, Cholesterol, LDL & Triglycerides

March 7, 2010 by  
Filed under Uncategorized


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  “A critical weekly review of important new research findings for health-conscious readers” 


Walnuts are rich in anti-inflammatory nutrients, including omega-3 fatty acids and ellagic acid.   Previous research has shown that the regular consumption of walnuts appears to improve cardiovascular function following high-fat meals.  In diabetics, who face an increased risk of cardiovascular disease, walnuts also appear to improve cardiovascular function.

A newly published prospective, randomized clinical research trial, which appears in the European Journal of Clinical Nutrition, evaluated the effects of a walnut-supplemented diet on 87 adults with normal-to-high cholesterol levels in their blood.  This study used a “crossover” approach, in which all of the patient volunteers received walnut supplements for 6 months, and were then switched to a walnut-free diet for another 6 months.  During this 12-month study, blood tests were performed at the beginning of the study, and then at 4, 6, 10 and 12 months into the study.  Because of the crossover design of this study, the researchers were able to directly compare the effects of walnut supplementation on body weight, total cholesterol, LDL cholesterol (the “bad cholesterol”), HDL cholesterol (the “good cholesterol”), and fatty acids (triglycerides).  (Together, these compounds are referred to as “lipids.”)

As has been observed in previous clinical studies of shorter duration, this study found that a 6-month period of walnut supplementation resulted in significant reductions in total cholesterol and triglyceride levels.  LDL levels were also reduced, although this finding just barely failed to reach statistical significance.  Importantly, these favorable changes in blood lipid levels were found to be more pronounced in patients with elevated total cholesterol and LDL cholesterol levels.  (I should note that significant reductions in LDL blood levels have been observed in response to adding walnuts to the diet of patients with elevated LDL levels, in other studies.)

While statins, and other lipid-lowering drugs, have revolutionized the management of elevated cholesterol and triglycerides, and have been shown to significantly reduce the risk of cardiovascular disease (and death due to cardiovascular disease), not all patients with hyperlipidemia can tolerate these drugs.  Moreover, as with all medications, these lipid-lowering drugs are not equally effective in all patients, and many patients with hyperlipidemia will continue to have elevated LDL cholesterol and/or triglyceride levels despite taking lipid-lowering drugs.

Studies such as this one suggest that the addition of walnuts to one’s diet may be a useful adjunct in lowering elevated LDL cholesterol and triglyceride levels.  (As always, I encourage everyone to check with their doctor before making any significant alterations in their diet, especially if you have one or more chronic illnesses.)

For a detailed and comprehensive evaluation of the role of nuts, omega-3 fatty acids, ellagic acid, and other dietary modifications, as part of a cancer prevention lifestyle, look for the publication of my new book, “A Cancer Prevention Guide for the Human Race,” in the spring of this year.

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Disclaimer: As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity

Dr. Wascher is an oncologic surgeon, a professor of surgery, a cancer researcher, an oncology consultant, and a widely published author

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5 Comments on "Walnuts, Cholesterol, LDL & Triglycerides"

  1. Kirsten Walstedt on Sun, 17th Oct 2010 6:33 pm 

    I am greatly enjoying your columns since I stumbled upon them recently while looking for which types of foods will boost HDL and lower LDL and triglycerides. Although I just tested under 200 for total cholesterol and with normal HDL and LDL, my HDL is not as high as I want it to be and my triglycerides are somewhat elevated. One month ago I started eating a much healthier diet after years of bad habits and exercising again. The blood tests were before I made the changes, so I was quite relieved to find out that my cholesterol was not worse than it is. This however has not made me relax my new habits, but instead has inspired me to lower my cholesterol even more.

    Some of the things I was excited to hear were good for cholesterol were avocadoes, olives, salmon and almonds as I love all of these.

    I have read your columns on walnuts and since I really do not like the taste of them but I love almonds I am wondering if almonds are as good for cholesterol as walnuts are? Is there a scale of how much good each nut you named can do, with walnuts at the top and then the other nuts and finally peanuts? I love almonds, peanuts, pistachios and macadamia nuts but do not like walnuts or pecans. Please let me know. Thank you and look forward to reading more columns!

  2. admin on Tue, 19th Oct 2010 7:29 pm 

    There is some research evidence to suggest that the moderate intake of pistachios may improve elevated LDL levels, while the data for almonds is more mixed (with some studies showing improvements in blood lipid profiles, while other studies have not shown improvements in elevated LDL levels or decreased HDL levels). At the same time, most “tree nuts” are rich in monounsaturated and polyunsaturated fats, which are thought by some experts to decrease elevated LDL levels (or, at least, they do not appear to raise LDL levels).

    Thank you for writing.


    Robert A. Wascher, MD, FACS

    Author, “A Cancer Prevention Guide for the Human Race” (2010)

  3. BHarris on Mon, 20th Dec 2010 7:17 am 

    Unfortunately, walnuts interfere with the thyroid medication I’m on.

  4. admin on Fri, 24th Dec 2010 2:43 pm 

    Fortunately, there are many other approaches to reducing LDL levels!

    Sincerely/ Robert A. Wascher, MD, FACS

  5. Loretta on Sun, 15th Jan 2012 3:43 am 

    Love the blog!

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